PsychRounds: The Psychiatry Podcast

Join us as we talk about Loxapine, an older medication that’s stood the test of time and found a niche in psychiatric practice.

Junhwan Kim, a fourth-year medical student at CMU College of Medicine and an expert on antipsychotic-induced weight gain, discusses critical strategies to mitigate this common side effect. He highlights the link between antipsychotics and metabolic dysfunction, emphasizing personalized treatment plans. The conversation covers the potential of GLP-1 agonists in promoting weight loss, the challenges patients face accessing these medications, and the importance of non-pharmacological interventions like cognitive-behavioral therapy for effective weight management.

Dr. John Kane, a distinguished psychiatrist with decades of experience, dives deep into clozapine, a revolutionary medication for treatment-resistant schizophrenia. He shares its tumultuous history, including safety concerns that challenged its FDA approval. Dr. Kane highlights the drug's underutilization and intricate monitoring requirements that complicate patient access. The discussion extends to new advancements in schizophrenia treatments, underscoring the urgent need for comprehensive education for patients and families in navigating these complex issues.

Join us and we discuss a newer anti-psychotic medication, Lumateperone, brand name Caplyta.

Dive into the world of cariprazine, a unique antipsychotic with a notable affinity for the D3 receptor. Discover how it tackles negative symptoms of schizophrenia more effectively than some traditional treatments. Safety concerns and side effects are explored, alongside its pharmacokinetics and dosing guidelines. There's a critical look at its performance compared to risperidone and the implications of its cost in clinical practice. Join the conversation on balancing effectiveness and patient care!

Welcome back! Brexpiprazole, also known by its brand name Rexulti, is a relatively new medication. Join us for a brief discussion.

Welcome back! Today we are talking about Aripiprazole, brand name Abilify.

This podcast kicks off the new year by diving into Quetiapine, also known as Seroquel, and its wide-ranging uses beyond psychotic conditions. It discusses the unique mechanisms and side effects, including sedation and metabolic concerns. The KDAD trial is highlighted, comparing its effectiveness for Alzheimer's against other antipsychotics. Clinical applications for geriatric patients and anxiety management are explored, as well as the risks associated with off-label use. Overall, a deep dive into the complexities and nuances of this important medication!

Welcome back! Today, we have a short-episode on a unique second generation anti-psychotic, Asenapine (Saphris, Secuado).

Dive into the intriguing world of extrapyramidal symptoms tied to antipsychotic medications. Discover the complexities of acute dystonia and its effective treatment strategies. Unravel the neurological mechanics behind symptoms like akathisia and tardive dyskinesia, and explore promising new treatment options. Understand the critical balance of cholinergic and dopaminergic systems, emphasizing the necessity for early recognition and cautious long-term management of these conditions.