The Peter Attia Drive

Dive into a nutritional journey exploring the complexities of fruits and vegetables. Discover how your health status shapes your dietary choices and why eating whole fruits differs from drinking their juices. Unpack the intricate world of phytochemicals and their potential benefits and drawbacks. Learn about metabolic health beyond just BMI and the role of fiber in your diet. The episode also touches on the murky waters of nutritional data, shedding light on the challenges of making informed recommendations.

Benoît Arsenault, a leading researcher from Laval University, dives deep into the genetics of Lp(a), a crucial factor in heart disease. He discusses how Lp(a) is inherited and its significant role in cardiovascular risk. The conversation highlights the challenges of measuring Lp(a) levels and the emerging treatments like antisense oligonucleotides. Benoît also explains why traditional statins don’t adequately address Lp(a) and underscores the importance of identifying this genetic marker for better heart health outcomes.

Marty Makary, a surgeon and public policy expert, dives deep into patient safety and medical errors. He explores the alarming frequency of medical mistakes and the historical shifts in safety culture. The high-profile RaDonda Vaught case is highlighted, revealing its impact on the push for better protocols. Makary also shares strategies for advocating for loved ones in hospitals and emphasizes the need for systemic reforms to truly reduce error rates. Hope shines through as he discusses the path forward for improved safety in healthcare.

Kelsey Chittick, author of "Second Half: Surviving Loss and Finding Magic in the Missing," shares her impactful journey of healing after the sudden death of her husband, former NFL player Nate Hobgood-Chittick. She discusses the challenges of parenting through grief, her experiences with psychedelics, and the concept of radical acceptance. Kelsey reflects on navigating trauma, the complexities of mental health, and how she’s rediscovered happiness in life’s unpredictability, offering profound insights into healing and resilience.

Join Dr. Matt Kaeberlein, a leading researcher in aging from the University of Washington, as he dives into the fascinating world of anti-aging compounds. They explore the roles of NAD+, metformin, and rapamycin, discussing their potential in extending lifespan. Tune in for insights into aging biomarkers and the challenges in understanding epigenetic clocks. Kaeberlein shares skepticism surrounding commercial aging tests and emphasizes the need for thorough research models to make informed decisions in longevity science.

Explore the keys to longevity through exercise! Discover how strength training and techniques like deadlifts play a crucial role in maintaining muscle mass as we age. Learn about the benefits of zone 2 and zone 5 training for optimizing aerobic capacity and cardiovascular health. Delve into the concept of the 'Centenarian Olympics' and the importance of functional fitness tailored for a vibrant life into your 100s. Plus, gain insights into balancing exercise routines and why stability should be at the core of all movement.

Layne Norton, Ph.D., a leading expert in nutritional sciences and a renowned physique coach, dives deep into the science of energy balance and its impact on body composition. He explains how tracking calories can be tricky and offers tailored nutrition advice for individuals at different life stages. The conversation highlights the crucial role of protein and resistance training in muscle gain and metabolic health. Layne also discusses effective supplement options like whey protein and creatine, demystifying their benefits for fitness enthusiasts.

Nir Barzilai, M.D., the Director of the Institute for Aging Research at Albert Einstein College of Medicine, shares groundbreaking insights about longevity. He reveals genetic clues from centenarians, discussing how specific gene variants contribute to long lifespans. The conversation explores the TAME trial, emphasizing the potential of metformin as a longevity tool and its varied impacts on health. Barzilai also touches on epigenetic clocks and the controversial role of NAD precursors in aging, inviting listeners to reconsider their understanding of what it means to live a longer, healthier life.

Dive into the silent threat of atherosclerosis, the leading cause of heart disease. Discover how this condition can start early in life and the critical role cholesterol plays in our health. Learn about essential risk factors and the importance of preventive measures to combat this pervasive issue. Explore the significance of diagnostic tests like coronary artery calcium scores and their impact on understanding heart health. Finally, grasp key takeaways for effective prevention strategies against cardiovascular disease.

Join Nick Stenson as he chats with Peter Attia about his evolving views on health and wellness. They delve into advancements in cancer immunotherapy and the importance of aggressive screening for colorectal cancer. Peter discusses the significance of ApoB levels in cardiovascular risk and the role of genetics in Alzheimer’s disease. They also explore the benefits of time-restricted feeding, the complexity of nutrition, and the intriguing connection between psychedelics and mental health. Plus, don't miss a lively discussion on Formula 1 racing strategies!