The Peter Attia Drive

Stanley Perlman, a seasoned expert in coronaviruses and a professor at the University of Iowa, shares his extensive knowledge on the virus's evolution. He highlights the similarities between SARS-CoV-2 and previous outbreaks like SARS and MERS. The discussion includes insights on durable immunity, long-term effects of COVID-19, and future pandemic preparedness. Perlman also details therapeutic strategies and the role of genetic drift in vaccine efficacy, providing a comprehensive overview of what we've learned and how to better prepare for the future.

Dom D’Agostino, an Associate Professor at the University of South Florida and an expert in ketosis research, discusses the ins and outs of the ketogenic diet. He gives practical tips on optimizing health through training, supplements, and intermittent fasting. The conversation explores how genetic factors influence responses to ketogenic diets and examines the long-term effects on thyroid function. With intriguing insights on measuring ketones and the diet's impact on appetite control, D'Agostino delivers a comprehensive look at this popular health trend.

David Watkins, a pathology professor at George Washington University, dives into the fascinating world of immunology. He explains how lessons from HIV and Zika virus research can enhance our COVID-19 strategies. Monoclonal antibodies come into focus as crucial tools for treatment and vaccine development. Watkins breaks down the roles of B and T cells in the immune response, discussing their importance in combating viral infections. He also emphasizes that vaccines don't need to be perfect to be effective, making science accessible and engaging.

Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute and a leading expert in autophagy, shares her groundbreaking insights on the role of autophagy in health and cancer. She discusses how autophagy can paradoxically help cancer cells survive, revealing new avenues for therapies. Eileen also examines the potential of fasting and specific molecules, like rapamycin and metformin, to enhance autophagy for longevity and disease prevention. The complexity of autophagy’s dual role in cancer growth and protection adds depth to the conversation.

A parent shares insights from a discussion with their daughter about George Floyd's death and systemic racism. They explore the complexities of accountability in law enforcement, comparing it with medical training's errors. The conversation highlights the need for active political engagement beyond protests and critiques the lack of discourse in educational spaces. Personal anecdotes about racial profiling lead to a reflection on moral accountability in both professions, advocating for learning from mistakes to improve societal standards.

Ned David, co-founder of Unity Biotechnology and a PhD from Cal Berkeley, dives deep into the science of cellular senescence and its impact on aging. He explains how senolytic medicines could potentially treat age-related diseases like cancer and cardiovascular issues by targeting and eliminating senescent cells. Ned also shares insights on navigating biotechnology entrepreneurship, emphasizing the importance of calculated risks and innovative thinking in transforming ideas into successful companies.

A deep dive into the utility of lab tests reveals their significance in understanding longevity. The discussion highlights critical diseases like atherosclerosis and Alzheimer’s, with a focus on interpreting lab results for better health outcomes. Key insights from patient case studies illustrate how effective testing influences treatment strategies. The conversation further critiques the reactive nature of the healthcare system, advocating for a more proactive approach to prevent chronic illnesses and enhance overall quality of life.

Lew Cantley, a leading cancer biologist and director at Weill Cornell Medical College, delves into his groundbreaking discovery of PI3K, crucial for cancer treatment. He discusses the relationship between sugar consumption, insulin resistance, and tumor growth, revealing the surprising influences of dietary choices on cancer progression. Lew also highlights his innovative clinical trial for stage 4 cancer patients and how synergizing ketogenic diets with PI3K inhibitors can enhance treatment efficacy, reshaping the future of cancer therapies.

John Dudley, a professional archer and skilled educator, shares his passion for archery and its life lessons. He emphasizes the joy of practice and the pursuit of mastery, revealing how a traumatic childhood event shaped his path. Dudley discusses the intricate aspects of archery, the bliss found in focus, and how traits like integrity define successful teaching. He argues for the merits of archery, even for those uninterested in hunting, showcasing it as a powerful model for personal growth and connection to nature.

Fasting fans rejoice! Discover the benefits of switching to a 3-day fasting regimen, including improved ease and metabolic advantages. Get insights on how exogenous ketones impact insulin, blood glucose, and autophagy. Explore ketone measuring methods, from breath tests to blood monitors. Plus, enjoy practical tips for navigating multi-day fasts and how dietary choices can enhance your fasting experience. This is a treasure trove of knowledge for anyone looking to boost longevity through mindful eating and exercising!