#108 - AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity
Apr 21, 2020
Fasting fans rejoice! Discover the benefits of switching to a 3-day fasting regimen, including improved ease and metabolic advantages. Get insights on how exogenous ketones impact insulin, blood glucose, and autophagy. Explore ketone measuring methods, from breath tests to blood monitors. Plus, enjoy practical tips for navigating multi-day fasts and how dietary choices can enhance your fasting experience. This is a treasure trove of knowledge for anyone looking to boost longevity through mindful eating and exercising!
15:30
forum Ask episode
web_stories AI Snips
view_agenda Chapters
auto_awesome Transcript
info_circle Episode notes
question_answer ANECDOTE
Fasting Switch
Peter Attia switched from quarterly 7-day fasts to monthly 3-day fasts.
He found 3-day fasts less disruptive and allows for higher exercise tolerance.
insights INSIGHT
Metabolic Changes in Fasting
Peter Attia hypothesizes that key metabolic changes occur around day two or three of a fast.
He aims to capture these benefits with shorter, more frequent fasts.
volunteer_activism ADVICE
Modified Keto Diet
While not strictly keto, Peter Attia follows a lower-carb diet.
He restricts sugar and starch, primarily eating vegetables and fiber.
Get the Snipd Podcast app to discover more snips from this episode
In this “Ask Me Anything” (AMA) episode, Peter explains some observations he’s noticed since switching to a 3-day fasting cycle from the longer fasts, the various things he’s measuring, and some helpful tips for getting through a prolonged fast. He also discusses the role of exogenous ketones in fasting and ketogenic diets as well as their impact on autophagy, specifically. Finally, Peter provides some practical advice for those looking to fit exercise for longevity into their busy life. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA.
If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #13 show notes page. If you are not a subscriber, you'll be able to listen to a sneak peak of this episode.
We discuss:
Peter’s observations since switching from a 7-day to a 3-day fasting regimen [1:25];
Ketone measuring devices—blood and breath [7:40];
Can zero-calorie sweeteners affect ketone production? [10:40];
Will there be a continuous insulin monitor anytime soon? [11:55];
Exogenous ketones—Role in fasting and ketogenic diets and their effect on insulin, blood glucose, and autophagy [14:10];
5 tips to help you get through a multi-day fast [25:55];
Relationship between BHB levels, glucose levels, and autophagy—Are high levels of ketones enough to produce autophagy? [34:10];
Why is measuring blood insulin so much harder than blood glucose? [36:55];
Advice and resources for people wanting to stay up to date on developments related to health and longevity (and how to quickly sift through all the bad science) [40:10];
Advice for those looking to fit exercise for longevity into their busy life [51:10]; and
The Peter Attia Drive