The Optispan Podcast with Matt Kaeberlein

Brain Aging & Alzheimer’s Prevention: The Future of Cognitive Health Testing | Dr. Christin Glorioso | 106

Mar 18, 2025
Dr. Christin Glorioso, founder of NeuroAge Therapeutics, dives into the cutting-edge landscape of brain aging and Alzheimer’s prevention. Discover how innovative tests predict Alzheimer’s risk decades ahead, combining genetic insights with lifestyle choices. Glorioso discusses the power of diet, exercise, and sleep on cognitive health, alongside the latest advancements in medications like GLP-1 agonists. Plus, learn about the fascinating role of MRI scans and neural games in assessing brain health, making a compelling case for the future of cognitive well-being.
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INSIGHT

Composite Brain Age Score

  • NeuroAge combines MRI, cognitive testing, blood biomarkers, and genetics into a single brain-age score called neuro age.
  • Christin Glorioso says roughly 40% of brain aging is lifestyle, making the score actionable for prevention.
INSIGHT

Genetics Versus Lifestyle

  • NeuroAge estimates about 60% of brain aging is genetic and 40% is lifestyle.
  • Christin Glorioso notes lifestyle can mitigate genetic risk, even APOE4 carriers showing younger brain age with good habits.
ADVICE

Use Genetics To Prioritize Action

  • Use a one-time genetic resilience score to understand immutable risk and motivate lifestyle changes.
  • Treat genetics as a signal to prioritize modifiable factors rather than as destiny.
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