PsychRounds: The Psychiatry Podcast The Antipsychotics: Paliperidone (Invega)
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Sep 18, 2024 Dive into the intricacies of Paliperidone, an antipsychotic for schizophrenia and schizoaffective disorders, and discover its unique approval journey. Learn about its off-label use for bipolar disorder and the nuances of various long-acting formulations. Get insight into dosing, side effects like hyperprolactinemia, and patient experiences with adherence challenges. Delve into the administration of injectable forms, including transitioning from oral options and addressing patient concerns, all while weighing its efficacy against other medications in the market.
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Paliperidone's Unique Indication
- Paliperidone is uniquely FDA-approved for schizoaffective disorder.
- It surprisingly failed FDA approval for bipolar disorder, despite frequent off-label use.
Diverse Antipsychotic Use
- Consider paliperidone for acute mania, maintenance, and even depression in bipolar disorder.
- Explore diverse antipsychotics due to "Invega spamming" for convenience.
Amenorrhea Case
- A young female patient on paliperidone experienced amenorrhea (ceased menstrual cycles) for six months.
- Switching to aripiprazole resolved this side effect, highlighting the impact of medication choice.