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Mastering Nutrition

Why Should Postprandial Glucose Be Kept Under 140 mg/dL? | Masterjohn Q&A Files #323

Sep 11, 2023
The podcast discusses the importance of keeping post-prandial blood glucose levels under 140 mg/dL to avoid negative effects on metabolism. It explores the relationship between sorbitol and plasma glucose levels, the significance of adaptation to postprandial glucose levels, and the importance of glycemic load adaptation for overall health.
10:21
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Podcast summary created with Snipd AI

Quick takeaways

  • Postprandial blood glucose above 140 mg/dL triggers the polyol pathway, compromising antioxidant status and recycling of important vitamins.
  • Reaching blood glucose levels above 140 mg/dL occasionally should not cause concern, but repeated spikes with consistent consumption may indicate suboptimal metabolic state.

Deep dives

The Importance of Keeping Post-Prandial Blood Glucose below 140 mg/dL

Confusion about the significance of post-prandial blood glucose levels above 140 mg/dL is addressed. The speaker explains that exceeding this threshold is associated with the activation of the polyol pathway, which negatively affects the supply of NADPH and reduces the recycling of glutathione and vitamin C. While going above 140 mg/dL does not necessarily cause metabolic deterioration, it indicates the beginning of a suboptimal metabolic state. Evidence from studies shows that a linear relation between plasma glucose and sorbitol levels exists up to 6 millimolar, but a gap occurs between 6-8 millimolar, corresponding roughly to the 140 mg/dL mark. The speaker emphasizes that maintaining sorbitol levels within the normal range is important for optimal health.

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