Health Longevity Secrets

Robert Lufkin MD
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Aug 12, 2025 • 42min

Is Rapamycin the Best Longevity Drug? with Dr Rick Cohen

Dive into the fascinating world of longevity research as we explore rapamycin, potentially the most powerful anti-aging pharmaceutical currently known. Dr. Rick Cohen, longevity physician with over 25 years of experience, reveals how this natural molecule discovered on Easter Island targets a fundamental cellular pathway called mTOR that acts as our body's metabolic switch between growth and repair.This episode is sponsored by Gatlan who makes rapamycin that we will be discussing available in their program. I am an advisor to Gatlan but I only advise companies that I believe in and would use for myself and my family. The conversation uncovers the remarkable story behind rapamycin's discovery - how it sat forgotten in a researcher's freezer for years before its life-extending properties were recognized. Dr. Rick explains that mTOR has been conserved through billions of years of evolution precisely because it's so critical to survival, sensing nutrient availability and telling cells whether to grow or repair themselves.What makes this discussion particularly valuable is Dr. Rick's practical approach to using rapamycin as a metabolic health tool rather than a miracle drug. He shares insights on proper dosing strategies, emphasizing the importance of cycling between periods of mTOR suppression and activation to mimic natural patterns our bodies evolved with. This cycling approach - perhaps taking rapamycin for a few months, then taking a month off for anabolic growth through strength training - may be key to optimizing its benefits.The breadth of rapamycin's benefits is truly remarkable - from hair regrowth and skin rejuvenation to improvements in hearing, fertility, and protection against diseases ranging from Alzheimer's to atherosclerosis. This suggests rapamycin isn't just treating symptoms but addressing a fundamental mechanism of aging itself.Ready to understand how this single pathway could influence every aspect of how we age? Listen now to discover why balancing growth and repair cycles might be the key to extending your healthspan and potentially your healthspan and potentially your lifespan.https://www.gatlan.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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Aug 5, 2025 • 41min

Is Bioidentical Hormone Replacement: The Missing Piece to Your Health Puzzle?

What if the key to feeling better at 45 than you did at 25 isn't about accepting "normal" lab values, but about optimizing your hormones to their ideal levels? In this eye-opening conversation, Dr. Lauren Fitzgerald—a board-certified anesthesiologist who now specializes in bioidentical hormone replacement therapy—challenges conventional medical wisdom about hormone health.Dr. Fitzgerald breaks down the critical difference between bioidentical hormones and non-bioidentical versions. This distinction isn't just academic—it has profound implications for safety and effectiveness. While your doctor might tell you your hormone levels are "normal," those ranges often represent the average of an increasingly unhealthy population, not optimal levels for vitality and longevity.Contrary to lingering misconceptions from outdated studies, bioidentical hormone replacement therapy has been shown to decrease cancer risk, protect cardiovascular health, prevent osteoporosis, and support cognitive function. For both women navigating perimenopause and men experiencing age-related testosterone decline, properly administered bioidentical hormones can transform quality of life. Whether you're struggling with brain fog, fatigue, weight issues, or just don't feel like your vibrant self anymore, this conversation offers a roadmap to reclaiming your energy and zest for life through evidence-based hormone optimization.https://larimarmed.com/.  @worldlinkhttps://worldlinkmedical.com/education/conferences/academic-summit-2025Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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Jul 29, 2025 • 33min

Why Measure Erections?

