The Peter Attia Drive Qualy #52 - Insights about berberine
Nov 1, 2019
This podcast dives into the fascinating world of berberine. It explores its unique properties, focusing on how it activates AMP kinase and inhibits PCSK9. The discussion also contrasts berberine's effects with metformin, especially in managing glucose production and high LDL levels. Listeners will gain insights into its clinical applications and potential benefits for health.
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Berberine and Metformin
- Berberine is a weak AMP kinase activator, similar to metformin, impacting liver glucose production.
- Peter Attia prefers metformin due to its potency and consistent regulation.
Berberine's PCSK9 Inhibition
- Berberine inhibits PCSK9, potentially lowering LDL in some patients.
- This subset of patients may overexpress PCSK9, leading to higher LDL.
Berberine for High LDL
- Give berberine to patients with high LDL.
- Observe its effect without other changes, and if it doesn't work, move on.