The Intern At Work: Internal Medicine cover image

The Intern At Work: Internal Medicine

169. The Internist's Guide to Heart Failure with Reduced Ejection Fraction (Repeat)

Oct 30, 2022
29:48

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Quick takeaways

  • 2021 guidelines recommend quadruple therapy for heart failure with reduced ejection fraction, integrating ARNIs, beta blockers, mineralocorticoid antagonists, and SGLT2 inhibitors.
  • Early initiation of guideline-directed medical therapies in a hospital setting with gradual titration for optimal patient outcomes.

Deep dives

The Evolution of Heart Failure Therapy

The 2021 updates to the CCS and CHFS Heart Failure Guidelines have shifted from triple therapy to quadruple therapy for heart failure patients with reduced ejection fraction, integrating ARNIs, beta blockers, mineralocorticoid antagonists, and SGLT2 inhibitors as the foundation of medical management.

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