The Optispan Podcast with Matt Kaeberlein

Peter Attia: Training, Eating & Optimizing To Live Longer & Healthier In 2025 | 96

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Jan 23, 2025

In this engaging discussion, Dr. Peter Attia shares his expertise on optimizing healthspan for longevity. He breaks down the vital differences between healthspan and lifespan, emphasizing tailored exercise and nutrition. The conversation covers the complexities of processed foods and alcohol, urging a cautious approach. Attia also explores emerging therapies like stem cells and peptides, while critically assessing the hype around various health interventions. Prepare for insights that could reshape your health journey!

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INSIGHT

Purposeful Exercise

Exercise is beneficial, and the specific type matters less initially.
For optimizing long-term health, exercise should be purposeful and cater to individual needs in old age.

ADVICE

Motivating Exercise

Show individuals what they could achieve with better exercise strategies.
This helps motivate them to adopt healthier habits.

INSIGHT

Dietary Balance

Calorie balance is crucial, but it's easier to achieve with a healthy diet.
Extremes in any dietary approach (what, when, how much) are detrimental.

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Subscribe to our channel: https://www.youtube.com/@optispan In this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the benefits of purposeful exercise, and prioritizing dietary factors (what, when, and how much to eat). Our discussion also addresses nuanced views on processed foods, alcohol, and the limitations of trendy approaches like epigenetic clocks. Other topics discussed are interventions such as hormone therapy, rapamycin, metformin, and NAD boosters, offering insights into their potential benefits and current limitations. Experimental therapies like stem cells, peptides, and hyperbaric oxygen are highlighted, emphasizing the importance of evidence-based practices. 0:00 - Introduction: Healthspan vs. Lifespan 3:51 - Exercise for Healthspan and Longevity 7:51 - Nutrition Priorities for Longevity 15:56 - Alcohol: Risks, Benefits, and Nuances 27:10 - Epigenetic Clocks and Biological Age Testing 37:08 - APOE Status and Cognitive Risk 41:25 - STEM Cells & Emerging Experimental Therapies 50:28 - Matt's Lightning Round Questions 1:12:47 - The Hallmarks of Aging Game 1:15:20 - Bonus Question Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!