PsychRounds: The Psychiatry Podcast The Antipsychotics: Ziprasidone (Geodon)
Sep 25, 2024
Ziprasidone stands out among antipsychotics for its low risk of weight gain and intriguing off-label uses. Its unique interactions with serotonin receptors reveal complex pharmacological properties. The discussion highlights dosing guidelines and potential side effects, including the risk of drug-induced mania. Extrapyramidal symptoms and QTc prolongation are critically examined, shedding light on the clinical considerations required for safe usage. Overall, insights into efficacy and health concerns underscore the importance of careful management when prescribing this medication.
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Ziprasidone's Metabolic Advantage
- Ziprasidone causes little to no weight gain and may even induce mild weight loss.
- This makes it a favorable choice for patients concerned about metabolic side effects of antipsychotics.
Ziprasidone Dosage and Absorption Tips
- Take Ziprasidone oral capsules with at least 500 calories to ensure proper absorption.
- Dosage often needs to be higher, around 120 mg per day, for effective treatment in schizophrenia and bipolar disorder.
Heart and Movement Risks with Ziprasidone
- Ziprasidone prolongs QTC more than other atypicals, limiting its maximum dose.
- Akathisia is a moderately common side effect and should be closely monitored.