

The Metabolic Link
Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field
Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This is where science meets society.
Episodes
Mentioned books

Sep 24, 2024 • 1h 7min
C15: The Essential Fatty Acid Transforming Metabolic Health & Aging | Dr. Stephanie Venn-Watson | Ep.50
Dr. Stephanie Venn-Watson, a veterinary epidemiologist and public health scientist, dives into her innovative research about C15:0, a newly identified essential fatty acid found in dolphins. This fatty acid may hold the key to enhancing metabolic health and longevity, showcasing benefits that surpass omega-3s. Discover how C15:0 could tackle inflammation and insulin resistance, along with groundbreaking insights into its implications for human health. Stephanie reveals its potential to reshape our understanding of diet and aging, making it a true game-changer.

Sep 10, 2024 • 51min
Jeff Volek, PhD, RD | Exploring the Keto-Adapted Phenotype: Focus on Muscle | The Metabolic Link Ep.49
Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of The Metabolic Link, recorded at Metabolic Health Summit 2024, we share Dr. Jeff Volek's full presentation where he takes a deep dive into the "Keto-Adapted Phenotype" with a focus on muscle. Dr. Volek, a leading expert in low-carbohydrate and ketogenic diets, shares groundbreaking research on how ketones impact muscle function and performance. Dr. Volek explores the intricate ways ketones influence muscle glycogen metabolism, ketone production in skeletal muscle, and even heart function.Dr. Volek unpacks underappreciated aspects of ketosis, such as how muscle glycogen can be preserved and replenished without the need for high carbohydrate intake, the role of ketones in cardiac health, and how skeletal muscles may play a part in ketone metabolism. This thought-provoking episode not only challenges conventional ideas about energy and performance but also offers insights for athletes, health professionals, and anyone interested in optimizing metabolic health.About Dr. VolekDr. Volek is a registered dietitian and professor in the Department of Human Sciences at The Ohio State University. For the last 25 years, he has performed translational research on how humans adapt to ketogenic diets with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 350 peer-reviewed scientific manuscripts and five books. Dr. Volek is the Chief Science Officer and Co-Founder of Virta Health, the first clinically proven treatment to safely and sustainably reverse type 2 diabetes at scale without medications or surgery. Dr. Volek has a Bachelor of Science in dietetics from Michigan State University, and a Master of Science in exercise physiology and Doctorate in kinesiology and nutrition from Pennsylvania State University.Special Thanks to our Episode Sponsors: * Genova Connect, powered by Genova Diagnostics - Receive 15% off any of their tests with code METABOLICLINK: https://connect.gdx.net/themetaboliclink* Fatty 15 - Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK: https://fatty15.com/METABOLICLINK* Ned - Get 15% off Ned products with code METABOLICLINK at http://helloned.com/metaboliclinkIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Aug 27, 2024 • 1h 20min
Nick Norwitz, PhD | The Future of Medicine & Metabolic Health | The Metabolic Link Ep.48
Dr. Nick Norwitz, a PhD holder and advocate for personalized medicine, shares insights on the future of metabolic health. He discusses the shift from traditional trials to individualized care, emphasizing genetic insights and new technologies like continuous glucose monitors. Dr. Norwitz underscores how advances in AI and multi-omics data can personalize treatments, revolutionizing healthcare. His journey as a researcher and educator offers inspiration, particularly for pre-med students, highlighting the importance of engaging with emerging metabolic health tools.

14 snips
Aug 13, 2024 • 1h 5min
Dr. Chris Palmer | Brain Energy: The Metabolic Theory of Mental Illness | The Metabolic Link Ep. 47
In this enlightening discussion, Dr. Chris Palmer, a renowned Harvard psychiatrist and researcher, explores the intriguing link between metabolic dysfunction and mental illness. He addresses the alarming rise in mental health disorders and critiques existing treatment frameworks. Dr. Palmer introduces his 'Brain Energy' theory, proposing metabolic dysfunction as a possible root cause. He also highlights the benefits of the ketogenic diet and underscores the importance of a holistic approach, urging us to rethink mental health diagnostics.

Jul 30, 2024 • 2h 7min
Infections, Inflammation, and Alzheimer's Disease with Mary Newport, MD | The Metabolic Link Ep.46
Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here!In this enlightening episode of The Metabolic Link, Dr. Dominic D'Agostino sits down with Dr. Mary Newport to delve into the world of Alzheimer's disease, discussing her pioneering work with ketogenic metabolic therapy. Dr. Newport shares her personal and inspiring journey with her husband, Steve, whose battle with early-onset Alzheimer's led her to discover the life-changing effects of MCT and coconut oil. Dr. Newport also explores the crucial role of nutrition in managing Alzheimer's, the potential of exogenous ketones, and the intriguing hypothesis that links infections to the disease.About Mary Newport:Dr. Mary Newport, M.D., is a seasoned pediatrician and neonatologist with over thirty years of experience. She has been involved in founding and directing neonatal intensive care units in the Tampa Bay area. Transitioning later in her career to home hospice care and health risk assessments, Dr. Newport witnessed firsthand the transformative effects of a ketogenic nutritional intervention using coconut and medium-chain triglyceride oil on her husband, who had early-onset Alzheimer’s disease. She has since become an internationally recognized author and speaker, advocating for ketones as a brain fuel alternative.Two recent papers by Dr. Newport:Ketogenic Strategies for Alzheimer’s Disease and Other Memory Impairments: History, Rationale, and 288 Caregiver Case ReportsThe Lipid–Heart Hypothesis and the Keys Equation Defined the Dietary Guidelines but Ignored the Impact of Trans-Fat and High Linoleic Acid ConsumptionSpecial thanks to the sponsors of this episode:Genova Connect, powered by Genova Diagnostics is giving you 15% off any of their tests with code metaboliclink here. Fatty15 is offering you 15% off their 90-day subscription Starter Kit by going visiting this link and using code METABOLICLINK.Timeline is offering 10% off your first order of Mitopure. Visit this link & use code METABOLICLINKIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Jul 16, 2024 • 58min
Metabolic Therapy for Serious Mental Illness | Dr. Deanna Kelly, Pharm.D., BCPP | The Metabolic Link Ep.45
Dr. Deanna Kelly discusses metabolic therapies for mental illness, including the use of ketogenic diet for schizophrenia. They explore the impact of diet on mental health, metabolic dysfunction in mental illness, personalized medicine, and challenges in implementing metabolic therapy.

