The Optispan Podcast with Matt Kaeberlein

Dr. Brad Stanfield, a primary care physician and YouTube communicator from New Zealand, shares his passion for longevity research. He reveals his bold decision to remortgage his house to fund a rapamycin clinical trial. The discussion dives into the importance of evidence-based medicine and the complexities of supplements like vitamin D. Stanfield critiques biological age clocks and emphasizes the difference between preventive care in New Zealand and the U.S., while urging a focus on rigorous, patient-centered clinical trials for better insights into aging.

Matt dives into the alarming issue of deepfake videos impersonating reputable figures in health. He uncovers the misleading claims made in these videos about common health items like green tea and coffee. The dangers of pseudoscience are highlighted, showing how misinformation can harm real health efforts. Listeners learn practical tips to avoid falling for longevity scams, such as verifying expert credentials and resisting emotional manipulation. The conversation stresses the importance of relying on trustworthy sources to navigate health information.

Joel Jamison, a coach and fitness expert, shares his personal heart-health journey, including a shocking calcium score that revealed significant health risks. The discussion dives into the nuances of heart rate variability (HRV), contrasting the needs for athletes versus those focused on longevity. Joel also emphasizes the importance of advanced imaging over standard tests for individuals with family histories of heart disease. Plus, he challenges the accuracy of wearable tech in measuring vital health metrics, urging early screening for those at risk.

Dr. Jon Berner, a psychiatrist and clinician-scientist specializing in lithium and rapamycin, uncovers the hidden potential of these compounds in health. He discusses lithium's emerging role in mitigating Alzheimer's risk and the importance of individualized dosing strategies. The conversation shifts to rapamycin and its promising application for Chronic Fatigue Syndrome, delving into its connection to inflammation and potential reproductive benefits. Dr. Berner advocates for personalized treatment and explores innovative dosing methodologies that could reshape therapeutic approaches.

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join me for an in-depth conversation with Dr. Alex and Dr. Jan from the YEARS Healthspan Clinic in Berlin. They pull back the curtain on what a truly evidence-based, scientific approach to longevity medicine looks like, moving beyond the hype and "snake oil" to focus on rigorous diagnostics, personalized interventions, and the critical collection of high-quality data.In this episode, they delve into the comprehensive 6+ hour diagnostic workup I am about to undergo, discuss the hierarchy of interventions (from lifestyle as the foundation to the careful use of pharmaceuticals), and debate the role of supplements, peptides, and more experimental therapies. This is a masterclass in the practical application of healthspan medicine from leading clinicians in the field.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps:00:00 – Trailer01:12 – Introduction02:19 – Inside the 6-Hour Health Assessment05:00 – Full-Body MRI & Advanced Testing11:57 – Biological Age Tests & Organ-Specific Clocks17:10 – "Scientific Healthspan" vs. Longevity Medicine25:50 – Reversing Type 2 Diabetes: A Real-World Case31:42 – Supplements: Separating Facts from Fads43:20 – Rapamycin, GLP-1s & Metformin: What's Proven?54:00 – Muscle Loss, Brain Health & Alzheimer's Prevention01:05:11 – Stem Cells, Exosomes & Peptides: Hype or Hope?01:12:57 – No Shortcuts: The Need for Clinical Trials01:17:47 – Preventive Cardiology & Lipid Management01:26:52 – Hormone Therapy: Men, Women & Misconceptions01:33:12 – The Longevity Field's Biggest Problem01:39:05 – "Dr. ChatGPT" & The Self-Diagnosis Dilemma01:43:14 – Why Healthcare Must Change Now01:45:26 – Closing ThoughtsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Dr. Brad Younggren, an emergency physician and CEO at Circulate, shares his journey from combat to longevity science. They dive into the innovative Therapeutic Plasma Exchange (TPE), likening it to an 'oil change for your blood.' Discover how TPE may reduce biological age by 2.6 years, tackling toxins like microplastics and chronic diseases. Dr. Younggren discusses clinical trial insights, the science of parabiosis, and the impressive results observed, while sharing patient stories, including improvements in long COVID symptoms.

Explore the intriguing contrasts between high-stakes investor gatherings and academic conferences in the longevity field. Discover the ethical dilemmas surrounding biological age clocks and hear a hilarious MRI tale from Berlin. Dive into insights about the divide between genuine science and snake oil remedies, and the challenges of translating geroscience into practical therapies. From promising biomarkers to the impact of celebrity culture, the conversation spotlights the complex landscape of longevity and health optimization.

Dr. Cory, a systems biologist at the Institute for Systems Biology and co-founder of Fulcrum, explores innovative perspectives on Alzheimer's. He argues that it's not just about amyloid plaques, but rather a flawed debris management system in the brain, particularly concerning cholesterol. Discussing the roles of genes like ApoE4 and the impact of lifestyle factors, he sheds light on why current drugs often fail. Dr. Cory also highlights practical prevention tips, emphasizing sleep, diet, and personalized lifestyle choices to combat Alzheimer's.

In this enlightening discussion, Kayla Barnes, a longevity clinician and biohacker, shares her journey from a conventional lifestyle to health optimization. She highlights how toxin reduction and consistent practices, like sauna use, can transform health. Kayla explores female-specific longevity issues, emphasizing the impact of ovarian aging and the need for more research. She dives into cutting-edge therapies such as therapeutic plasma exchange and hyperbaric oxygen, revealing their potential benefits while stressing the importance of evidence-based protocols.

Ryan Ware, a medical doctor and co-founder of MitoHealth, dives into the intersection of AI and medicine. He and Matt Kaeberlein discuss how tools like ChatGPT can interpret blood tests faster than traditional methods. The conversation highlights the pitfalls of supplements, emphasizes the need for evidence-based health decisions, and critiques the wellness industry’s blind spots. They also explore the evolving role of physicians in an AI-driven era and the importance of reliable diagnostics for proactive health management.