PsychRounds: The Psychiatry Podcast

Ziprasidone stands out among antipsychotics for its low risk of weight gain and intriguing off-label uses. Its unique interactions with serotonin receptors reveal complex pharmacological properties. The discussion highlights dosing guidelines and potential side effects, including the risk of drug-induced mania. Extrapyramidal symptoms and QTc prolongation are critically examined, shedding light on the clinical considerations required for safe usage. Overall, insights into efficacy and health concerns underscore the importance of careful management when prescribing this medication.

Dive into the intricacies of Paliperidone, an antipsychotic for schizophrenia and schizoaffective disorders, and discover its unique approval journey. Learn about its off-label use for bipolar disorder and the nuances of various long-acting formulations. Get insight into dosing, side effects like hyperprolactinemia, and patient experiences with adherence challenges. Delve into the administration of injectable forms, including transitioning from oral options and addressing patient concerns, all while weighing its efficacy against other medications in the market.

Discover the evolution of risperidone, its significance in modern psychiatry, and how it's used across different age groups. Dive into its mechanism as a D2 blocker and the impact of its active metabolite. Learn about dosing strategies, potential adverse effects like hyperprolactinemia, and the advantages of combining it with aripiprazole. Explore recent advancements such as long-acting injectables, their benefits, and how they enhance treatment options. A fascinating analysis of a pivotal antipsychotic medication awaits!

Dive into the world of Fluphenazine, a potent D2 blocker with a fascinating history in psychiatry. Learn about its FDA approval, off-label uses, and crucial dosage guidelines. Hear about the challenges of acute dystonia and essential safety concerns, especially for elderly patients. Explore Fluphenazine's role as a second-line treatment for hard-to-treat psychotic and mood disorders. Gain insights into its formulations, potential side effects, and the importance of monitoring to ensure efficacy and safety.

Delve into the historical roots of Haloperidol, one of the most widely used first-generation antipsychotics. Discover its unique mechanism as a D2 receptor antagonist and explore its effective applications for psychotic disorders and Tourette's. Learn about various formulations and dosing strategies, including transitioning from oral to long-acting injectables. Critical discussions on the efficacy in managing acute mania and the potential risks, especially for those with renal issues, showcase its complex yet vital role in psychiatric care.

Discover the revolutionary history of chlorpromazine, the first antipsychotic that changed psychiatric treatment. Learn how it was pivotal in improving horrific conditions for patients in the past. Delve into its FDA approvals, primary use for schizophrenia, and the balancing act of its pharmacological effects and side effects, like weight gain and cardiovascular risks. Explore its lasting legacy in psychiatry and even its quirky FDA approval for hiccups. A fascinating dive into the evolution of antipsychotic medication!

Dr. Jason Cafer, an assistant professor of psychiatry and author of Cafer's Psychopharmacology, shares his expertise on antipsychotics and schizophrenia. He emphasizes the significance of choosing the right medication based on individual patient needs and the unique properties of clozapine for treatment-resistant cases. The discussion also covers the pharmacological mechanisms of antipsychotics, including marketing influences and the complexities of loxapine. Cafer advocates for improved education on prescribing practices to enhance patient outcomes.

Dive into the fascinating world of schizophrenia as the hosts unravel its pathophysiology and the pivotal role of dopamine. Discover how genetics intertwine with environmental factors, including childhood adversities. The conversation highlights distinct neurobiological theories, like those around glutamate and serotonin. Key receptors such as muscarinic and GABA are explored for their impact on symptoms and treatment. Lastly, get a glimpse of future possibilities, like gene therapy, that may revolutionize care.

Welcome to our first episode on Schizophrenia! We will be talking about diagnosis, history, treatment, and much more on this mini-series.

On this episode, we will discuss two additional mood stabilizers Carbamazepine (Tegretol) and it's cousin Oxcarbazepine (Trileptal).