

Health Longevity Secrets
Robert Lufkin MD
A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including longevity, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, consciousness, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe and get ready to change your life. HLS is hosted by Robert Lufkin MD, a physician/medical school professor and New York Times Bestselling author focusing on the applied science of health and longevity through lifestyle and other tools in order to cultivate consciousness, and live life to the fullest .'Envision a world of love, abundance, and generosity'.
Episodes
Mentioned books

Oct 14, 2025 • 43min
How to Fast Without Fasting
What if you could enjoy all the powerful health benefits of fasting without actually going hungry? Dr. Chris Rhodes, a biochemist with a PhD from UC Davis, has discovered a revolutionary approach that might make this possible.During this fascinating conversation, Dr. Rhodes explains how fasting triggers a remarkable survival response in our cells. After about 24 hours without food, our bodies deplete glycogen stores and enter "true fasting metabolism," activating anti-inflammatory pathways, cellular cleanup mechanisms, and metabolic efficiency programs that can extend lifespan in virtually every organism studied.The breakthrough came when Dr. Rhodes identified four specific metabolites that appear in human blood during a 36-hour fast. When combined and given to C. elegans worms, these compounds extended their lifespan by a staggering 96% - essentially doubling how long they lived.This led to the creation of Mimio Health, a company developing supplements that recreate the molecular environment of fasting. Clinical studies show these supplements can maintain an anti-inflammatory state and cardioprotective benefits even while eating regular meals. Even more remarkably, eight weeks of supplementation reduced biological age by 2.5 years, increased free testosterone by 50%, and improved cholesterol profiles and glucose regulation. I am an advisor to Mimio Health, but I only work with companies that are based on solid science with a strong potential to help humanity.Throughout our conversation, Dr. Rhodes offers thought-provoking insights about how modern eating patterns create chronic inflammation and how our bodies evolved with natural fasting cycles. He argues that constant eating without fasting windows may actually be the unnatural state for human metabolism - not the other way around.Whether you're interested in longevity, metabolic health, or simply understanding how our bodies respond to food, this episode offers a compelling look at cutting-edge nutritional biochemistry that could change how we approach health optimization. Ready to discover how your body might already possess the blueprint for extraordinary health and longevity? Listen now and learn how to activate it.Mimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Oct 7, 2025 • 37min
Will My Shirt Make Me Healthy?
What if the clothes you wear and the sheets you sleep on could actively improve your health without you doing a thing? In this fascinating conversation, Seth Casden introduces us to a truly passive biohacking tool that's hiding in plain sight.Technology transforms ordinary fabrics into wellness tools by embedding them with micron-sized minerals that capture body heat and convert it into beneficial infrared light. This light penetrates the skin and increases local circulation, delivering more oxygen to cells and tissues. The beauty lies in its simplicity—no additional effort required, no lifestyle changes needed."We're converting heat energy into light energy," Casden explains, describing how the minerals in these fabrics absorb the 100+ watts of heat constantly emitting from our bodies and return it as infrared light. Clinical studies show this process increases tissue oxygenation by about 8% after just 90 minutes of wear.Unlike many wellness technologies that require dedicated time or effort, the fabric works invisibly throughout your day in clothing and bedding. Whether you're exercising, working, or sleeping, the technology continuously improves circulation—the fundamental mechanism behind numerous health benefits from