PsychRounds: The Psychiatry Podcast

Explore the intriguing rise of gabapentin, originally approved for seizures, now often used off-label in psychiatry. Delve into its contentious safety profile, revealing concerns about misuse and overdose risks, especially with opioids. Hear about its varied effectiveness in treating anxiety, alcohol use disorder, and even its limited role in bipolar disorder. The hosts break down the pharmacology behind this complex medication, discussing clinical implications and the evolving landscape of its use in mental health.

In this engaging discussion, Dr. Bruce Perry, a leading child psychiatrist and co-author of acclaimed books on trauma, shares insights about his Neurosequential Model of Therapeutics. He breaks down the complexities of trauma, contrasting 'big T' and 'little T' experiences, and emphasizes how these affect child development. Dr. Perry also delves into the significance of emotional regulation, the impact of modern lifestyles on community connections, and the therapeutic power of rhythm. His holistic approach underscores the necessity of tailored treatments for recovery.

Join Dr. Chris Aiken, Editor-in-Chief of the Carlat Psychiatry Report and Yale-trained psychiatrist, as he explores the intriguing spectrum of mood disorders. He discusses the distinction between bipolar disorder and manic-depressive illness, the impact of individual temperaments on treatment, and innovative non-pharmacological strategies. Dr. Aiken also delves into the potential of the keto diet and the role of nutrition in mental health. Plus, insights on sleep patterns and their effects on mood make for a compelling conversation!

Pramipexole, known for treating Parkinson's, is explored for its unexpected role in treatment-resistant depression. The discussion dives into its mood-enhancing effects and unique mechanisms tied to motivation. Safety concerns arise, particularly regarding side effects like impulse control issues. A revealing study highlights pramipexole's potential as an augmentation therapy for depression, showcasing significant symptom improvement. The conversation also emphasizes the risks and benefits of dopamine agonists, urging safe practices in patient management.

In this conversation, Dr. Charles Raison, a prominent psychiatrist and researcher, dives into the fascinating intersection of psychedelics and consciousness. He discusses innovative treatments for depression, including whole-body hyperthermia and Tibetan Buddhist practices like tummo. Raison examines the evolution of consciousness, the influence of technology on mental health, and how psychedelics can enhance neuroplasticity and memory. Listeners will discover the promising potential of integrating ancient practices with modern science.

Dr. Charles Raison, a renowned psychiatrist and professor, dives deep into the biological and evolutionary aspects of depression. He discusses the role of inflammation and the HPA axis in mood disorders. Raison highlights innovative treatments, including psychedelics, and the potential of precision medicine tailored to inflammation responses. The conversation also honors the late Dr. Vladimir Maletic, reflecting on his significant contributions to psychiatry. Listeners gain insights into major depressive disorder's complexities and emerging therapies like pramipexole.

Welcome Back! We have recently partnered with Psych Congress to bring our audience access to some of their leading speakers and educators, and today is the second installment of this endeavor, featuring Dr. Jonathan Meyer on the topic of Antipsychotic plasma level monitoring. Dr. Meyer has authored the handbook on this topic, along with the Lithium and Clozapine handbooks as well. You can find them here: https://www.amazon.com/s?k=jonathan+meyer&crid=3IARW0R4T9RGD&sprefix=jona%2Caps%2C369Psych Congress Discount Code: PSYCHROUNDSConference Website: https://www.hmpglobalevents.com/psych-congressSources:- https://www.cambridge.org/core/books/clinical-use-of-antipsychotic-plasma-levels/E7C0B6DBB4F6031F4D47935154CBEC8D

Dr. Rakesh Jain, a prominent psychiatrist and co-chair of the Psych Congress National Conference steering committee, shares insights on the transformative concept of positive psychiatry. He explores how this holistic approach diverges from traditional methods by integrating lifestyle factors and patient aspirations. The conversation emphasizes the synergy between traditional and positive psychiatry, focusing on resilience and well-being. Jain also discusses the introduction of the WHO-5 scale and how humor and mindfulness can enhance therapeutic experiences.

Discover the intriguing off-label uses of Propranolol, particularly in treating anxiety disorders. The discussion reveals its impact on the central nervous system and how it may assist those with PTSD. Unique dosing guidelines and pharmacokinetics are explored, along with the mixed evidence surrounding its efficacy. The potential of Propranolol to reduce emotional intensity during memory consolidation is examined. The episode also covers clonidine's rapid effectiveness in anxiety treatment, leading to a lively appeal for listener engagement.

Dive into the world of buspirone, a medication used to tackle anxiety, and uncover its rich history and recent FDA approval of jepirone for depression. Learn about the unique pharmacodynamics of buspirone, including its partial agonist function and impressive safety profile. The conversation delves into off-label uses, such as aiding in movement disorders and addressing antidepressant-related sexual dysfunction. Plus, discover how buspirone combines with new treatments like jepirone to enhance outcomes for those battling depression.