PsychRounds: The Psychiatry Podcast The Sleep Series: Melatonin and Ramelteon (Rozerem)
Nov 6, 2024
Explore the fascinating world of sleep aids as the discussion dives into melatonin and remelteon. Discover the key differences between these two popular options, including their effectiveness and regulatory status. Learn about optimal dosing and the potential risks of combining medications. The podcast also highlights safety, side effects, and innovative treatments like Tassi Melteon for better sleep management. Tune in for insights on enhancing sleep quality and upcoming topics on cognitive behavioral therapy for insomnia!
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Melatonin's Role in Sleep Cycle
- Melatonin, produced in the pineal gland, regulates the sleep-wake cycle by acting on MT1, MT2, and MT3 receptors.
- Its levels rise during darkness prompting drowsiness and drop with blue light to promote wakefulness.
Ramelteon vs Melatonin Differences
- Ramelteon is a synthetic melatonin analog with 3 to 16 times stronger binding to MT1 and MT2 receptors and a longer half-life than melatonin.
- It is FDA-approved as a sleep aid, unlike over-the-counter melatonin supplements in the U.S.
Melatonin Quality Control Issues
- Melatonin is sold as an over-the-counter supplement in the U.S. with inconsistent quality and dosage accuracy.
- Studies show up to 70% of products differ significantly from label claims, complicating use and efficacy.