The Peter Attia Drive Qualy #61 - Rapamycin in cancer treatment
Nov 19, 2019
Delve into the fascinating world of rapamycin and its potential in cancer treatment. Discover how this compound interacts with immune function and affects cancer progression differently based on dosage and gender. Learn about the exciting possibilities of combining rapamycin with immune therapies to boost CD8 responses. The discussion also highlights the rising incidence of cancer with age and the decline of immune function, offering hope for interventions that could enhance our defenses against cancer.
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Rapamycin's Effectiveness in Cancer Treatment
- Rapamycin's effectiveness against cancer in humans is generally disappointing, especially after diagnosis.
- This might be because tumors evolve to bypass mTOR regulation, rendering rapamycin less effective.
Rapamycin's Dual Impact on Immune System and Cancer
- Rapamycin's impact on the immune system can be a double-edged sword in cancer treatment.
- While boosting immune surveillance could be beneficial, suppressing it could be detrimental.
Mouse Study on Rapamycin Dosage and Sex
- A study with mice showed varying rapamycin effects based on sex and dosage.
- High doses benefited male mice, while female mice developed aggressive hematopoietic cancers.