
Health Longevity Secrets
A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including longevity, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, consciousness, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe and get ready to change your life. HLS is hosted by Robert Lufkin MD, a physician/medical school professor and New York Times Bestselling auhtor focusing on the applied science of health and longevity through lifestyle and other tools in order to cultivate consciousness, and live life to the fullest .'Envision a world of love, abundance, and generosity'.
Latest episodes

May 13, 2025 • 45min
Metabolic Freedom with Ben Azadi
What if your body wasn't designed to be sick? What if those nagging symptoms you've been fighting aren't problems at all, but messages—your body's desperate attempt to communicate that something deeper needs attention?In this revealing conversation, metabolic health expert and my good friend Ben Azadi introduces his new book "Metabolic Freedom," explaining why an astonishing 93% of Americans are metabolically unhealthy and what we can do about it. Rather than focusing on niche approaches like strict keto or extended fasting, Azadi presents a comprehensive framework accessible to everyone, addressing the five root causes behind metabolic dysfunction.One of the most alarming revelations? You could have full-blown insulin resistance for 6-14 years while still showing "perfect" blood sugar readings on standard tests. Your pancreas compensates by pumping out massive amounts of insulin until it simply can't keep up anymore. By then, you're already deep in the disease process. Ben makes a compelling case for requesting fasting insulin tests rather than relying solely on glucose measurements that miss this critical early warning.The conversation explores how true metabolic freedom means having a body that can effortlessly use whatever fuel is available—carbs, protein, fat, or stored body fat—to generate steady energy without constant snacking or stimulants. Ben breaks down the powerful healing cascade that happens during fasting, from completed digestion at 14 hours to enhanced cellular cleanup (autophagy) at 16-17 hours and increased brain-derived neurotrophic factor at the 24-hour mark.Beyond food timing, we look at the devastating impact of environmental toxins he classifies as "obesogens" and "diabetogens"—compounds found in everything from plastic containers to cash register receipts that directly promote weight gain and blood sugar dysfunction. Whether you're just beginning your health journey or deeply familiar with metabolic concepts, this conversation offers practical wisdom for reclaiming your body's natural state of health through a 30-day plan designed to restore your metabolic freedom.https://www.benazadi.com/Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

May 6, 2025 • 57min
Fasting Against Cancer with Dr Katie Deming
Dr. Katie Deming, a former radiation oncologist turned advocate for alternative cancer treatments, reveals how cancer may be a metabolic condition rather than solely genetic. She discusses the impact of ketogenic diets and supervised water fasting in targeting cancer cells by cutting off their primary fuel, glucose. Alongside physical healing, she highlights fasting's transformative emotional and spiritual benefits. Listeners learn about the holistic advantages of fasting and its potential as a complementary therapy alongside conventional cancer treatments.

Apr 29, 2025 • 1h 6min
Molecular Hydrogen: Breakthrough or Hype?
Could a simple molecule be the key to resolving seemingly incurable health conditions? Greg shares his remarkable journey from facing imminent death to complete recovery using molecular hydrogen therapy. After conventional medicine failed to treat his tumors, severe heart condition, and debilitating autoimmune issues, Greg's desperate search led him to discover what he believes to be the profound healing potential of properly administered molecular hydrogen.Unlike conventional antioxidants, molecular hydrogen (H2) is thought to work selectively in the body—including on the mitochondria, where many diseases originate. Greg explains how hydrogen's uniquely small molecular size allows it to penetrate any cell in the body, crossing the blood-brain barrier and working at the cellular level to reduce inflammation, improve nutrient absorption, and restore proper function to various systems.Greg shares remarkable case studies, from a woman with dementia who regained her ability to recognize family members to patients with supposedly permanent heart conditions seeing complete reversals. More work is clearly needed in this area of evidence to move beyond anecdotal case reports to clinical trials. We explore the science behind different hydrogen delivery methods, why production quality matters tremendously, and practical protocols anyone can implement. Greg offers valuable guidance on avoiding inferior products that might introduce harmful byproducts while explaining how proper hydrogen therapy might be the missing piece in your health journey.Whether you're battling chronic health issues or simply interested in optimizing your wellness and longevity, this episode challenges conventional thinking about healing and recovery. We are at the beginning of understanding the science behind molecular hydrogen therapy and will be paying close attention as this story continues to unfold.This episode was sponsored by holyhydrogen.com maker of one of the devices described in this show. https://holyhydrogen.com/Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Apr 22, 2025 • 39min
Why Calories Don't Count with Dr Giles Yeo
