Leslie Kenny, a patient advocate who reversed lupus and rheumatoid arthritis through lifestyle changes, dives into the transformative power of spermidine. She shares how this remarkable molecule can enhance hair growth, improve sleep, and boost immune function while reducing signs of aging. Discover the difference between food-derived and synthetic spermidine and why it’s vital for health. Leslie also reveals how spermidine activates autophagy and preserves muscle mass, offering a promising path to longevity that traditional medicine overlooks.
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From Terminal Prognosis To Recovery
Leslie Kenny was told at 39 she'd likely die in five years from lupus and rheumatoid arthritis and was advised to stop IVF.
She pursued IVIG and lifestyle changes and eventually normalized tests and symptoms without long-term immunosuppressants.
insights INSIGHT
Spermidine Declines With Age And Antibiotics
Spermidine activates autophagy and mitophagy and is produced by our gut microbiome and tissues.
Production declines with age and after antibiotic exposure, increasing reliance on dietary sources.
insights INSIGHT
Autophagy Without Muscle Loss
Spermidine activates autophagy via TFEB/hypusination rather than mTOR inhibition.
This alternative route renews cells without causing muscle loss like mTOR inhibitors can.
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What if one natural molecule could reverse key signs of aging, repair your immune system, grow your hair, and even help you sleep better?
In this episode, Robert Lufkin, MD, sits down with Leslie Kenny, a patient advocate with a remarkable story. At 39, she was told she had only 5 years to live with lupus and rheumatoid arthritis. Instead, through lifestyle changes and a breakthrough discovery about spermidine, she now enjoys extraordinary health — with a biological age of just 21 at age 60.
👉 You’ll learn:
What spermidine is and why it’s overlooked in longevity research
How it activates autophagy, mitophagy, and immune rejuvenation without muscle loss
The difference between food-derived vs. synthetic spermidine (and why it matters)
Health Longevity Secrets