enhanced recovery to better temperature regulation.For athletes, the technology offers particular advantages. "You wear it while competing and then after the race to recover as fast as you can," Casden shares from his own experience as a triathlete. Elite sports teams, Olympic athletes, and figures like Tom Brady have already embraced the technology for its performance benefits.Ready to try this effortless biohack? Casden recommends starting with either socks (if you're on your feet all day) or pillows (to potentially enhance sleep quality and brain health). With partners including Under Armour, KT Tape, and various bedding companies, Celliant products are increasingly accessible to anyone looking to optimize their wellness without adding complexity to their lives.Curious about this technology that works while you simply live your life? Listen now and discover why improved circulation might be the simplest path to better performance, faster recovery, and enhanced wellbeing.https://celliant.com/. https://shopcelliant.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Sep 30, 2025 • 49min
Sex, Power, Suicide, and Mitochondria with Dr Natalie Yivgi-Ohana
What if the secret to treating age-related diseases and extending healthy lifespan lies within tiny cellular structures that evolved from ancient bacteria? In this mind-expanding conversation, biochemist Dr. Natalie Yivgi-Ohana reveals how mitochondria—far more than mere cellular powerhouses—control everything from hormone production to programmed cell death.Dr. Yivgi-Ohana, founder of Minovia Therapeutics, takes us on a fascinating journey through mitochondrial science, explaining how these organelles became integrated into our cells over evolutionary history. "Mitochondria used to be bacteria that entered into the cell and formed this symbiosis," she explains, describing how this evolutionary leap enabled life to thrive in oxygen-rich environments. This bacterial heritage gives mitochondria unique properties, including their own DNA separate from our nuclear genome, which makes them both vulnerable to damage and potentially replaceable.The revolutionary approach Minovia has pioneered involves harvesting a patient's own stem cells, enriching them with young, healthy mitochondria from donor sources like placentas, and returning these energized cells to the patient. Unlike direct mitochondrial infusions, which pose risks of immune rejection, this method has shown remarkable safety and efficacy in clinical trials for both rare pediatric diseases and age-related conditions. "Seeing a child six and a half years old in a baby stroller and then two months later he's running in a shopping mall—it's unbelievable to see the impact," Dr. Yivgi-Ohana shares.Perhaps most surprising is the current lack of clinical testing for mitochondrial function, despite its crucial role in health. "The strongest signal for health is how well mitochondria are doing," Dr. Yivgi-Ohana emphasizes, predicting that within a decade, mitochondrial function testing will become as routine as checking hemoglobin levels. This could transform preventive medicine by identifying mitochondrial dysfunction before symptoms appear.Explore this frontier of cellular medicine that targets both mitochondrial and immune dysfunction—two major hallmarks of aging—simultaneously. Could rejuvenating our cellular batteries be the key to extending healthy lifespan? Listen now to discover how mitochondrial science is revolutionizing our understanding of aging and disease.https://minoviatx.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Sep 23, 2025 • 48min
Does Mouthwash Cause Hypertension? with Dr Nathan Bryan
Dr. Nathan Bryan, a researcher and physiologist specializing in nitric oxide, delves into the critical roles this molecule plays in circulation and vascular health. He reveals startling effects of mouthwash on nitric oxide production, linking it to increased blood pressure. The conversation also highlights the dangers of proton pump inhibitors, which can elevate heart disease risks. Bryan explains how optimizing nitric oxide can enhance erectile dysfunction medications and shares practical tips for boosting nitric oxide naturally through lifestyle changes.

