The Optispan Podcast with Matt Kaeberlein

The Effects of Rapamycin on APOE4 Carriers & Brain Function | 98

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Feb 11, 2025

The discussion dives into the promising effects of Rapamycin on brain function for APOE4 carriers. It highlights intriguing study findings that suggest potential benefits in brain volume and blood flow. The hosts also debate whether those with the E3/E3 variant might experience similar advantages. Personal anecdotes add a relatable touch, and they ponder the possible implications of Rapamycin in cases of traumatic brain injury. The importance of knowing one's APOE status is underscored, making this a thought-provoking exploration.

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ANECDOTE

Matt Kaeberlein's Rapamycin Experience

Matt Kaeberlein shares his personal experience with rapamycin, noting reduced joint pain.
He emphasizes this is anecdotal and may be placebo, but it aligns with rapamycin's anti-inflammatory effects.

ADVICE

Rapamycin for APOE4 Carriers

Consider rapamycin if you have the APOE4 allele, after consulting a medical professional.
Do not self-medicate with unregulated rapamycin; seek professional guidance.

INSIGHT

APOE Gene Variants

APOE gene variants (E2, E3, E4) produce different forms of apolipoprotein E, impacting lipid transport.
E2 is the most effective variant, E3 is normal, and E4 increases Alzheimer's risk.

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Subscribe to our channel: https://www.youtube.com/@optispanIn this video we discuss current studies relating to Rapamycin use and it's effects on brain function, specifically for APOE4 carriers. This data may (or may not) provide evidence to support the claim that Rapamycin can be beneficial for those with the APOE4 variant.0:00 - Introduction1:58 - Should APOE4 Carriers Take Rapamycin? 3:30 - What is APOE and APOE4? 13:06 - Why Knowing Your APOE Status Matters 15:03 - The Case for Rapamycin and APOE4 Carriers 22:52 - Study Findings32:53 - Comparing Rapamycin to Lifestyle Interventions 37:40 - Could Rapamycin Benefit E3/E3 Carriers? 38:44 - Speculation: Rapamycin and Traumatic Brain Injury Producers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!