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Mastering Nutrition
Methylene Blue in 10 Minutes
Sep 2, 2023
This podcast discusses the historical synthesis of Methylene Blue in medicine, its role in rerouting electrons and therapeutic applications, the effects and risks of Methylene Blue including decreased brain connectivity, and its potential benefits as a disinfectant and in treating respiratory chain disorders.
09:57
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Quick takeaways
- Methylene blue has versatile applications, including treating methemoglobinemia, Alzheimer's disease, cyanide/hydrogen sulfide poisoning, and enhancing memory.
- Methylene blue acts as an MAOI, providing antidepressant and anti-anxiety effects, but has potential risks of serotonin toxicity, hypertension, and dependence.
Deep dives
Methylene Blue: A Synthetic Drug and Redox Reactive Dye
Methylene Blue, first synthesized in 1876, became the first synthetic drug through successful malaria treatment in 1891. Its redox reactive properties are demonstrated in the blue bottle experiment, where it can turn a mixture blue and then colorless. These properties make methylene blue effective in catalyzing phototherapy for superficial infections and tumors. Furthermore, it has the ability to oxidize or reduce different targets, allowing it to rewire the mitochondrial respiratory chain.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode