The Optispan Podcast with Matt Kaeberlein

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Meet the founders (Ivan Morgunov, Anna Vakhrusheva) of Unlimited Bio, a biotech company developing gene therapies in special economic zones, operating outside of traditional FDA regulation. This episode explores their model, the science behind their therapies targeting the extracellular matrix, and the future of accessible anti-aging treatments.0:00 - The Mission: Fighting Overregulation in Longevity9:31 - The Science: Why the Extracellular Matrix is Key30:16 - The Offshore Model: How It Works & The Controversies54:04 - Their First Therapy: VEGF Gene Therapy Explained55:51 - The Quality Debate: GMP vs. A New Approach1:24:16 - The Future Pipeline: Follistatin, Klotho & Combination Therapies1:48:27 - The Vision: A New Regulatory System for the USProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Dr. Matt Kaeberlein answers burning questions about testosterone therapy and the longevity drug rapamycin. He explains his own injection protocol and offers insights on its use for women. The discussion highlights the pitfalls of excessive supplement regimens and debunks common diet myths, including time-restricted eating. Matt also clarifies the differences between DEXA scans and their importance for body composition. Stick around for entertaining tales from his Ireland trip featuring Guinness and whiskey!

Join longevity pioneers Aubrey de Grey, a biomedical gerontologist focused on rejuvenation strategies, and Brian Kennedy, an expert in aging biology. They share fascinating insights on achieving longevity escape velocity, debating the benefits of damage-repair versus growth-slowing methods. Aubrey discusses his groundbreaking mouse studies and the search for effective combination therapies, while both express cautious optimism about emerging clinical applications. They emphasize the importance of transparency in experimental treatments and the future potential of biological age measurement.

A recent longevity conference faced a shocking incident where attendees were hospitalized after peptide injections. The discussion reveals a concerning mix of genuine science and pseudoscience in the health sector. Experts emphasize the necessity of discernment and skepticism towards unverified treatments. They explore the realities of libertarian healthcare approaches and the risks involved. The podcast also delves into the bizarre decisions some educated individuals make in the name of wellness, questioning the credibility of emerging therapies.

Kevin White, a medical clinician specializing in hormone replacement and men's health, joins Matt to explore the journey of testosterone therapy. They discuss the initial signs of low testosterone, the mistakes made when starting treatment, and the importance of understanding lab results beyond total testosterone. Kevin provides insights on managing side effects, the debate between oral and injectable forms, and the link between testosterone levels and overall health. The conversation also tackles common myths and emphasizes the role of lifestyle changes alongside therapy.

Jan Gruber, a physicist with a revolutionary take on aging, explores how it is a gradual loss of resilience against random events. He challenges traditional views on biological clocks and discusses the intricate interplay between genetics, lifestyle, and stochastic damage. The conversation dives into innovative methods for measuring biological age and potential lifespan interventions. Gruber also highlights the surprising benefits of shifting health strategies, offering fresh insights into the science of longevity that could reshape our understanding of aging.

Dr. Nicki Byrne and Dr. Kevin White, both practicing physicians at Optispan with a focus on preventative medicine, explore the four pillars of lifelong health: eat, move, sleep, and connect. They delve into the significance of real-time glucose monitoring for better dietary choices and emphasize the importance of consistent exercise and sleep routines. The doctors discuss critical blood tests that matter for personalized health strategies, tackle hormonal health myths, and even touch on stress management in promoting overall wellness.

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity expert Dr. Matt Kaeberlein breaks down three new scientific studies on the popular anti-aging drug rapamycin and the supplement taurine. Discover which research shows real promise for conditions like chronic fatigue and which studies are being overhyped in the longevity community.0:00 - Intro: 3 Hot Longevity Papers0:29 - Rapamycin for Alzheimer's: A Flawed Study?17:53 - A Breakthrough for Chronic Fatigue? (New Rapamycin Study)23:29 - The Promising Results: How Rapamycin Helped34:44 - Taurine: Does It Really Affect Aging?39:20 - The Big Miss: What the Taurine Study Didn't Do41:13 - Final Take: What This Science Actually Means for YouProduction: Tara Mei, Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein tackles your burning questions on testosterone therapy, trending supplements like astaxanthin and C15, hyperbaric oxygen, and more. Get science-backed insights and learn what truly matters for starting your health and longevity journey.0:00 - Intro: Ask Matt Anything!0:42 - Testosterone Therapy: My Personal Journey3:12 - Hormone Health: What to Measure & Why It's Key8:24 - High APOB/LDL: Should You Worry?14:32 - Plasma Exchange vs. Donation: What's the Difference?18:55 - Hyperbaric Oxygen: Longevity Tool or Hype?26:18 - Astaxanthin & C15: "Miracle" Longevity Supplements?45:37 - Why Don't Scientists Give Straight Answers?Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Dive into the world of health trends as experts dissect controversial views on supplements, MRIs, and protein intake. Discover the murky waters of the supplement industry and the risks of over-medicalization. Unpack the realities of protein consumption and challenge the one gram per pound myth. Explore the hype surrounding rapamycin and the importance of evidence over anecdotes. Finally, weigh the benefits and drawbacks of total body MRIs in preventive healthcare, bringing clarity to modern health decisions.