Journal Club: Metabolic Overdrive in Bipolar Disorder | The Metabolic Link Ep.51

Oct 8, 2024

Dive into the revolutionary Metabolic Overdrive Hypothesis, linking energy dysregulation in the brain to bipolar disorder. Explore parallels with epilepsy and how brain energy demands shift during manic and depressive phases. Learn about ketosis and its potential to stabilize symptoms by restoring mitochondrial function and reducing excessive glutamate. As they tackle practical challenges and barriers in adopting ketogenic therapy, the conversation uncovers a promising new frontier in mental health treatment.

Ask episode

AI Snips

Chapters

Transcript

Episode notes

ANECDOTE

Matt Buzski's Ketogenic Recovery Story

Matt Buzski went from homelessness to remission of bipolar symptoms using a ketogenic diet and other changes.
His family's activism helped fund research and increase mainstream attention.

INSIGHT

Energy Dysregulation As Core Pathology

Bipolar disorder likely involves core brain energy dysregulation, not just neurotransmitter imbalance.
The paper argues metabolic dysfunction is central to bipolar pathophysiology and links it to epilepsy.

INSIGHT

Mania And Depression As Energy Extremes

Mania is a high-energy brain state and depression a low-energy state in bipolar disorder.
These opposing phases suggest a metabolic toggle driving behavioral extremes.

Get the Snipd Podcast app to discover more snips from this episode

Get the app

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here.

In this journal club episode of The Metabolic Link, we explore the cutting-edge "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain’s energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harry Campbell, proposes that mitochondrial dysfunction forces the brain into a hypermetabolic state, leading to manic episodes.

We discuss how this groundbreaking research links bipolar disorder to epilepsy and how therapeutic ketosis—through diet or supplementation—might restore energy balance, reduce manic episodes, and complement traditional medications.

With the potential to reshape psychiatric treatment, you won't want to miss this paper or journal club episode! Read the full paper here: https://www.nature.com/articles/s41380-024-02431-w

Special thanks to the sponsors of this episode:

Genova Connect - Receive 15% off any of their tests with code METABOLICLINK here
Fatty15 - Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK here
Ned - Get 15% off Ned products with code METABOLICLINK here

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.