Sep 16, 2025 • 47min
Stop Overdosing Ozempic! with Dr Tyna Moore
GLP-1 agonists are transforming medicine in ways few could have predicted. In this captivating conversation, naturopathic physician Dr. Tina Moore challenges the conventional narrative around these medications, revealing their potential beyond weight loss and diabetes management.When Dr. Tina first began researching GLP-1s, she discovered a wealth of overlooked studies showing profound effects on inflammation, autoimmunity, and regenerative healing. Despite facing significant pushback from colleagues who expected a naturopathic doctor to reject pharmaceutical interventions, she couldn't ignore the compelling evidence. What she found most remarkable was how these peptides—which naturally occur in our bodies—could address multiple health issues simultaneously through their "pleiotropic" effects.The conversation ventures into territory rarely discussed in mainstream medical circles: how lower, personalized doses might provide optimal benefits while minimizing side effects. Dr. Tina shares striking clinical observations, including her own experience with Hashimoto's thyroiditis improving dramatically on a micro-dose regimen. Patients report unexpected improvements in conditions ranging from rheumatoid arthritis to depression to addictive behaviors—benefits that appear independent of weight loss.Most fascinating is Dr. Tina's perspective on dosing strategy. While conventional protocols typically start higher and escalate quickly, this approach risks receptor desensitization and excessive AMPK pathway activation, potentially causing disproportionate muscle loss. She advocates for "slow and low" dosing, tailored to individual needs, working alongside comprehensive lifestyle changes.The discussion also tackles accessibility issues, comparing compounded options with brand-name medications, and speculates about future developments that might make these treatments more affordable and personalized. If you're curious about metabolic health, inflammation, or the future of medicine, this conversation offers a refreshingly nuanced perspective that cuts through polarized debates with evidence-based insights.https://www.drtyna.com/https://www.gatlan.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Sep 9, 2025 • 47min
Keto = Death? with Dr Dom D'Agostino
Ready to revolutionize your understanding of metabolism? Dr. Dominic D'Agostino takes us deep into the science of ketosis, revealing why this evolutionary metabolic state might be the missing link in our modern health crisis.The keto revolution isn't just about weight loss. As Dr. Dom explains, ketosis fundamentally changes our physiology in ways that impact every major system in our body. While our ancestors regularly shifted in and out of this fat-burning state, most modern humans never experience it—silencing what might be a powerful tool for combating today's chronic disease epidemic.What makes ketosis unique? Unlike other dietary approaches, a properly implemented ketogenic diet actually changes brain neurochemistry, reduces inflammation, and improves metabolic markers across the board. That's why it's proven effective for conditions ranging from epilepsy to diabetes, hypertension to neurodegenerative diseases. It's not a "magic bullet" but rather a "magic shotgun" addressing multiple pathways simultaneously.Perhaps most compelling is the research showing ketosis can improve metabolic flexibility, enhance cognitive function, and potentially contribute to longevity through mechanisms like reduced inflammation and improved mitochondrial health. In a world where 72% of Americans struggle with weight issues and chronic diseases continue rising, could this metabolic switch be a key to reversing these trends?Discover why research into ketogenic therapies has exploded in recent years, with hundreds of clinical trials underway exploring applications from metabolic disorders to cancer adjunctive care. ketonutrition.orgLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Sep 2, 2025 • 41min
Lasers vs Painkillers: Deep-dive into Photobiomodulation
Guest: Forrest Smith — serial founder bringing clinic-grade photobiomodulation to a safe, wearable form factor. Theme: Why dose and delivery matter more than raw wattage for red light therapy.Key takeawaysWavelengths that work: Deep red 660 nm (blood flow, NO release, shallow penetration) + 808 nm near-IR (deeper tissues/joints).Mechanisms: Hemoglobin photodissociates NO → vasodilation + better O₂ delivery; mitochondria’s cytochrome c oxidase bottleneck relieved → higher ATP output; downstream: resilience to oxidative stress.Performance & recovery: Overnight reductions in CK and CRP let athletes train sooner; UFC PI and USA Weightlifting use cases mentioned.Brains & microvessels: Near-IR protocols tied to BDNF and microvascular improvements—an emerging Alzheimer’s angle.Dosing > device hype: Class-1 lasers