Jul 2, 2024 • 57min
Dr. Robert Lustig | Obesogens: The Hidden Driver of Obesity | The Metabolic Link Ep. 44
Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of the Metabolic Link Podcast, host Dr. Dom D'Agostino sits down with Dr. Robert Lustig to discuss groundbreaking research unifying different models of obesity. They dive deep into the flaws of the traditional energy balance and carbohydrate-insulin models and introduce a compelling integrative theory encompassing the impact of obesogens, redox biology, and reactive oxygen species (ROS) on metabolic health. The conversation navigates through a review article by Dr. Lustig and others on obesogens from the International Journal of Obesity, dissecting specific obesogens like bisphenol A, phthalates, and glyphosate, and examining how different foods and lifestyle choices can mitigate their effects. This episode is a must-listen for anyone interested in nutritional science, metabolic health, and the future of obesity research.About Dr. LustigRobert H. Lustig, M.D., M.S.L. is Emeritus Professor of Pediatrics in the Division of Endocrinology, and Member of the Institute for Health Policy Studies at UCSF. Dr. Lustig is a neuroendocrinologist, with expertise in metabolism, obesity, and nutrition.To learn more about Dr. Lustig, please visit: https://robertlustig.comSpecial thanks to our sponsors:Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclinkLMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at https://drinklmnt.com/metaboliclinkAquaTru is a reverse osmosis water purifier that uses a 4-stage purification process. Their countertop purifiers work with NO installation and remove 83 dangerous contaminents. Get 20% OFF any AquaTru purifier by using the code METABOLICLINK at AquaTru.comReferenced Papers:Obesogens: a unifying theory for the global rise in obesityDo We Need a New Unifying Theory for Obesity?In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

9 snips
Jun 18, 2024 • 1h 16min
Take Control of Your Metabolic Health with Dr. Casey Means | The Metabolic Link Ep. 43
Dr. Casey Means, a Stanford-trained physician and co-founder of Levels, shares her inspiring journey from a head and neck surgeon to an advocate for metabolic health. She discusses how personal experiences with family illness sparked her mission. Dr. Means highlights environmental factors affecting mitochondria and offers practical steps to enhance metabolic health. She emphasizes the interconnection of trauma, emotional well-being, and cellular health and provides actionable tips for a sustainable lifestyle that promotes energy and vitality.

Jun 4, 2024 • 22min
Lily Nichols, RDN, CDE | Optimizing Pregnancy and Metabolic Health | The Metabolic Link Ep.42
Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs! Registered dietitian, Lily Nichols, RDN, CDE, is back on The Metabolic Link, this time in an intimate interview that dives into the critical links between metabolic health, perinatal nutrition, and long-term wellbeing. This episode dives deep into how nutrition during the childbearing years can affect not only mothers but their children throughout their lives.Lily, who is also a New York Times bestselling author of key books on prenatal nutrition, unpacks the significance of blood sugar balance, the role of various micronutrients, and the timing and composition of meals in optimizing fertility and pregnancy health. She shares her expertise on managing gestational diabetes through dietary adjustments and explains how both maternal and paternal health can influence pregnancy outcomes. Additionally, the conversation includes discussions around fertility treatments and assisted reproductive technologies.About Lily Nichols, RDN, CDE:Lily Nichols is a Registered Dietitian/Nutritionist, Certified Diabetes Educator, researcher, and author with a passion for evidence-based nutrition. She is the founder of the Institute for Prenatal Nutrition®, co-founder of the Women’s Health Nutrition Academy, and the author of three books: Real Food for Fertility, Real Food for Pregnancy, and Real Food for Gestational Diabetes.We're hosting a Live Q&A with Lily Nichols as a follow up to this episode on June 12th at 8am PT/11am ET! Bring your questions and join our medical education platform with a FREE 7-day free trial. Click here to register. Special thanks to our sponsors:Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclink LMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at https://drinklmnt.com/metaboliclinkTimeline, a Swiss based life science company, is a global leader in Urolithin A research. Timeline is offering 10% off your first order of Mitopure. Go to timeline.com/METABOLICLINK & use code METABOLICLINKIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

27 snips
May 21, 2024 • 53min
Mitochondrial Health and Urolithin A with Dr. Anurag Singh | The Metabolic Link Ep. 41
Dr. Anurag Singh, CMO of Timeline, discusses Urolithin A's impact on mitochondrial health, muscle strength, and inflammation. They explore mitophagy, synergistic effects with ketones, and transdermal delivery systems. Urolithin A's potential in combatting age-related decline and future applications is also highlighted.


