Ep. 30: Nobel Conversation Featuring Dr. Harold Varmus
Oct 27, 2014
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In this conversation with Dr. Harold Varmus, a Nobel Prize-winning scientist and director of the National Cancer Institute, they explore his groundbreaking contributions to cancer research and the challenges of securing NIH funding. The discussion highlights inspiring breakthroughs in cell transplantation for paralyzed patients and Gene therapy for genetic diseases. They also touch on the impact of diet on aging and the need for a supportive environment for young researchers. Humor weaves through critiques of scientific authorship, making it a compelling listen.
Dr. Harold Varmus emphasizes the need for increased financial support for young biomedical researchers to foster innovation and stability.
Varmus discusses the shifting age trend in grant recipients, posing challenges for new graduates in securing funding and stability in academia.
The podcast highlights various career paths available to biomedical PhD graduates beyond academia, promoting adaptability in a changing job market.
Deep dives
Interview with Nobel Prize Winner Dr. Harold Varmus
Dr. Harold Varmus, Nobel Prize-winning scientist and current director of the National Cancer Institute, shares insights into his career and the current landscape of biomedical research. His groundbreaking work in discovering retroviral oncogenes highlights the potential impact of scientific research. Varmus discusses the challenges young researchers face in securing funding and establishing their labs, specifically addressing the trend of older individuals receiving major grants. He emphasizes the necessity of creating a supportive environment for young scientists and suggests that graduate schools should provide more tailored mentorship.
The Importance of Funding Young Investigators
Varmus underscores the critical need for increasing financial support for young investigators within the biomedical field. He notes that historically, the average age for securing grants has shifted upward, making it difficult for new graduates to find stability in academia. The health of the research community relies on nurturing younger talent, ensuring the scientific workforce remains innovative and dynamic. Addressing this issue requires a multi-faceted approach, including potentially reallocating NIH funding to better support early-career researchers.
The Malthusian Challenge in Biomedical Research
Varmus refers to the 'Malthusian dilemma' within biomedical research, where the growth of the research community outpaces available funding. He cautions that simply increasing the NIH budget won't solve underlying issues, as competition will remain fierce among researchers vying for limited resources. The challenge lies in balancing the number of aspiring scientists with the capacity of the funding system to support them. By fostering a community that prioritizes collaboration and mentorship, the ecosystem can stabilize and thrive.
Expanding Career Opportunities for Scientists
The conversation shifts toward the varied career paths available to biomedical PhD graduates, emphasizing that academia is not the only viable option. Varmus highlights alternative careers in industry, teaching, and even entrepreneurship, which can benefit from scientific training. By broadening career perspectives, researchers can find fulfilling opportunities that align with their skills and interests outside of traditional academic roles. This adaptability not only enriches the individual career trajectory but also enhances the overall scientific community.
Implications of the Ebola Outbreak
Towards the end of the discussion, the ongoing Ebola outbreak is mentioned, although Varmus refrains from detailed commentary due to the politicization of the issue. He emphasizes the importance of listening to public health experts and scientists when addressing such crises. Understanding the nuances of epidemiology is crucial for managing infectious diseases and preventing widespread panic. Effective communication and collaboration among scientists and health officials can lead to better public health outcomes during outbreaks.
Guest:
In this episode we welcome Nobel Prize winning scientist, Dr. Harold Varmus. We talk with Dr. Varmus about a range of topics in the realm of biomedical research as a career and the state of NIH funding.
Resources and Links
Motor Skill Learning Requires Active Central Myelination – The production of new myelin in the brain, which is a function of non-neuronal glial cells, may be necessary for motor learning.
A Global Inventory of Lakes Based on High-resolution Satellite Imagery – Researchers were able to accurately count the lakes on earth with high resolution data from satellites.
UCL Research Helps Paralyzed Man to Recover Function – Researchers announced that two years after the cell transplant, a man paralyzed from chest down was able to walk again.
Soda and Cell Aging: Associations between Sugar-Sweetened Beverage Consumption and Leukocyte Telomere Length in Healthy Adults from the National Health and Nutrition Examination Surveys – Research found found that telomeres – protective DNA caps on the end of chromosomes – were shorter in people who reported habitually drinking more fizzy drinks.
Promising Early Success and Safety Results from International Gene Therapy Trial for 'Bubble Boy' Disease Reported in New England Journal of Medicine – This article describes a new form of gene therapy for boys with X-linked severe combined immunodeficiency syndrome (SCID-X1), a life-threatening condition also known as “bubble boy” disease.
Manipulating a “Cocaine Engram” in Mice – Researchers examine the precise neural circuits that support the memory of a cocaine-cue association or “cocaine engram” in mice.
Left–Right Dissociation of Hippocampal Memory Processes in Mice – This article shows that hippocampal long-term memory processing is lateralized in mice after investigating the implications of left-right difference in hippocampal function.
Histone H2A.Z Subunit Exchange Controls Consolidation of Recent and Remote Memory – According to this article, histone variant exchange can be a novel mechanism contributing to the molecular basis of cognitive function and implicate H2A.Z as a potential therapeutic target for memory disorders.
Rise of the Rest: The Growing Impact of Non-Elite Journals – This article shows that the fraction of highly-cited articles published in non-elite journals has increased steadily from 1995-2013 and researchers are increasingly building on and citing work published everywhere.
Reports of Pathological Gambling, Hypersexuality, Compulsive Shopping Associated with Dopamine Agonist Drugs – This article examines the effect of dopamine receptor agonist drugs which are used to treat Parkinson’s disease, restless leg syndrome and hyperprolactinemia, on patients with impulse control disorders.
Human Genetic Research Uncovers How Omega-6 Fatty Acids Lower Bad Cholesterol – Researchers uncovered a gene that affects blood cholesterol levels through the generation of a compound from omega-6 polyunsaturated fatty acids, called lipoxins.
Are Male Brains Wired to Ignore Food for Sex? – This article describes how male C. elegans, a microscopic roundworm that is widely used in studying fundamental mechanisms in biology, suppresses their ability to locate food in order to instead focus on finding a mate.
Ultra-fast Charging Batteries that Can Be 70% Recharged in Just Two Minutes – Scientists from Nanyang Technological University have developed a new battery that can be recharged up to 70% in only two minutes and also have a longer lifespan of over 20 years.
Stem-Cell Fraud Makes for Box Office Success – The movie, Whistleblower, which was based on the Woo Suk Hwang cloning scandal, has been a box office hit in South Korea.
Stem Cells for Diabetes: The Danger of the Word ‘Cure’ – This article discusses the danger in loosely using the word ‘cure’ as it falsely raises hopes and expectations of patients and other people.
Paralyzed Man Walks Again after Nose Cells Repair His Spinal Cord – A man paralyzed from the chest dow...
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