Mastering Nutrition

An exploration of the startle reflex and its underlying conditions, the dominant role of glycine neurotransmission in hyper-eplexia, treatment options and nutritional strategies for glycine neurotransmission disorders, factors leading to glycine loss in urine and strategies to increase glycine intake, and the therapeutic use and potential risks of glycine.

This podcast explores the role of hormones as messengers and the importance of addressing underlying biochemical issues. It discusses exceptions to the rule of hormone imbalances and the interaction between leptin, insulin, and thyroid hormone. It also examines the mechanisms behind insulin release and the influence of macronutrients and zinc. Furthermore, it delves into how amino acids and hormones regulate energy and the impact of energy abundance on fertility and health. The podcast emphasizes the need for personalized approaches to managing hormone problems.

Discover the wide-ranging benefits of biotin beyond hair and nails. Explore its impact on multiple sclerosis, fertility, and biotin deficiency. Learn about recommended dosage and potential risks of high-dose intake.

The podcast explores the harmful effects of biotin supplements, including increased muscle tension and short-term memory loss. It discusses how biotin affects energy metabolism and the balance between different steps. The case study highlights the adverse effects of biotin supplements and the significance of measuring metabolic levels. It also emphasizes monitoring lactate levels as an indicator of metabolic impairments caused by supplementation.

Question: Why Would Vitamin C cause muscle pain, joint pain, and brain fog? Short Answer: Acutely, vitamin C would likely cause these effects by generating oxalate, which could cause crystals that lead to muscle and joint pain, and could cut energy metabolism in half, leading to brain fog. This vulnerability could result from deficiencies of any of the B vitamins, any of the electrolytes, or of iron, copper, or sulfur; from diabetes, low adrenals, or hypothyroidism; or from any of the hundreds of genetic defects in energy metabolism, only one of which is glucose 6-phosphate dehydrogenase deficiency; or any one of a huge number of toxins that impair energy metabolism. Chronically, vitamin C may increase the harms of iron overload or contribute to copper deficiency. The main ways to manage these latter issues are to take vitamin C away from meals, to maintain good copper status through proper dietary intake, and to treat iron overload with phlebotomy. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin In that batch of free episodes you will also find the answer to this question: Can NAC hurt your gut health? How to Find the Root Cause of Autoimmunity? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: GLA to lower hydroxyhaemopyrrolin-2-one? When would I use the StrateGene and Genova Methylation Panel for nutritional testing? Energy metabolism as a root cause of gut issues? Nutrition for skin healing? Nutrition for hypnic jerks? Suggestions for snoring or sleep apnea? Nutrition to protect against restaurant meals? What is the cause of crusty eyes in the morning? What causes brain fog? How much oxalate should one eat each day? Should I be concerned about low alkaline phosphatase? What nutrients give tall children to short parents? Energy metabolism impairment mimicking Wilson's disease. Can taking digestive enzymes reduce our own production? Rapid-fire response to non-winners from the question contest. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Discover why a high-protein diet may lead to a biotin deficiency and the detrimental effects it can have on your body. Learn about the protein paradox, markers of biotin status, and the importance of being biochemically optimized for brain health. Explore the effects of toxic load on brain health, biotin-rich foods, and the reliability of biotin and food databases.

The use of high-dose biotin supplements has increased almost 30-fold over the last twenty years for such problems as diabetes, smell and taste disorders, disorders of the hair, skin, and nails, and multiple sclerosis. Studies show it can improve diabetes, and case reports show it can miraculously recover lost smell and taste even when smell and taste were lost as a result of surgery or the side effects of medications or other supplements. Yet, some studies show multiple sclerosis gets worse on high-dose biotin. I personally developed clumsiness, short-term memory loss, and a short temper on high-dose biotin. Some studies show it makes blood sugar get better, yet it made my blood sugar get worse. High-dose biotin can also cause wide-ranging errors in lab tests with the potential to mask recent heart attacks, pregnancies, or allergies; to misdiagnose thyroid conditions; to give false signals about the presence or progression of tumors; to falsely raise vitamin D, B12, and folate levels; to falsely alter many hormone levels; to generate false positives for HIV and hepatitis; and to lead to unnecessary surgery and possibly even death as a result of diagnostic errors. Most people need more biotin than they get. Some one in 30 people need high-dose biotin for genetic reasons, and most other people should be getting lower doses. So, how do we know how much we need, and whether we are getting the right amount? When is the right time to break open the bottle of the ten-milligram capsules? This article covers the safety and efficacy of high-dose biotin for all the conditions documented in the literature, its potential anti-fertility effects, and how and when to balance it with other vitamins. This podcast is a preview of a podcast reserved for Masterpass members. Get permanent access to the video and podcast, and get the written and fully referenced article, here: https://chrismasterjohnphd.substack.com/p/when-high-dose-biotin-is-truly-needed Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Discover the importance of neglected biomarkers like glucose and redox status. Learn about interpreting biomarkers for personalized nutrition and diets. Explore the breakdown of glucose and energy extraction from food. Understand release valves and biomarker ratios for catabolic breakdown and respiratory chain functioning. Analyze biomarkers related to metabolism and the impact of biotin supplementation. Emphasize the importance of analyzing nutrient response and energy metabolism. Discuss redox reactions and the NAD+/NADH ratio. Explore normal ranges for ketone and lactate ratios. Discuss biomarkers for diagnosing metabolic enzyme deficiencies. Explore balancing fasting and fed state signaling for mitochondrial biogenesis. Learn about respiratory chain complexes and treatment strategies. Discover biomarkers and tests for nutritional assessment.

This podcast discusses the use of NAC as a biofilm disruptor in gut protocols and examines the potential risks of long-term NAC use on the gut's mucous layer. It explores the different compartments of bacteria in the gut microbiota and emphasizes the importance of preserving the biofilm as a protective layer. The formation of biofilms in bacteria is explored, highlighting their reliance on disulfide bonds and the beneficial aspects of biofilms. The potential effects of NAC on gut health, including its ability to disrupt biofilms and reduce mucus thickness, are discussed. Several studies are examined regarding the effects of NAC on gastrointestinal side effects, cautioning against long-term use of high doses without specific reasons. The recommended dosage of NAC and its effects on biofilm are also discussed.

Explore the discovery of unique genetic unlocks for optimal health and how to find them. Learn about rare genes and biochemistry in health transformation. Address individual energy metabolism idiosyncrasies for improved health. Understand the concept of debugging the operating system for optimization. Discuss genetic defects and metabolic pathways. Explore synergistic heterozygosity in genetic disorders. Learn about the accuracy of genetic testing services and the importance of rare disease genes. Discover the limitations of whole genome sequencing and the significance of functional tests.