PsychRounds: The Psychiatry Podcast The Antipsychotics: Lurasidone (Latuda)
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Oct 2, 2024 Dive into the world of Lurasidone, a game-changing antipsychotic now available as a generic, enhancing patient access. Discover its FDA approval journey and how it effectively treats bipolar depression and schizophrenia, especially in adolescents. Learn about its favorable side effect profile, including minimal weight gain and safety in pregnancy. The conversation also touches on new treatments, like the innovative Cobenify, and speculates on future trends at the intersection of psychiatry and sleep medicine.
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Lurasidone Focus
- Lurasidone is mainly used in bipolar depression rather than schizophrenia nowadays.
- It is recognized alongside lithium and lamotrigine as one of the best for bipolar depressive phase.
Receptor Profile Explains Effects
- Lurasidone antagonizes D2, 5HT2A, with high affinity for D4, 5HT7 linked to cognition.
- Its partial 5-HT1A agonism may explain antidepressant and anxiolytic effects.
Proper Dosing and Food Intake
- Dose lurasidone once daily at night with food to minimize akathisia and maximize absorption.
- Ensure meals with at least 350 calories for effective drug absorption.