
Health Longevity Secrets
A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including longevity, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, consciousness, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe and get ready to change your life. HLS is hosted by Robert Lufkin MD, a physician/medical school professor and New York Times Bestselling auhtor focusing on the applied science of health and longevity through lifestyle and other tools in order to cultivate consciousness, and live life to the fullest .'Envision a world of love, abundance, and generosity'.
Latest episodes

Apr 22, 2025 • 39min
Why Calories Don't Count with Dr Giles Yeo
Dr. Giles Yeo, Cambridge University Professor, author of "Why Calories Don't Count," and Chief Science Advisor at Rio demolishes weight management myths with scientific precision and personal warmth. This mind-shifting conversation reveals why blaming people for obesity fundamentally misunderstands human biology. Full disclosure: I am also an advisor for Rio but I only work with companies I believe in and would use for myself and my family.Bold scientific insights abound as Dr. Yeo reveals why simple calorie counting fails. Rather than fixating on calories, he advocates understanding how different foods affect our bodies uniquely, making a compelling case for cooking at home with quality ingredients as his personal health strategy.The discussion ventures into today's most transformative weight management tools, with Dr. Yeo describing GLP-1 medications as the most effective treatment options he's encountered in 30 years of obesity research. These medications signal fullness to the brain, but surprisingly affect other reward-seeking behaviors too - from alcohol consumption to addictive tendencies. The conversation explores fascinating frontiers in brain science, including Dr. Yeo's groundbreaking work mapping human hypothalamus feeding circuits, and examines how AI-assisted health applications might revolutionize personalized nutrition. Throughout, his compassionate message resonates: obesity isn't a character flaw - it's the result of biological and environmental factors that require understanding, not judgment. Discover why this disco-dancing geneticist believes personalized approaches, not quick fixes, are the future of health optimization.https://rio.life/Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Apr 15, 2025 • 41min
The Future of Aging with Aubrey de Grey
Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that's gaining mainstream scientific acceptance after initial skepticism.The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider's assessment of major players including HEvolution (Saudi-backed), Altos Labs (Bezos-funded), Calico (Google-funded) and Retro Biosciences (Sam Altman's venture), offering candid insights about which approaches show the most promise and why Google's Calico has struggled despite substantial resources.Regulatory innovation emerges as a crucial accelerator for progress. Montana's groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50-50 chance of reaching "longevity escape velocity" within 12-15 years. This would enable taking 60-year-olds and rejuvenating them enough that they wouldn't be biologically 60 again for another 20 years, during which time further advances would enable additional rejuvenation cycles—potentially creating open-ended healthy lifespans for many alive today.Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Apr 8, 2025 • 30min
On Healing with Dr Amitha Kalaichandran
What if healing isn't the same as curing? Dr. Amita Kalaichandran draws from her unique background in conventional medicine, public health, integrative approaches, and journalism to reshape our understanding of true wellness in ways that might surprise you.At the heart of this conversation lies a powerful distinction: while Western medicine excels at curing (removing disease), healing represents something far more profound—a return to wholeness that integrates illness and challenges into our lives. Amitha thoughtfully explains why even those facing terminal conditions can find healing, creating meaning and wholeness right through the end of life. This perspective challenges our cultural tendency to view death as simply "losing the battle" with disease.The discussion moves into fascinating territory exploring psychological safety in healthcare settings. Drawing from Amy Edmondson's groundbreaking research, we discover how the ability to speak up without fear creates not just better patient outcomes, but also nurtures innovation and prevents provider burnout. This concept extends beyond hospitals into every workplace, where a sense of belonging and voice directly impacts both individual health and organizational success.Perhaps most intriguing is Amitha's nuanced take on psychedelics as healing tools. She explains how substances like psilocybin and MDMA might work on the brain's default mode network to "untangle the knots" of fossilized thought patterns where traditional therapies sometimes fail. The conversation acknowledges both the promising research and necessary cautions while suggesting that these compounds might offer flexibility in thinking that many of us lose as we age.Don't miss this rich exploration of healing that weaves together cutting-edge science, ancient wisdom, and practical insights for anyone seeking a more integrated approach to wellness. Subscribe now and join us in reimagining what healing truly means for body, mind, and spirit.Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Apr 1, 2025 • 31min
The Truth About Complex Chronic Illness with Eric Gordon