Unlock the secrets of male well-being with Christos Konstantinidis, the pioneering founder and CEO of Adam Health, as we unveil the profound link between erectile health and holistic male wellness. Discover how your body's signals, often overlooked, could be the earliest indicators of serious health concerns like cardiovascular disease. Christos provides enlightening insights into how erectile function serves as a critical health barometer, cutting across cardiovascular, neurological, and hormonal domains.Explore the natural phenomena of nighttime erections and their vital role in sustaining erectile health, as well as the promise held by erectile dysfunction drugs in potentially extending lifespan and reducing the risk of chronic illnesses such as Alzheimer's. With Christos's expert guidance, learn about groundbreaking tools like Adam Health's erection health tracker, designed to empower men in managing their sexual health proactively. Don't miss out on the array of solutions available to tackle erectile issues, from PDE5 inhibitors to cutting-edge rejuvenation treatments, all aimed at improving quality of life and fostering an open dialogue about men's health.https://talktoadam.comLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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Jul 22, 2025 • 54min

Does Mitochondrial Transplantation Work?

What if we could reset our cellular batteries? In this fascinating deep dive into cutting-edge longevity science, Tom Benson from Mitrix Bio reveals how mitochondrial transplantation could revolutionize how we treat age-related diseases and potentially add decades of healthy living to our lives.The conversation begins by exploring the extraordinary nature of mitochondria – those tiny power plants within our cells that generate 95% of our body's energy through molecular rotors functioning like miniature jet turbines. With approximately a quadrillion mitochondria comprising 10% of our body weight, these ancient organelles trace back to a symbiotic merger with our cellular ancestors over a billion years ago.Unlike the nuclear DNA we inherit from both parents, our mitochondrial DNA comes almost exclusively from our mothers, creating fascinating maternal lineage patterns where thousands of family members share identical mitochondrial DNA. As we age, this mitochondrial DNA gradually accumulates damage, with factors like stress, smoking, and medical treatments accelerating deterioration. By our 90s, this decline reaches a critical threshold that appears to drive much of the aging process.The most exciting revelation comes in learning that mitochondria naturally move between cells in our bodies – and scientists are now leveraging this phenomenon through transplantation techniques. By harvesting mitochondria from stem cells grown in bioreactors and reinjecting them, researchers are seeing remarkable improvements in cognition, strength, and immune function in aged mice, essentially restoring youthful cellular energy levels. Human trials are already underway, though still at small scale.For anyone fascinated by the frontiers of longevity science and the quest to not just add years to life, but life to those years, this conversation offers a glimpse into one of the most promising approaches emerging today. https://mitrix.bio/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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16 snips
Jul 15, 2025 • 47min

Oral Testosterone For Better Health with Dr Andrew Sun

Join Dr. Andrew Sun, a fellowship-trained andrology specialist and director of a Texas Men's Health Center, as he uncovers the multifaceted benefits of testosterone beyond bodybuilding. He shares how factors like poor sleep can impact testosterone levels even in younger men. Discover the innovative oral testosterone therapy, Kyzatrex, designed to align with natural rhythms while minimizing side effects. Dr. Sun emphasizes the importance of personalized treatment approaches and debunks myths linking testosterone to prostate cancer, advocating for a holistic view of men’s health.
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Jul 8, 2025 • 50min

The Power of Functional Medicine with Dr. Mark Hyman

Ever wondered if you can truly turn back the clock on aging? Join us in this compelling episode as Dr. Mark Hyman shares his extraordinary insights on the power of functional medicine to rejuvenate the body and mind at any age. Discover how Dr. Hyman's personal and professional journey led him to uncover the foundational causes of aging and chronic disease, and learn about the vital distinctions between beneficial and harmful stress. We also delve into the fascinating concept of biological versus chronological aging and the transformative potential of lifestyle choices in reversing biological age.This episode is sponsored by Rio.life. I am an advisor to Rio but I only advise companies that I believe in and would use for myself and my family. Our discussion takes a critical look at the current healthcare and medical education systems, shedding light on how profit-driven motives can undermine simple, effective treatments. Dr. Hyman introduces the concept of hormesis, explaining how small, beneficial stresses like intermittent fasting, cold showers, and saunas can activate the body's innate healing mechanisms. We underscore the crucial role of modern nutritional science in medical education, arguing for a more integrated approach that places lifestyle and diet at the core of health management.In our final deep dive, we explore the complex relationship between aging, inflammation, and nutrition. Dr. Hyman discusses the hallmarks of aging and the importance of balancing what the body has too much of and what it lacks. This includes the impact of refined oils versus traditional oils, the benefits of higher protein intake for older adults, and the emerging technology of continuous glucose monitors. We also touch on the profound influence of social connections on health and longevity.https://www.functionhealth.com/.         https://www.rio.life/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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Jul 1, 2025 • 40min

