PsychRounds: The Psychiatry Podcast

Welcome back! Today, we are discussing a new branded medication that combines bupropion with dextromethorphan for the treatment of depression.

Dive into the world of tricyclic antidepressants, exploring their history and chemical structure. Learn about the differences between secondary and tertiary TCAs and their effectiveness in treating mood disorders. Discover the pharmacokinetics, including dosing and overdose risks, and why careful monitoring is crucial. Get insights on commonly prescribed TCAs, particularly the versatile amitriptyline. Finally, unearth the potential of nortriptyline for severe depression and the vital considerations for drug interactions.

Welcome back! Today, we will be discussing MAOIs, and we've picked out a few of our favorites for today's episode.

Could there be an evolutionary perspective for depression? Join us for part two of our series on depression and inflammation.

Delve into the intriguing link between depression and inflammation. The discussion reveals the evolution of depression's diagnosis and its complex nature. Explore how inflammation affects cognition and treatment responses. Discover the paradox of inflammation in health and its potential benefits. Additionally, learn about the significance of having a purpose in life and its surprising anti-inflammatory effects, which may influence therapeutic approaches.

Join us as we talk about Loxapine, an older medication that’s stood the test of time and found a niche in psychiatric practice.

Junhwan Kim, a fourth-year medical student at CMU College of Medicine and an expert on antipsychotic-induced weight gain, discusses critical strategies to mitigate this common side effect. He highlights the link between antipsychotics and metabolic dysfunction, emphasizing personalized treatment plans. The conversation covers the potential of GLP-1 agonists in promoting weight loss, the challenges patients face accessing these medications, and the importance of non-pharmacological interventions like cognitive-behavioral therapy for effective weight management.

Today, we have a very special guest joining us—Dr. John Kane! We will be discussing his experience and history with clozapine, a groundbreaking medication for treatment-resistant schizophrenia.

Join us and we discuss a newer anti-psychotic medication, Lumateperone, brand name Caplyta.

Dive into the world of cariprazine, a unique antipsychotic with a notable affinity for the D3 receptor. Discover how it tackles negative symptoms of schizophrenia more effectively than some traditional treatments. Safety concerns and side effects are explored, alongside its pharmacokinetics and dosing guidelines. There's a critical look at its performance compared to risperidone and the implications of its cost in clinical practice. Join the conversation on balancing effectiveness and patient care!