Discover the importance of neglected biomarkers like glucose and redox status. Learn about interpreting biomarkers for personalized nutrition and diets. Explore the breakdown of glucose and energy extraction from food. Understand release valves and biomarker ratios for catabolic breakdown and respiratory chain functioning. Analyze biomarkers related to metabolism and the impact of biotin supplementation. Emphasize the importance of analyzing nutrient response and energy metabolism. Discuss redox reactions and the NAD+/NADH ratio. Explore normal ranges for ketone and lactate ratios. Discuss biomarkers for diagnosing metabolic enzyme deficiencies. Explore balancing fasting and fed state signaling for mitochondrial biogenesis. Learn about respiratory chain complexes and treatment strategies. Discover biomarkers and tests for nutritional assessment.

This podcast discusses the use of NAC as a biofilm disruptor in gut protocols and examines the potential risks of long-term NAC use on the gut's mucous layer. It explores the different compartments of bacteria in the gut microbiota and emphasizes the importance of preserving the biofilm as a protective layer. The formation of biofilms in bacteria is explored, highlighting their reliance on disulfide bonds and the beneficial aspects of biofilms. The potential effects of NAC on gut health, including its ability to disrupt biofilms and reduce mucus thickness, are discussed. Several studies are examined regarding the effects of NAC on gastrointestinal side effects, cautioning against long-term use of high doses without specific reasons. The recommended dosage of NAC and its effects on biofilm are also discussed.

Explore the discovery of unique genetic unlocks for optimal health and how to find them. Learn about rare genes and biochemistry in health transformation. Address individual energy metabolism idiosyncrasies for improved health. Understand the concept of debugging the operating system for optimization. Discuss genetic defects and metabolic pathways. Explore synergistic heterozygosity in genetic disorders. Learn about the accuracy of genetic testing services and the importance of rare disease genes. Discover the limitations of whole genome sequencing and the significance of functional tests.

Question: How can I protect against oxalates? Short Answer: Getting 300-400 mg calcium between food and supplements at each meal will minimize oxalate absorption. Maintaining postprandial urine pH in the 6.4-6.8 range by getting 3-5 grams of potassium per day from food or from organic acid salts such as potassium citrate will prevent its crystallization in the kidney. Reducing dietary oxalate will prevent any possible damage in the gut. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-blood-glucose-and-oxalate In that batch of free episodes you will also find the answer to this question:  Why Should Postprandial Glucose Be Kept Under 140 mg/dL? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the April 12, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included: What Causes Hypercholesterolemia and Does It Matter? How to Reverse Coronary Calcification? How to do a comprehensive nutritional screening How long after eating improperly cooked egg whites should I wait to take biotin? Is the extrusion process as harmful as some claim? How long can one fast before micronutrient deficiencies become an issue? Do B vitamins compete with each other for absorption? Why is thirst a symptom of diabetes? Do I agree with Peter Attia that ApoB should be driven as low as pharmacologically possible? During a fast, does the body break down muscle? How do you rest and refeed your brain? Why would someone have high RBC magnesium but low serum magnesium? GLA deficiency? Should we eat for our ethnicity? How convincing are polyphenol studies? Can coronary calcium be driven by oxalate? Citrulline for vasodilation How to reduce catabolism Rapid-fire run-through of orphaned questions from the submission contest, including a detailed look at Nadia’s thyroid numbers Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-april Access the show notes, transcript, and comments here.    

The podcast discusses the importance of keeping post-prandial blood glucose levels under 140 mg/dL to avoid negative effects on metabolism. It explores the relationship between sorbitol and plasma glucose levels, the significance of adaptation to postprandial glucose levels, and the importance of glycemic load adaptation for overall health.

This podcast discusses the historical synthesis of Methylene Blue in medicine, its role in rerouting electrons and therapeutic applications, the effects and risks of Methylene Blue including decreased brain connectivity, and its potential benefits as a disinfectant and in treating respiratory chain disorders.

Explore the uses and effects of methylene blue, from its historical background to its potential benefits for mitochondrial health. Learn about the redox reactions and the cycling process of methylene blue. Discover the role of complexes in cellular respiration and the interplay between fat, leucine, and the electron transport chain. Understand the complexity of the respiratory chain and the impact of nutrient deficiencies on energy metabolism.

Masterjohn, podcast host, explores the relationship between copper and estrogen in this episode. They discuss how estrogen moves copper from the mother's bloodstream to the fetus during pregnancy and how it promotes intestinal copper absorption. Maintaining pregnancy-level hormones while not pregnant poses a risk of promoting too much copper absorption. Copper status should be monitored when using supplemental hormones to avoid toxicity.

This is now subscribers-only and is available here: https://chrismasterjohnphd.substack.com/p/why-would-citrate-or-malate-cause

This is now subscribers-only and can be accessed here: https://chrismasterjohnphd.substack.com/p/what-to-do-about-constipation