Stem Cells For Longevity with Dr Vincent Giampapa

This week we are broadcasting a fascinating presentation from my good friend Dr Vincent Giampapa where he discusses the potential and actual use of stem cell therapy for longevity. I have had the pleasure of visiting his remarkable longevity center in San Jose Costa Rica. We will be having a dedicated upcoming episode about it. This presentation is from the most recent RAADFEST meeting which is set to take place again in Las Vegas on July 10-13. You won't want to miss it! https://www.raadfest.com/Prepare to be captivated by the insights of Dr. Vincent C. Giampappa, a trailblazer in anti-aging medicine and technology, as we uncover the secrets behind the rapid advancements in this field. With aging-related knowledge doubling every three months, Vince emphasizes the urgency of maintaining good health to fully benefit from these breakthroughs. We explore the compelling concept of biological clocks within the human body, from the central aging clock in the hypothalamus to peripheral clocks in stem and somatic cells, and how our lifestyles and genetics can influence these pivotal systems.In a thought-provoking discussion, we delve into emerging therapies in aging medicine, focusing on the regenerative power of the body's stem cells. Vince unveils promising therapies like umbilical cord stem cell infusions and gene-enhanced stem cell functions, potentially restoring lost functions and extending our healthspan. We also dive into the groundbreaking world of gene therapy techniques, including viral vectors, plasmids, and even the potential of creating artificial chromosomes, all paving the way for revolutionary therapeutic strategies in combating aging.As we venture into the future of stem cell therapy, we explore the concept of "bioinsurance" and the transformative impact of AI and quantum computing on medical research. Imagine a world where you can bank your stem cells for future use, slowing the aging process and enhancing overall health. We conclude with the empowering notion of personalized therapies, where you can actively choose your path in the realm of anti-aging and regenerative medicine. Tune in to discover how these advancements promise to redefine our understanding of aging and renew our vision of maintaining independence and vitality throughout life.https://drgiampapa.org/      https://www.rmihealth.com/.  https://www.raadfLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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Jun 24, 2025 • 1h 2min

Spermidine: The Autophagy Activator with Dr Melissa Cano

As we near the end of the school year, I'd like to give a shoutout to Mr George Gaskin's 7th grade history class at Harvard-Westlake School who are fans of this program. Have you ever wondered what keeps your cells functioning properly? The answer might be a molecule with a funny name but serious implications for longevity. Spermidine, found in every living cell on Earth, is essential for triggering autophagy—your body's internal cleaning system that recycles damaged cellular components.Biochemist Dr. Melissa Cano takes us deep into the fascinating world of cellular metabolism, explaining how this small but mighty molecule could be key to healthier aging. Our spermidine levels naturally decline as we age, precisely when we need its protective effects most. This decline happens through three pathways: diminished internal production, changes in gut microbiome, and potentially decreased absorption from food—creating a perfect storm for cellular aging.What makes this conversation particularly compelling is the growing body of evidence supporting spermidine's role in longevity. Epidemiological studies show people with higher dietary spermidine intake live 5-10 years longer on average. In lab studies, supplementation extends lifespan in multiple organisms by 5-20%. A groundbreaking 2024 study in Nature Cell Biology even revealed that spermidine mediates many of fasting's benefits—suggesting this molecule could be a natural caloric restriction mimetic without the hunger.Whether you're already familiar with longevity compounds like rapamycin and metformin or just beginning your healthy aging journey, this episode offers practical insights for everyone.  Ready to support your body's natural cleaning and rejuvenation processes? Learn how this remarkable molecule works at the cellular level and discover if spermidine supplementation might be the missing piece in your longevity strategy.This episode is sponsored by SpermidineLife whose products are mentioned in the program.  Use promo code ROB15 for discount. https://spermidinelife.us/products/spermidinelife-extra-dietary-supplement?utm_source=Lufkin&utm_medium=podcastLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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Jun 17, 2025 • 45min