Dr. Giles Yeo, Cambridge University Professor, author of "Why Calories Don't Count," and Chief Science Advisor at Rio demolishes weight management myths with scientific precision and personal warmth. This mind-shifting conversation reveals why blaming people for obesity fundamentally misunderstands human biology. Full disclosure: I am also an advisor for Rio but I only work with companies I believe in and would use for myself and my family.Bold scientific insights abound as Dr. Yeo reveals why simple calorie counting fails. Rather than fixating on calories, he advocates understanding how different foods affect our bodies uniquely, making a compelling case for cooking at home with quality ingredients as his personal health strategy.The discussion ventures into today's most transformative weight management tools, with Dr. Yeo describing GLP-1 medications as the most effective treatment options he's encountered in 30 years of obesity research. These medications signal fullness to the brain, but surprisingly affect other reward-seeking behaviors too - from alcohol consumption to addictive tendencies. The conversation explores fascinating frontiers in brain science, including Dr. Yeo's groundbreaking work mapping human hypothalamus feeding circuits, and examines how AI-assisted health applications might revolutionize personalized nutrition. Throughout, his compassionate message resonates: obesity isn't a character flaw - it's the result of biological and environmental factors that require understanding, not judgment. Discover why this disco-dancing geneticist believes personalized approaches, not quick fixes, are the future of health optimization.https://rio.life/Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Apr 15, 2025 • 41min
The Future of Aging with Aubrey de Grey
Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that's gaining mainstream scientific acceptance after initial skepticism.The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider's assessment of major players including HEvolution (Saudi-backed), Altos Labs (Bezos-funded), Calico (Google-funded) and Retro Biosciences (Sam Altman's venture), offering candid insights about which approaches show the most promise and why Google's Calico has struggled despite substantial resources.Regulatory innovation emerges as a crucial accelerator for progress. Montana's groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50-50 chance of reaching "longevity escape velocity" within 12-15 years. This would enable taking 60-year-olds and rejuvenating them enough that they wouldn't be biologically 60 again for another 20 years, during which time further advances would enable additional rejuvenation cycles—potentially creating open-ended healthy lifespans for many alive today.Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Apr 8, 2025 • 30min
On Healing with Dr Amitha Kalaichandran
What if healing isn't the same as curing? Dr. Amita Kalaichandran draws from her unique background in conventional medicine, public health, integrative approaches, and journalism to reshape our understanding of true wellness in ways that might surprise you.At the heart of this conversation lies a powerful distinction: while Western medicine excels at curing (removing disease), healing represents something far more profound—a return to wholeness that integrates illness and challenges into our lives. Amitha thoughtfully explains why even those facing terminal conditions can find healing, creating meaning and wholeness right through the end of life. This perspective challenges our cultural tendency to view death as simply "losing the battle" with disease.The discussion moves into fascinating territory exploring psychological safety in healthcare settings. Drawing from Amy Edmondson's groundbreaking research, we discover how the ability to speak up without fear creates not just better patient outcomes, but also nurtures innovation and prevents provider burnout. This concept extends beyond hospitals into every workplace, where a sense of belonging and voice directly impacts both individual health and organizational success.Perhaps most intriguing is Amitha's nuanced take on psychedelics as healing tools. She explains how substances like psilocybin and MDMA might work on the brain's default mode network to "untangle the knots" of fossilized thought patterns where traditional therapies sometimes fail. The conversation acknowledges both the promising research and necessary cautions while suggesting that these compounds might offer flexibility in thinking that many of us lose as we age.Don't miss this rich exploration of healing that weaves together cutting-edge science, ancient wisdom, and practical insights for anyone seeking a more integrated approach to wellness. Subscribe now and join us in reimagining what healing truly means for body, mind, and spirit.Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Apr 1, 2025 • 31min
The Truth About Complex Chronic Illness with Eric Gordon
This week Dr. Eric Gordon returns to our program to draw back the curtain on chronic complex illness, illuminating the profound yet often overlooked connection between interrupted healing cycles and persistent health problems that conventional medicine struggles to address.At the heart of conditions like chronic fatigue syndrome, Lyme disease, and atypical autoimmune disorders lies chronic inflammation—not as a symptom, but as the driving force. Gordon explains that these debilitating conditions manifest when your body fails to complete its natural healing cycle, leaving millions with normal blood tests but life-altering fatigue, pain, and cognitive dysfunction.The revolutionary "cell danger response" framework reveals why your cells get stuck in defensive postures long after threats have passed. Your mitochondria aren't broken—they've adaptively changed their function, which explains why supplements often disappoint chronic illness sufferers. This three-phase healing cycle (inflammation, rebuilding, and cellular communication restoration) must complete for true recovery, yet medicine focuses almost exclusively on the first phase.What makes Gordon's perspective particularly valuable is his recognition that feeling safe is fundamental to healing. The nervous system must receive signals that it's appropriate to divert resources toward restoration rather than protection. This explains why stress reduction becomes increasingly crucial the longer someone remains ill—chronic inflammation itself increases anxiety, creating a destructive feedback loop that further impedes recovery.Medicine's blind spot stems from its overwhelming focus on acute care models. We excel at addressing immediate threats like infections or injuries, but pay minimal attention to the complex, individualized healing process that must follow. This cookbook approach fails because biochemical individuality means each person's body responds uniquely to identical interventions.Ready to understand why your chronic symptoms persist despite normal tests? Discover how addressing the complete healing cycle might finally unlock the recovery that's eluded you for years.Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Mar 25, 2025 • 37min
