
Mastering Nutrition
What is the relationship between copper and estrogen? | Masterjohn Q&A Files #322
Aug 28, 2023
Masterjohn, podcast host, explores the relationship between copper and estrogen in this episode. They discuss how estrogen moves copper from the mother's bloodstream to the fetus during pregnancy and how it promotes intestinal copper absorption. Maintaining pregnancy-level hormones while not pregnant poses a risk of promoting too much copper absorption. Copper status should be monitored when using supplemental hormones to avoid toxicity.
12:08
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Quick takeaways
- Estrogen moves copper from the mother's bloodstream to the fetus during pregnancy, while estrogen and progesterone work together to promote intestinal copper absorption.
- Hormonal imbalances caused by birth control or hormone replacement therapies can lead to copper toxicity and contribute to cyclical histamine intolerance and postpartum symptoms.
Deep dives
The relationship between copper and estrogen
Women of reproductive age have higher plasma copper and sero-loplasmid. Hormonal contraceptives increase copper levels, independent of copper content. Estrogen and insulin stimulate placenta expression of transporters that direct copper to the fetus. Copper absorption from food is higher in women of reproductive age compared to men. Estrogen interacts with progesterone to determine copper absorption effect.
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