allow precise, reproducible dosing to deeper targets; panels/LEDs spread light too broadly and shift dose by distance (inverse-square).Safety & contraindications: Class-1 lasers are eye-safe in normal use; titanium implants OK (osseointegration may improve). Pregnancy and active cancer: regulatory contraindications despite encouraging early data.Personal protocol (example): 15 min over carotids + 15 min lower abdomen (gut) upon waking; higher-melanin skin generally needs longer time at same power.Resources & links (from interview)Kineon: kineon.io Chapter markers (approx.)00:00 Why red light now? 00:34 Mission: measurable QoL at scale 03:02 Risks of NSAIDs vs alternatives 03:34 660 nm + 808 nm explained 05:34 Newer NIR bands (905–1064 nm) 07:39 Penetration depth: red vs NIR 08:34 Photoacceptors & evolution (melanin) 10:28 Hemoglobin, NO, and O₂ delivery 12:02 Mitochondria & ATP bottleneck 14:06 Brain protection & TBI athletes 14:34 CK/CRP drops & faster training 15:55 Dosing by melanin level 17:49 Implants, pregnancy, cancer notes 21:22 Biphasic dose curve; laser classes 25:26 LEDs vs lasers; panels’ dose drift 27:50 Strongest evidence areas (wound, knee OA) 29:33 Gut–brain, BDNF, microvasc/Alzheimer’s 31:46 Forrest’s daily protocol (neck + gut) 34:00 Systemic effects; fertilLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

4 snips
Aug 26, 2025 • 48min
Cancer Isn’t Genetic: It's Real Root Causes
Leigh Erin Connealy, a renowned integrative oncologist and author of 'The Cancer Revolution,' reveals that cancer is not merely a result of genetics. She discusses how mitochondrial dysfunction, hidden toxins, and even emotional trauma can fuel cancer's growth. Discover the magic number for cellular voltage essential for healing, and learn how overlooked infections like parasites contribute to tumor development. Connealy emphasizes holistic health strategies, including daily detox, organic nutrition, and emotional well-being to prevent disease before it manifests.

Aug 19, 2025 • 43min
The Anti-Aging Molecule You're Missing for Hair Growth, Better Sleep & Immune Power
Leslie Kenny, a patient advocate who reversed lupus and rheumatoid arthritis through lifestyle changes, dives into the transformative power of spermidine. She shares how this remarkable molecule can enhance hair growth, improve sleep, and boost immune function while reducing signs of aging. Discover the difference between food-derived and synthetic spermidine and why it’s vital for health. Leslie also reveals how spermidine activates autophagy and preserves muscle mass, offering a promising path to longevity that traditional medicine overlooks.

Aug 12, 2025 • 42min
Is Rapamycin the Best Longevity Drug? with Dr Rick Cohen
Dive into the fascinating world of longevity research as we explore rapamycin, potentially the most powerful anti-aging pharmaceutical currently known. Dr. Rick Cohen, longevity physician with over 25 years of experience, reveals how this natural molecule discovered on Easter Island targets a fundamental cellular pathway called mTOR that acts as our body's metabolic switch between growth and repair.This episode is sponsored by Gatlan who makes rapamycin that we will be discussing available in their program. I am an advisor to Gatlan but I only advise companies that I believe in and would use for myself and my family. The conversation uncovers the remarkable story behind rapamycin's discovery - how it sat forgotten in a researcher's freezer for years before its life-extending properties were recognized. Dr. Rick explains that mTOR has been conserved through billions of years of evolution precisely because it's so critical to survival, sensing nutrient availability and telling cells whether to grow or repair themselves.What makes this discussion particularly valuable is Dr. Rick's practical approach to using rapamycin as a metabolic health tool rather than a miracle drug. He shares insights on proper dosing strategies, emphasizing the importance of cycling between periods of mTOR suppression and activation to mimic natural patterns our bodies evolved with. This cycling approach - perhaps taking rapamycin for a few months, then taking a month off for anabolic growth through strength training - may be key to optimizing its benefits.The breadth of rapamycin's benefits is truly remarkable - from hair regrowth and skin rejuvenation to improvements in hearing, fertility, and protection against diseases ranging from Alzheimer's to atherosclerosis. This suggests rapamycin isn't just treating symptoms but addressing a fundamental mechanism of aging itself.Ready to understand how this single pathway could influence every aspect of how we age? Listen now to discover why balancing growth and repair cycles might be the key to extending your healthspan and potentially your healthspan and potentially your lifespan.https://www.gatlan.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...