The Peter Attia Drive Qualy #57 - A primer on NAD+/NADH, its effect on lifespan/healthspan, and a review of the supplements
Nov 12, 2019
Discover the fascinating world of NAD and its role in energy production and aging. Learn how boosting NAD levels through supplements could enhance health and longevity. Explore the relationship between NAD and DNA repair mechanisms, including the impact of metformin. Delve into the effects of NAD precursors on mitochondrial health and consider how fasting can influence NAD levels. This engaging discussion unlocks insights into cellular repair and inflammation management, making for a thought-provoking listen.
AI Snips
Chapters
Transcript
Episode notes
NAD+ and Aging
- NAD+ levels decline with age, and some believe increasing them could enhance longevity and energy levels.
- Supplements offer NAD+ precursors, aiming to address this age-related decline.
NAD+'s Roles
- NAD+ is crucial for mitochondrial function and energy production.
- It's also vital for sirtuins, enzymes linked to lifespan, and DNA repair.
PARP and NAD+
- The DNA repair enzyme PARP uses significant amounts of NAD+.
- Increased DNA damage with age may contribute to declining NAD+ levels.