This week Dr. Eric Gordon returns to our program to draw back the curtain on chronic complex illness, illuminating the profound yet often overlooked connection between interrupted healing cycles and persistent health problems that conventional medicine struggles to address.At the heart of conditions like chronic fatigue syndrome, Lyme disease, and atypical autoimmune disorders lies chronic inflammation—not as a symptom, but as the driving force. Gordon explains that these debilitating conditions manifest when your body fails to complete its natural healing cycle, leaving millions with normal blood tests but life-altering fatigue, pain, and cognitive dysfunction.The revolutionary "cell danger response" framework reveals why your cells get stuck in defensive postures long after threats have passed. Your mitochondria aren't broken—they've adaptively changed their function, which explains why supplements often disappoint chronic illness sufferers. This three-phase healing cycle (inflammation, rebuilding, and cellular communication restoration) must complete for true recovery, yet medicine focuses almost exclusively on the first phase.What makes Gordon's perspective particularly valuable is his recognition that feeling safe is fundamental to healing. The nervous system must receive signals that it's appropriate to divert resources toward restoration rather than protection. This explains why stress reduction becomes increasingly crucial the longer someone remains ill—chronic inflammation itself increases anxiety, creating a destructive feedback loop that further impedes recovery.Medicine's blind spot stems from its overwhelming focus on acute care models. We excel at addressing immediate threats like infections or injuries, but pay minimal attention to the complex, individualized healing process that must follow. This cookbook approach fails because biochemical individuality means each person's body responds uniquely to identical interventions.Ready to understand why your chronic symptoms persist despite normal tests? Discover how addressing the complete healing cycle might finally unlock the recovery that's eluded you for years.Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Mar 25, 2025 • 37min
Reversing Alzheimer's with Dr Dale Bredesen
What if everything we've been told about Alzheimer's disease is backwards? Dr. Dale Bredesen, author of the New York Times bestseller "The End of Alzheimer's," returns to our program to shatter conventional wisdom with research showing cognitive decline can be prevented and even reversed.The traditional approach to Alzheimer's has failed spectacularly. Despite billions in research funding, pharmaceutical solutions have delivered minimal benefits. Why? Dr. Bredesen reveals the fundamental misunderstanding: Alzheimer's isn't a single-cause disease requiring a single drug, but rather a complex brain response to multiple insults. What we call Alzheimer's represents a "cytokine drizzle" – chronic, low-grade inflammation forcing the brain to downsize its synaptic network.Most surprisingly, amyloid – long considered the villain – is actually part of your brain's defense system! It creates "little igloos" around pathogens that have invaded brain tissue. This revolutionary understanding points to a completely different approach to prevention and treatment.Dr. Bredesen's protocol addresses the true underlying causes: insufficient energetics/support, excessive inflammation, and toxin exposure. His published research shows 84% of patients experience improvement, with benefits sustained for over a decade in many cases. Even advanced cases show meaningful functional gains – one patient is continent while on the protocol and incontinent when off it!Want to live to 100 or beyond with a sharp mind? This conversation is essential listening. Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Mar 18, 2025 • 42min
Decentralizing Health and Longevity
What if the future of healthcare lies in our ability to decentralize it? This episode takes us on an insightful journey with Jasmine Smith, the visionary CEO of Rejuve AI. She shares her fascinating transition from health information management to leading a groundbreaking project in decentralized health and wellness. The transformation from Web 2.0 to Web 3.0 is laid bare, with Jasmine revealing how this evolution empowers individuals by taking control away from traditional central entities and addressing challenges like scalability and user experience. We also uncover how technologies such as IPFS and Filecoin are poised to revolutionize sectors like healthcare, particularly in data handling and security.We venture into the intersection of AI, blockchain, and longevity research through Rejuve AI's decentralized platform. This network ambitiously crowdsources health data from users, leveraging wearable devices and health surveys, with future plans for genomic data integration. By personalizing health protocols, Rejuve AI aims to deepen users' understanding of their physiological data, marking a significant stride toward democratizing health information. There's a burgeoning movement toward decentralized science, with comparisons drawn to initiatives like Matt Kaberlein's crowdsource database for rapamycin and VitaDAO's innovative research efforts.As we explore decentralized science further, the episode delves into how it fosters fairness, reduces bias, and accelerates research, especially in the field of aging. VitaDAO's novel approach to funding biotech startups through tokenized intellectual property is highlighted, offering a glimpse into the future of rapid therapy development. The synergy between VitaDAO and Rejuve AI is palpable, with both entities pushing the boundaries of health innovation. Listeners can anticipate the launch of the Rejuve AI app in early 2025, a tool designed to enhance user health and longevity through a freemium model backed by the RJV token. These initiatives are set to transform healthcare into a more collaborative and data-driven industry, promising a healthier future for all.https://www.rejuve.ai/Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Mar 11, 2025 • 48min
Junk Food Dangers with Robert Lustig
