Dr. Marco Seandel, a researcher from Weill Cornell Medical College, discusses his groundbreaking work on spermatogonial stem cells and how they reveal mutations in aged male sperm. He dives into the implications of paternal age on genetic disorders, such as Apert syndrome. The conversation is rich with insights on stem cell behavior and the balance of mutations in sperm development. Alongside humor, they touch on the challenges of collecting tissue samples and the inequities faced by researchers in academia, making for an engaging exploration of science.

Dr. Daylon James, an assistant professor at Weill Cornell Medical College and expert in stem cell biology, shares insights from his groundbreaking research on utilizing the vascular niche to transform endothelial cells into blood stem cells. The conversation dives into the significance of this niche in stem cell differentiation and its potential clinical applications. They also reflect on alarming disease outbreaks and fascinating studies about genetic similarities among friends, adding a layer of humor and depth to the serious scientific discussions.

Dr. Paul Tesar, an assistant professor at Case Western Reserve University, shares his insights on pluripotent stem cells and enhancer activity. He discusses groundbreaking research, including how stem cell transplants can reverse sickle cell anemia and the role of gut bacteria in transplant success. Tesar also elaborates on the distinctions between naive and primed stem cells, crucial for understanding pluripotency. With a humorous take on life outside the lab, he highlights the balance needed for a fulfilling scientific career.

Guest: This is a special episode consisting of over 75 minutes of live interviews. Last week The Stem Cell Podcast attended the International Society for Stem Cell Research meeting and pulled people aside to get their take on the meeting and stem cell research. We compiled all the interviews into one show for you to enjoy. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dr. Dieter Egli, a senior research fellow at the New York Stem Cell Foundation, dives into the fascinating world of somatic cell nuclear transfer (SCNT) and its application in generating embryonic stem cell lines. He shares insights from his groundbreaking research on creating therapeutic cells for diabetes. The conversation also navigates the ethical challenges of egg donation for research and public perceptions surrounding SCNT. Egli's journey highlights both the promising advancements and the complexities inherent in the evolving landscape of stem cell science.

Dive into the fascinating world of stem cell research! Discover the largest sperm ever found, and learn why some stem cells aren't making hearts. Innovative heart-on-a-chip technology steals the spotlight, while researchers unveil a new element on the periodic table. Delve into the intriguing realm of iPSCs from schizophrenia patients. And don’t miss the humorous rant about bathroom air fresheners that wraps up this lively discussion!

Dr. Kevin Eggan, a professor at Harvard, is on a mission to tackle ALS using stem cells. He shares groundbreaking insights into the role of the C9orf72 gene, often overlooked in ALS research. The conversation dives into environmental factors linked to the disease, exploring intriguing cases involving athletes and military personnel. Eggan also highlights the challenges in replicating scientific studies and the desperate need for funding to advance innovative research in this vital field. Exciting findings promise hope for future ALS treatments!

Dr. Chris Smith, the founder of The Naked Scientists and a science communicator with an MD-PhD from Cambridge, dives into the fascinating world of stem cells. He discusses groundbreaking advancements like lab-grown tissues and the ethical debates surrounding cloning. The conversation highlights how stem cell research is revolutionizing personalized medicine and the implications for neurodegenerative diseases. Additionally, Chris shares his journey from medical student to podcaster, emphasizing the importance of making science accessible.

Dr. Raja Kittappa, a former stem cell scientist known for his research on Parkinson's disease, is now running for Congress in Pennsylvania. He discusses the financial challenges of political campaigns from a scientist's viewpoint, stressing the importance of funding for scientific advocacy. Raja shares his motivations rooted in personal experiences with health crises and emphasizes the need for greater representation of science in politics. The conversation also touches on innovative research in neuroscience and the influence of government on scientific progress.

Dr. Leonard Zon, an acclaimed stem cell and cancer researcher from Harvard, discusses his groundbreaking work with zebrafish in cancer studies. He shares amusing anecdotes about transporting these fish and the unexpected chaos that ensued. The conversation covers the advantages of zebrafish as model organisms for understanding melanoma, especially concerning genetic mutations and innovative treatment strategies. Zon also emphasizes the future of stem cell applications in personalized medicine, enriching our understanding of cancer biology.