Reversing Alzheimer's with Dr Dale Bredesen
What if everything we've been told about Alzheimer's disease is backwards? Dr. Dale Bredesen, author of the New York Times bestseller "The End of Alzheimer's," returns to our program to shatter conventional wisdom with research showing cognitive decline can be prevented and even reversed.The traditional approach to Alzheimer's has failed spectacularly. Despite billions in research funding, pharmaceutical solutions have delivered minimal benefits. Why? Dr. Bredesen reveals the fundamental misunderstanding: Alzheimer's isn't a single-cause disease requiring a single drug, but rather a complex brain response to multiple insults. What we call Alzheimer's represents a "cytokine drizzle" – chronic, low-grade inflammation forcing the brain to downsize its synaptic network.Most surprisingly, amyloid – long considered the villain – is actually part of your brain's defense system! It creates "little igloos" around pathogens that have invaded brain tissue. This revolutionary understanding points to a completely different approach to prevention and treatment.Dr. Bredesen's protocol addresses the true underlying causes: insufficient energetics/support, excessive inflammation, and toxin exposure. His published research shows 84% of patients experience improvement, with benefits sustained for over a decade in many cases. Even advanced cases show meaningful functional gains – one patient is continent while on the protocol and incontinent when off it!Want to live to 100 or beyond with a sharp mind? This conversation is essential listening. Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Mar 18, 2025 • 42min
Decentralizing Health and Longevity
What if the future of healthcare lies in our ability to decentralize it? This episode takes us on an insightful journey with Jasmine Smith, the visionary CEO of Rejuve AI. She shares her fascinating transition from health information management to leading a groundbreaking project in decentralized health and wellness. The transformation from Web 2.0 to Web 3.0 is laid bare, with Jasmine revealing how this evolution empowers individuals by taking control away from traditional central entities and addressing challenges like scalability and user experience. We also uncover how technologies such as IPFS and Filecoin are poised to revolutionize sectors like healthcare, particularly in data handling and security.We venture into the intersection of AI, blockchain, and longevity research through Rejuve AI's decentralized platform. This network ambitiously crowdsources health data from users, leveraging wearable devices and health surveys, with future plans for genomic data integration. By personalizing health protocols, Rejuve AI aims to deepen users' understanding of their physiological data, marking a significant stride toward democratizing health information. There's a burgeoning movement toward decentralized science, with comparisons drawn to initiatives like Matt Kaberlein's crowdsource database for rapamycin and VitaDAO's innovative research efforts.As we explore decentralized science further, the episode delves into how it fosters fairness, reduces bias, and accelerates research, especially in the field of aging. VitaDAO's novel approach to funding biotech startups through tokenized intellectual property is highlighted, offering a glimpse into the future of rapid therapy development. The synergy between VitaDAO and Rejuve AI is palpable, with both entities pushing the boundaries of health innovation. Listeners can anticipate the launch of the Rejuve AI app in early 2025, a tool designed to enhance user health and longevity through a freemium model backed by the RJV token. These initiatives are set to transform healthcare into a more collaborative and data-driven industry, promising a healthier future for all.https://www.rejuve.ai/Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

Mar 11, 2025 • 48min
Junk Food Dangers with Robert Lustig
This week we unlock the secrets to a healthier, longer life with insights from Dr Robert Lustig as he unpacks the hidden dangers of junk food. Ever wondered how ultra-processed foods sabotage your body's natural functions? Discover how the fructose in these foods disrupts your mitochondria, leading to serious health issues like fatty liver disease and insulin resistance. Dr Lustig contrasts these effects with the benefits of whole fruits, which offer protective fibers to mitigate damage, equipping you with the knowledge to make smarter dietary choices.Join us as we challenge outdated medical beliefs and shed light on the profound connection between sugar and hypertension. By understanding the role of insulin in sodium retention and how reducing sugar intake can better manage blood pressure, you'll gain a fresh perspective on effective dietary interventions. We'll also delve into the transformation of glucose to fructose via the polyol pathway, and how this contributes to increased uric acid levels and impacts blood pressure regulation by inhibiting nitric oxide formation, based on Richard Johnson’s research.Explore the fascinating world of fats and fibers with us, as we reexamine the impacts of different lipids and introduce innovative solutions to modern dietary issues. We'll clarify misconceptions about saturated fats and highlight the benefits and risks of omega-3 and omega-6 fatty acids. Dr. Lustig explains the importance of fiber in maintaining gut health and reducing inflammation, offering practical solutions to counteract the negative impacts of ultra-processed foods. Get ready to revolutionize your understanding of diet and its profound impact on your health.Lies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...