The Optispan Podcast with Matt Kaeberlein

My Review of Peter Attia’s AMA: What I Agree & Disagree With | 91

Jan 2, 2025

Dive into the intriguing world of health and longevity with gripping insights on grip strength as a predictor of overall health. Discover travel-friendly exercise strategies and the importance of biomarkers like ApoB and OGTT. Learn about the transformative potential of GLP-1 agonists and the promise of Klotho research. Explore the impact of AI on personalized healthcare and the skepticism surrounding direct-to-consumer biological age tests. Plus, uncover essential foundational exercises for fitness at any age!

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INSIGHT

Grip Strength Is A Proxy Not A Panacea

Grip strength correlates with longevity but is likely a proxy for overall muscle function rather than a direct causal factor.
Regular resistance training increases grip strength indirectly, so specific gripper training is probably unnecessary.

ADVICE

Keep Resistance Training Simple While Traveling

When traveling, prioritize staying where a minimal gym exists and do resistance training every other day if possible.
Use bodyweight exercises in a hotel room and walk frequently to maintain fitness on the road.

ADVICE

Measure Systems Not Single Numbers

Assess health by systems: body composition (DEXA), hormones, metabolic health (OGTT/CGM), lipids, and functional strength measures.
Prefer OGTT for insulin and glucose insight, or use CGM at home if you know how to interpret the data.

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Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt shares his thoughts on Peter Attia's AMA , exploring areas of agreement and differing perspectives on health and longevity. Topics include the significance of grip strength, biomarkers for health assessment, exercise strategies while traveling, and advancements in longevity research like Klotho and GLP-1 agonists. Matt also discusses the role of AI in healthcare and addresses concerns about direct-to-consumer biological age tests. The episode concludes with a discussion of foundational exercises and the interconnected nature of aging and health.Timestamps:0:00 Introduction1:24 Why grip strength matters for longevity5:50 Exercise strategies while traveling9:34 Most important biomarkers for health12:58 Advancements in longevity research: GLP-1 agonists and Klotho20:05 The role of AI in healthcare and longevity25:15 Debunking myths about biological age tests30:45 Top 10 foundational exercises for fitness36:13 Concluding thoughts and reflections on Peter Attia’s AMAProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!