How Food Affects Mental Health with Dr Christopher Palmer

Dr. Christopher Palmer is a friend and regular guest on this program and he never disappoints.  This week he takes us on a fascinating journey through the groundbreaking connection between metabolism and mental health, revealing how the foods we eat profoundly impact not just our bodies but our minds. As a Harvard psychiatrist and director of the Metabolic and Mental Health Program at McLean Hospital, Chris shares compelling evidence that many psychiatric conditions may fundamentally be disorders of brain energy.The conversation opens with alarming statistics about our growing mental health crisis - from quadrupling autism rates to skyrocketing depression and anxiety - and connects these trends to parallel increases in metabolic diseases like diabetes and obesity. Chris explains how these seemingly separate epidemics share common biological roots in cellular energy production.Most powerfully, Chris shares transformative case studies from his clinical practice, including a patient with treatment-resistant schizoaffective disorder whose hallucinations and delusions improved dramatically on a ketogenic diet. These experiences aren't isolated incidents but reflect a growing body of research suggesting ketogenic diets can beneficially alter brain chemistry by improving mitochondrial function - the cellular powerhouses responsible for energy production.The discussion extends beyond serious mental illness to everyday struggles like burnout, anxiety, and depression. An orthopedic surgeon contemplating early retirement due to severe burnout completely revitalized his passion for medicine through metabolic interventions - highlighting how energy deficits at the cellular level manifest as psychological symptoms that conventional treatments often fail to address.Visit brainenergy.com to access free resources, take Dr. Palmer's self-assessment, and learn more about the revolutionary field of metabolic psychiatry that's offering new hope to millions suffering from treatment-resistant mental health conditions.This episode is sponsored by Rio.life which emphasizes metabolically healthy food choices in their programs. I am an advisor to Rio but I only advise companies that I believe in and would use for myself and my family. brainenergy.com    rio.lifeLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...
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Jun 10, 2025 • 37min

Is There a Central Aging Clock with Dr. Sheldon Jordan

This week we are broadcasting a fascinating presentation from my good friend Dr Shelly Jordan where he discusses not only the importance of a central aging clock but also a possible treatment to reset it. He has even offered the procedure to me. Please let me know if you think I should take him up on his offer.This presentation is from the most recent RAADFEST meeting which is set to take place again in Las Vegas on July 10-13. You won't want to miss it!We get to unlock the secrets of aging with the intriguing insights of Dr. Sheldon Jordan, a distinguished neurologist and professor. We journey through the concept of the "Grim Reaper clock," exploring how a central brain clock might dictate the course of our lives, from puberty to menopause and beyond. Through the thoughtful lens of the "grandma hypothesis," we ponder how slow aging could have provided humans an edge in adapting to environmental shifts.Prepare to challenge what you think you know about aging as we navigate the intricate relationship between age and performance. Why might athletes and intellectuals peak so early, and what role do the hypothalamus and pineal gland play in maintaining our youth? Learn about the groundbreaking research by Dr. Kai, potentially reversing aging by using exosomes in mice, and explore innovative techniques like genetic reprogramming and ultrasound technology to influence mental health. We consider how transposons might impact age-related diseases and discuss the tantalizing possibility of controlling the aging process itself. This episode offers a glimpse into a future where medical science could redefine what it means to grow old.https://www.neurologysantamonica.com/https://www.raadfest.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

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