The Peter Attia Drive #117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19
Jun 29, 2020
Stanley Perlman, a seasoned expert in coronaviruses and a professor at the University of Iowa, shares his extensive knowledge on the virus's evolution. He highlights the similarities between SARS-CoV-2 and previous outbreaks like SARS and MERS. The discussion includes insights on durable immunity, long-term effects of COVID-19, and future pandemic preparedness. Perlman also details therapeutic strategies and the role of genetic drift in vaccine efficacy, providing a comprehensive overview of what we've learned and how to better prepare for the future.
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SARS Origin and Spread
- SARS originated in a live animal market in Guangzhou, spreading from bats to other animals and then to humans.
- A physician, infected in the market, traveled to Hong Kong and spread the virus globally.
SARS R0 and Transmission
- SARS had an R0 of two to three, but this varied based on environment and disease progression.
- Spread was more likely within hospitals due to procedures aerosolizing lung fluids, increasing transmission.
SARS Mortality Rate
- SARS's quoted 10% mortality rate is likely the case fatality rate, not infection fatality rate.
- Many more may have been infected with milder symptoms, lowering the actual mortality rate.