Boundless Life This FASCINATING Molecule Originally Boosted Muscle & Endurance But Is *Now* Being Shown To Reverse Immune Aging?! Urolithin A With Dr. Anurag Singh
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Sep 4, 2025 
Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition, shares his expertise on Urolithin A, a postbiotic beneficial for muscle strength and immune health. He discusses its role in mitochondrial function and potential to reverse immune aging, linking diet quality to its efficacy. The conversation covers dietary sources, optimal dosages, and various delivery methods. Singh highlights recent research on how Urolithin A can rejuvenate immune functions and enhance health span, making complex topics accessible and engaging.
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Mitophagy Powers Muscle Performance
- Urolithin A activates mitophagy, recycling damaged mitochondria into healthier ones to increase cellular energy.
- Clinical trials show 2–4 months of supplementation improves leg strength, peak VO2, and exercise recovery in older adults.
Take The Clinically Tested Dose
- Use 500 mg–1 g daily to activate mitophagy; 500 mg starts benefits while 1 g amplifies effects.
- Expect stronger endurance and greater systemic impact at the 1 g dose.
Dietary Levels Vary Widely
- Dietary production of urolithin A depends on gut microbiome and intake of precursors from pomegranates, berries, and nuts.
- Only ~10% of U.S. adults have circulating urolithin A from diet, so supplementation is often necessary.
