The Peter Attia Drive

Mark Messier, a six-time Stanley Cup champion with over 25 years in the NHL, shares his journey from hockey great to leader off the ice. He discusses the importance of humble leadership and teamwork, how he learned from legends like Wayne Gretzky, and the pressure of performing in high-stakes situations. Messier reflects on pivotal moments, his transition to family life, and the challenges of youth sports today. His insights on resilience and personal growth provide a fascinating look at what it takes to thrive under pressure.

Dive into the intriguing concept of how strong intuition can outweigh unreliable medical tests. Historical context and prior knowledge emerge as vital tools for effective decision-making in medicine. The discussion emphasizes the profound impact of intuition on patient care, blending personal stories with professional insights. Preparing for the unexpected becomes crucial as listeners are reminded of the lesser-known yet powerful aspects of medical practice.

Dr. Debra Kimless, an anesthesiologist and Chief Medical Officer at Pure Green Cannabis, and Steve Goldner, the company's Founder and CEO, dive deep into the science of cannabis. They clarify the differences between THC and CBD, discussing their unique interactions with the body and brain. The duo addresses the safety concerns surrounding vaping and the importance of regulation, aiming to shift public perception of cannabis. Moreover, they share insights on the evolving legal landscape for medicinal cannabis and its potential benefits for chronic conditions.

Delve into the fascinating world of rapamycin and its potential in cancer treatment. Discover how this compound interacts with immune function and affects cancer progression differently based on dosage and gender. Learn about the exciting possibilities of combining rapamycin with immune therapies to boost CD8 responses. The discussion also highlights the rising incidence of cancer with age and the decline of immune function, offering hope for interventions that could enhance our defenses against cancer.

In a lively AMA session, experts tackle the nuances of fasting, including why women might face unique challenges and how best to approach it. They delve into the complexities of adolescent dietary choices and the balance between performance and longevity in athletes. Tips for effective learning and memory retention are shared alongside must-read books. Curious questions about personal health tests and the potential stress of health obsession keep the conversation engaging while unraveling the interplay between nutrition, training, and overall wellness.

Discover the fascinating world of NAD and its role in energy production and aging. Learn how boosting NAD levels through supplements could enhance health and longevity. Explore the relationship between NAD and DNA repair mechanisms, including the impact of metformin. Delve into the effects of NAD precursors on mitochondrial health and consider how fasting can influence NAD levels. This engaging discussion unlocks insights into cellular repair and inflammation management, making for a thought-provoking listen.

In this conversation, Ric Elias, founder of Red Ventures and a survivor of US Airways Flight 1549, shares his gripping experiences and insights. He opens up about facing death mid-flight and the profound shift in his perspective that followed. Ric discusses the importance of time as our ultimate currency, reevaluating life success, and raising children amid achievement culture. He also shares powerful anecdotes of gratitude, community responsibility, and his approach to business and philanthropy, making it clear that life is about connections and living without regrets.

Ted Schaeffer, M.D., Ph.D., a leading expert in prostate cancer, returns to discuss crucial topics around screening. He breaks down the complexities of prostate-specific antigen (PSA) levels and their implications for health, using vivid analogies for clarity. The conversation also highlights cutting-edge tests like the 4K score and Prostate Health Index (PHI), which improve risk assessment and diagnostics. Schaeffer emphasizes the importance of distinguishing between aggressive and non-aggressive prostate cancers to enhance patient outcomes.

Sasha Cohen, a former US Olympic figure skater and silver medalist from the 2006 Olympics, opens up about the intense pressures of elite athletics. She highlights the challenges of identity loss post-career and the emotional toll of striving for perfection. Sasha discusses her unforgettable Olympic experience and the uncomfortable truth about the hollowness of achievement. She advocates for redefining success, emphasizing fulfillment over accolades. Their candid conversation sheds light on mental health struggles and the need for a supportive community for athletes.

This podcast dives into the fascinating world of berberine. It explores its unique properties, focusing on how it activates AMP kinase and inhibits PCSK9. The discussion also contrasts berberine's effects with metformin, especially in managing glucose production and high LDL levels. Listeners will gain insights into its clinical applications and potential benefits for health.