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Siim Land Podcast

#445 Longevity Supplements Ranked by Doctor Sandra Kaufmann

Mar 21, 2025
Dr. Sandra Kaufmann, an anti-aging expert, shares her unique rating system for evaluating longevity supplements. She explores fascinating topics like the benefits of astaxanthin, NAD boosters, and curcumin, discussing how they affect cellular health. The conversation highlights disappointing supplements like resveratrol and emphasizes the importance of personalized approaches to supplementation. Kaufmann also addresses essential compounds like melatonin and taurine, urging listeners to make informed choices for lasting wellness.
01:02:34

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Podcast summary created with Snipd AI

Quick takeaways

  • Dr. Sandra Kaufmann outlines seven tenets of aging, emphasizing how cellular dysfunction influences overall health and aging processes.
  • A numerical rating system for supplements assesses their effectiveness based on human evidence, highlighting ongoing research gaps in the field.

Deep dives

Understanding the Seven Tenets of Aging

Aging can be organized into seven tenets that describe various aspects of cellular dysfunction. These tenets range from DNA alterations, such as epigenetics and telomere shortening, to mitochondrial failure, which involves several interrelated processes like energy production and nutrient utilization. Additional tenets focus on pathways affecting metabolism and circadian rhythms, quality control mechanisms for cellular integrity, the immune system's decline, individual cell needs, and waste management involving glycation issues. This structured framework helps in assessing how supplements impact overall health relative to these aging factors.

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