The Optispan Podcast with Matt Kaeberlein

In this intriguing discussion, Dr. Ben Blue, CEO of Ora Biomedical and co-founder of the WormBot platform, shares insights into groundbreaking longevity research. He reveals how the Million Molecule Challenge aims to transform drug discovery for aging by identifying powerful new molecules. Notably, Dr. Blue discusses omipalisib, a molecule outperforming rapamycin, and the team's strategic pivot towards radiation resilience for space applications. They explore the significance of a data-driven approach and unexpected findings from their high-throughput screenings.

Happy thanksgiving from the Optispan Team!

Dr. Andrew Steele, a longevity scientist and author, discusses the urgent need to address aging as humanity's greatest challenge. He uncovers that two-thirds of all deaths stem from aging and explores groundbreaking science that could extend healthy lifespan. Topics include CRISPR gene therapies, the ethical considerations of radical life extension, and practical lifestyle changes for longevity. Steele also delves into the potential of AI in aging research, emphasizing the societal benefits of adding decades of vitality to human life.

Creatine is often dubbed a 'cognitive super-drug,' but the hype around mega-dosing is misleading. The hosts critically evaluate various claims from health influencers, debunking the idea that 20 grams a day is beneficial. They explore the actual effects on brain health, resistance training, and potential side effects. Insights on how to judge health claims and a simple, effective dosing protocol are shared. Ultimately, they recommend a modest daily intake of 5 grams while encouraging listeners to prioritize sleep and training.

In this enlightening discussion, Jamie Justice, Executive Vice President for Health and Director of the $101M XPRIZE Healthspan, dives into the ambitious goals of this global competition aimed at extending human healthspan. He shares insights on the challenges faced by past trials like TAME and the importance of real-world applications for the prize winners. Jamie discusses key healthspan pillars, ethical considerations in clinical trials, and the potential for innovative solutions like public health initiatives to win. Expect a mix of science, ambition, and a dash of the unusual!

Dr. Brad Stanfield, a primary care physician and YouTube communicator from New Zealand, shares his passion for longevity research. He reveals his bold decision to remortgage his house to fund a rapamycin clinical trial. The discussion dives into the importance of evidence-based medicine and the complexities of supplements like vitamin D. Stanfield critiques biological age clocks and emphasizes the difference between preventive care in New Zealand and the U.S., while urging a focus on rigorous, patient-centered clinical trials for better insights into aging.

Matt dives into the alarming issue of deepfake videos impersonating reputable figures in health. He uncovers the misleading claims made in these videos about common health items like green tea and coffee. The dangers of pseudoscience are highlighted, showing how misinformation can harm real health efforts. Listeners learn practical tips to avoid falling for longevity scams, such as verifying expert credentials and resisting emotional manipulation. The conversation stresses the importance of relying on trustworthy sources to navigate health information.

Joel Jamison, a coach and fitness expert, shares his personal heart-health journey, including a shocking calcium score that revealed significant health risks. The discussion dives into the nuances of heart rate variability (HRV), contrasting the needs for athletes versus those focused on longevity. Joel also emphasizes the importance of advanced imaging over standard tests for individuals with family histories of heart disease. Plus, he challenges the accuracy of wearable tech in measuring vital health metrics, urging early screening for those at risk.

Dr. Jon Berner, a psychiatrist and clinician-scientist specializing in lithium and rapamycin, uncovers the hidden potential of these compounds in health. He discusses lithium's emerging role in mitigating Alzheimer's risk and the importance of individualized dosing strategies. The conversation shifts to rapamycin and its promising application for Chronic Fatigue Syndrome, delving into its connection to inflammation and potential reproductive benefits. Dr. Berner advocates for personalized treatment and explores innovative dosing methodologies that could reshape therapeutic approaches.

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join me for an in-depth conversation with Dr. Alex and Dr. Jan from the YEARS Healthspan Clinic in Berlin. They pull back the curtain on what a truly evidence-based, scientific approach to longevity medicine looks like, moving beyond the hype and "snake oil" to focus on rigorous diagnostics, personalized interventions, and the critical collection of high-quality data.In this episode, they delve into the comprehensive 6+ hour diagnostic workup I am about to undergo, discuss the hierarchy of interventions (from lifestyle as the foundation to the careful use of pharmaceuticals), and debate the role of supplements, peptides, and more experimental therapies. This is a masterclass in the practical application of healthspan medicine from leading clinicians in the field.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps:00:00 – Trailer01:12 – Introduction02:19 – Inside the 6-Hour Health Assessment05:00 – Full-Body MRI & Advanced Testing11:57 – Biological Age Tests & Organ-Specific Clocks17:10 – "Scientific Healthspan" vs. Longevity Medicine25:50 – Reversing Type 2 Diabetes: A Real-World Case31:42 – Supplements: Separating Facts from Fads43:20 – Rapamycin, GLP-1s & Metformin: What's Proven?54:00 – Muscle Loss, Brain Health & Alzheimer's Prevention01:05:11 – Stem Cells, Exosomes & Peptides: Hype or Hope?01:12:57 – No Shortcuts: The Need for Clinical Trials01:17:47 – Preventive Cardiology & Lipid Management01:26:52 – Hormone Therapy: Men, Women & Misconceptions01:33:12 – The Longevity Field's Biggest Problem01:39:05 – "Dr. ChatGPT" & The Self-Diagnosis Dilemma01:43:14 – Why Healthcare Must Change Now01:45:26 – Closing ThoughtsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!