The Optispan Podcast with Matt Kaeberlein

Siim Land, a biohacking expert and author of The Longevity Leap, joins to discuss science-backed strategies for enhancing health span. He delves into the critical distinctions between healthspan and lifespan, emphasizing the importance of quality over mere longevity. The conversation tackles navigating misinformation in the health space, particularly about supplements and lifestyle choices. Siim shares insights from his creatine experiment and highlights essential biomarkers for health monitoring, while advocating for a balanced approach to diet, exercise, and social connections.

Discover a groundbreaking approach to aging that emphasizes health over mere longevity. The discussion dives into Healthspan Medicine, advocating for proactive strategies to enhance well-being as we age. Collaboration among healthcare professionals is key, alongside personalized lifestyle choices and advanced diagnostics. It’s all about living better, not just longer!

Dr. Marcus Ranney, a leading longevity physician from India, and Dr. Brian Kennedy, a biochemistry professor at the National University of Singapore, share insights on advancing longevity science. They discuss India's unique health challenges despite a vegetarian diet and the role of AI in transforming healthcare. Topics include groundbreaking research on stem cell therapy, the importance of hormone replacement, and the effectiveness of supplements like NMN and NAD+. The conversation emphasizes personalized medicine and innovative health monitoring solutions for better aging.

Dr. Christin Glorioso, founder of NeuroAge Therapeutics, dives into the cutting-edge landscape of brain aging and Alzheimer’s prevention. Discover how innovative tests predict Alzheimer’s risk decades ahead, combining genetic insights with lifestyle choices. Glorioso discusses the power of diet, exercise, and sleep on cognitive health, alongside the latest advancements in medications like GLP-1 agonists. Plus, learn about the fascinating role of MRI scans and neural games in assessing brain health, making a compelling case for the future of cognitive well-being.

Dr. Mary Pardee, co-founder and CEO of DeepMind, shares her expertise on gut health and the microbiome. She delves into the complexities of IBS, discussing effective treatment options through diet and lifestyle changes. The conversation debunks myths surrounding microbiome testing and evaluates the reliability of direct-to-consumer tests. Mary emphasizes the importance of probiotics and sheds light on the supplement market, revealing what's genuinely beneficial for gut health. This insightful talk is packed with science-backed tips for long-term wellness!

Dive into the world of biological age tests and discover why many may not be as reliable as claimed. Explore the significant issues surrounding their accuracy and lack of regulatory validation. Learn about the real biomarkers that can enhance longevity and well-being instead of relying on misleading tests. This insightful discussion helps you rethink whether spending money on these tests is truly worthwhile.

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We discuss the costs, the role of insurance, advanced diagnostics, and the future of AI in concierge medicine.0:00 - Intro & Concierge Medicine Overview3:15 - How Concierge Medicine Differs from Primary Care9:40 - Benefits of Personalized Doctor Access15:20 - Costs, Insurance, & Payment Options21:05 - Longevity & Proactive Health Strategies28:35 - Advanced Testing & Diagnostics in Concierge Care35:50 - AI & Technology in Concierge Medicine42:10 - How to Find a Good Concierge DoctorProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanThomas DeLauer & I (Dr. Matt Kaeberlein) discusses his evolving perspectives on nutrition, exercise, and health optimization. Thomas shares how his views on insulin, low-carb diets, and fructose have shifted, his approach to training for strength and longevity, and the importance of sleep, emotional well-being, and recovery. Delauer also touches on peptides, supplements, and wearable tech, providing valuable takeaways for those looking to improve their performance, body composition, and overall health.0:00 - Introduction & Thomas DeLauer’s evolving views2:10 - The challenge of simplifying health content4:57 - Shifting perspectives on nutrition & health goals7:55 - Low-carb lifestyle & insulin reconsidered12:49 - A day in the life: Diet, fasting & protein intake19:04 - Strength training, cardio & hybrid workouts25:45 - Sleep optimization & recovery strategies30:11 - Emotional health, connection & mindfulness36:02 - Peptides, supplements & risk vs. rewardProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanI share the top health and longevity strategies that have transformed my energy, fitness, and well-being at 54 - From hormone optimization (TRT) and resistance training to diet improvements, alcohol reduction, and preventative diagnostics.0:00 - Reflections on Turning 54 & Longevity Mindset1:42 - Hormone Optimization: The Biggest Game-Changer3:28 - Diet & Alcohol Reduction: Key Health Improvements4:56 - Exercise & Resistance Training for Longevity9:10 - Preventative Diagnostics & Biomarkers Matter16:46 - Relationships & Mental Well-Being in HealthProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanDr. Greg Fahy discusses his groundbreaking research on thymus regeneration, immune system rejuvenation, and the role of growth hormone, DHEA, and metformin in reversing aging-related immune decline. He explains the TRIM protocol, the impact of thymic involution on longevity, and the potential for improving vaccine response and overall health. This conversation explores immune function, senescent cell clearance, and epigenetic aging clocks.0:00 - Introduction & Guest Introduction2:05 - The Origins of the TRIM Protocol6:30 - Growth Hormone & Thymus Regeneration in Rats12:40 - Growth Hormone, Insulin Resistance & DHEA20:10 - Why Thymus Regeneration Matters for Longevity27:50 - Thymic Involution & Its Role in Aging35:45 - Measuring Thymic Function & Immune Rejuvenation42:15 - Rapamycin, Thymus, and Immune System Enhancement50:20 - Human Trials: Thymus Regeneration & Exercise Performance1:03:00 - The Future of Anti-Aging & Immune RestorationProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!