This week we unlock the secrets to a healthier, longer life with insights from Dr Robert Lustig as he unpacks the hidden dangers of junk food. Ever wondered how ultra-processed foods sabotage your body's natural functions? Discover how the fructose in these foods disrupts your mitochondria, leading to serious health issues like fatty liver disease and insulin resistance. Dr Lustig contrasts these effects with the benefits of whole fruits, which offer protective fibers to mitigate damage, equipping you with the knowledge to make smarter dietary choices.Join us as we challenge outdated medical beliefs and shed light on the profound connection between sugar and hypertension. By understanding the role of insulin in sodium retention and how reducing sugar intake can better manage blood pressure, you'll gain a fresh perspective on effective dietary interventions. We'll also delve into the transformation of glucose to fructose via the polyol pathway, and how this contributes to increased uric acid levels and impacts blood pressure regulation by inhibiting nitric oxide formation, based on Richard Johnson’s research.Explore the fascinating world of fats and fibers with us, as we reexamine the impacts of different lipids and introduce innovative solutions to modern dietary issues. We'll clarify misconceptions about saturated fats and highlight the benefits and risks of omega-3 and omega-6 fatty acids. Dr. Lustig explains the importance of fiber in maintaining gut health and reducing inflammation, offering practical solutions to counteract the negative impacts of ultra-processed foods. Get ready to revolutionize your understanding of diet and its profound impact on your health.Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Mar 4, 2025 • 41min
Rethinking Cancer Treatment
Conventional cancer therapies may be missing additional opportunities for healing. The recent breakthrough publication showing brain cancer three year survival rates of 66% on a ketogenic diet versus 8% on a regular diet highlight this possibility. [https://t.co/dsU7hD71Wv]This week we discover why our guest believes the real battle against cancer is fought at the metabolic level, not through DNA-focused treatments. Join me as we sit down with Dr. Katie Deming, a former radiation oncologist who has completely redefined her approach to cancer care. After experiencing a life-altering event that shifted her perspective, Katie now champions a holistic methodology she calls conscious oncology. We break down her innovative views on cancer's root causes—suggesting that the true culprit lies in mitochondrial dysfunction, not DNA mutations. Katie draws upon groundbreaking research and personal insights to argue that emotional trauma and stress significantly contribute to physical illnesses, including cancer.In this eye-opening episode, we also touch on fascinating insights from experts like Thomas Seyfried and Kelly Turner, examining how strategies like ketogenic diets and emotional healing can lead to remarkable improvements in cancer outcomes. Katie and I discuss alternative methods like plant medicine and fasting, focusing on the body's innate ability to heal when properly supported. Whether it's through detoxification, nutritional balance, or addressing emotional scars, this conversation provides a comprehensive view of cancer treatment that challenges conventional methods and emphasizes each individual's unique healing journey. Listen in to explore how aligning health strategies with personal values can create a transformative path to healing.https://www.katiedeming.com/Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Feb 25, 2025 • 37min
The Longevity Mindset
What if adopting a new mindset could transform not just how long you live, but how well you live? Join us as we explore this possibility with Dr. Nick Engerer, a leading expert on longevity and health optimization. Drawing from his personal journey that started with a wake-up call in his twenties, Dr. Engerer reveals the secrets to embracing a longevity mindset. Through his experiences with cutting-edge technologies at Human Longevity Inc., he shares how early disease detection is revolutionizing healthcare, offering insights that could change how we approach aging and wellness.We discover the profound impact of living with purpose and maintaining a positive outlook on aging. We’ll share stories of vibrant individuals who defy the expectations of growing older, illustrating that lifestyle choices like quality sleep, exercise, and nutrition are just the beginning. Dr. Engerer emphasizes the critical role of understanding your genetic makeup and family history, empowering you to take control of your health like never before. From Martha Stewart to the Rolling Stones, you'll hear how a sense of purpose can keep you thriving well into your golden years.This episode is our gateway to the future of health as we discuss exciting longevity technologies and self-experimentation. Dr. Engerer talks about his rebranded blog, "A Longer Life with Nick Engerer," as a treasure trove of resources for those eager to master the art of longevity. Get a sneak peek into our upcoming docuseries filmed in Costa Rica, featuring insights from longevity experts worldwide. Whether you're looking to enhance your lifespan or simply live a more fulfilling life, this conversation is a must-listen for anyone interested in taking charge of their health destiny.https://www.nickengerer.org/Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Feb 18, 2025 • 35min
Fructose Dangers
This week we get to unlock the secret to better health with Dr. Richard Johnson, a leading mind in the field of sugar metabolism, as he reveals the hidden dangers of fructose and its surprising role in metabolic diseases. Dive into the science of sugars and uncover the biological mechanisms that make fructose a stealthy culprit for obesity. While fruits like dates and figs may seem harmless, their high fructose content is a concern, especially when consumed in juices. Dr. Johnson demystifies the connection between sugar and fat storage, and why the body mistakenly believes it's low on energy, leading to weight gain.Explore the fascinating interplay between fructose, salt, and carbohydrates, and learn how these elements influence blood pressure and metabolic health. Discover why a low-carb or keto diet might be your best defense against the adverse effects of salt and uric acid. We also navigate the world of sugar substitutes, with a spotlight on allulose, a promising alternative. We also discuss Dr. Johnson's informative book "Nature Wants Us to Be Fat" for further reading on this critical healthcare topic.https://drrichardjohnson.com/ (20% off using DrLufkin20): https://rxsugar.com/discount/DrLufkin20Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...
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