The Metabolic Link

In this engaging debate, Dr. Richard Johnson, an expert on the impact of fructose in obesity, and Dr. Layne Norton, a nutrition scientist and bodybuilder, clash over the root causes of America’s obesity crisis. They explore the roles of sugar-sweetened beverages, leptin resistance, and the intricacies of energy balance versus fructose consumption. Both agree on one point: our food environment significantly contributes to metabolic dysfunction. Their lively discussion challenges common perceptions surrounding diet and weight management.

In this engaging discussion, Dr. Anthony Chaffee, a medical doctor and nutrition educator, dives deep into the benefits of an animal-based ketogenic diet for metabolic health. He challenges conventional dietary beliefs, highlighting the transformative potential of carnivore diets on chronic diseases and inflammation. Sharing personal anecdotes and clinical insights, Dr. Chaffee discusses the impact of fatty acids and explores the role of diet in autoimmunity. His findings suggest a reexamination of our dietary choices for better health outcomes.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health and therapy, and earn CMEs here!In this deeply personal and courageous episode of The Metabolic Link, we hear from patient advocate and podcast co-host Matt Baszucki, who shares how he endured—and ultimately overcame—type 1 bipolar disorder through a radical shift in treatment: ketogenic metabolic therapy.After years of hospitalizations, debilitating mood episodes, and failed conventional treatments, Matt found hope through the emerging field of metabolic psychiatry. With the help of his family, including support and clinical guidance from Dr. Christopher Palmer, Matt adopted a therapeutic ketogenic diet in 2021—and the results were extraordinary.Now a thriving project manager in Silicon Valley and co-host of The BipolarCast, Matt is helping drive a movement that challenges the very foundation of how we treat mental illness. This episode is not just about recovery—it's about transformation, resilience, and the future of mental health care.Special thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here✅ iRestore – Get a huge discount when you use the code METABOLICLINK hereWatch Matt Baszucki's YouTube Channel here and Bipolar Cast here. Learn more about the non-profit, Metabolic Mind, here. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Dr. Kyle Gillett, a dual board-certified physician in family and obesity medicine, shares his expertise on optimizing hormone levels for better health. He discusses the critical impact of hormones on performance and longevity, emphasizing lifestyle interventions for balance. Gillett dives into essential fatty acids like C15 and their benefits, along with insights on testosterone's role and timing in hormone testing. He also highlights links between hormones and mental health, particularly postpartum depression, showcasing the complex interplay of hormonal regulation.

Explore the alarming rise of non-alcoholic fatty liver disease (NAFLD), now affecting both adults and children. Discover the new terms defining this condition and its alarming connections to obesity. Learn about dietary strategies, including carbohydrate restriction and the benefits of sustainable protein sources. Dive into research linking low-carb diets to improved liver health, and uncover insights from both human and animal studies on the ketogenic diet's complex role. Practical tips await for enhancing your metabolic health!

Join us for a FREE Live Q&A with Dr. Spencer Nadolsky on April 22nd at 9am PT / 12pm ET! Your first seven days are free, and as a member of The Metabolic Initiative, you’ll gain access to exclusive, ad-free episodes, hundreds of expert-led videos on metabolic health and therapy, CME opportunities, and more here!In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Spencer Nadolsky—board-certified obesity and lipid specialist, former NCAA heavyweight wrestler, and founder of Vineyard—to explore one of the most hotly debated and often misunderstood tools in modern medicine: GLP-1 receptor agonists.Together, they take a deep dive into how these drugs work, who they’re for, and why they might not always be a magic bullet. Dr. Nadolsky shares clinical insights into the real-world use of semaglutide, tirzepatide, and combination therapies, breaking down everything from appetite regulation and side effects to muscle loss, mood changes, and the potential future of prevention.They also tackle pediatric obesity, long-term use vs. off-ramping, and the critical role of resistance training and nutrition for protecting muscle mass while on these medications.Special thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here✅ Fatty15 – Get 15% off a 90-day Starter Kit here (use code METABOLICLINK)✅ Zocdoc – Find and instantly book a top-rated doctor here✅ Puori – Get 20% off supplements with code METABOLICLINK here🧠 Learn more about Dr. Nadolsky → drspencer.com💥 Don’t forget to RSVP for the live Q&A on April 22!🎟️ membership.metabolicinitiative.com/drspencerIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Dr. Philip Ovadia, a renowned cardiac surgeon and founder of Ovadia Heart Health, dives into the crucial link between metabolic health and heart disease prevention. He challenges the traditional focus on cholesterol, advocating for a greater emphasis on insulin resistance and inflammation. Ovadia emphasizes the power of lifestyle changes and advanced testing, like Coronary Artery Calcium Score scans, to proactively manage heart health. His journey from obesity to wellness fuels a passionate call for a holistic approach, reshaping our understanding of heart disease.

Dr. Ana Andreazza, a Professor at the University of Toronto and an expert in mitochondrial function, discusses the revolutionary connections between mitochondria and mental health. She highlights her pioneering research on mitochondrial dysfunction in psychiatric disorders, particularly bipolar disorder. Delving into innovative models like 3D brain organoids, she reveals how mitochondrial health impacts mood and metabolism. The conversation also covers potential treatments, including mitochondrial transplantation and the role of substances like metformin and C15 fatty acids.

In this engaging discussion, Amanda Decker, a nurse practitioner specializing in weight management, and Ben Bikman, an expert on GLP-1 therapy, delve into optimizing metabolic health. They explore the long-term effects of GLP-1 medications on fat and muscle, challenging traditional views on dieting and metabolism. The conversation also addresses the impact of diet and exercise on nerve function and lipid profiles. Listeners will gain insights into the myths surrounding high-protein diets and the crucial role of the microbiome in weight management.

What if we could target cancer at its metabolic core? In this episode of The Metabolic Link, Dr. Dominic D’Agostino is joined by Dr. Tomás Duraj, a physician and cancer metabolism researcher working alongside Dr. Thomas Seyfried.Dr. Duraj is the lead author of a groundbreaking review on ketogenic metabolic therapy for glioblastoma, bringing together leading experts to explore how metabolic strategies could reshape cancer treatment.In this deep-dive conversation, they discuss the bioenergetics of cancer, the role of mitochondria, the Warburg effect, and why targeting glucose and glutamine metabolism may be the key to making standard cancer therapies more effective.Whether you’re a researcher, clinician, or someone interested in the latest advancements in cancer therapy, this episode is packed with insights that could redefine the way we think about cancer treatment. Watch the full episode here or listen on your favorite podcast player for this must-hear discussion on the future of metabolic therapy for cancer!Read Dr. Duraj's paper: Clinical research framework proposal for ketogenic metabolic therapy in glioblastomaAbout Dr. Tomás DurajDr. Tomás Duraj is a Czech physician-scientist, receiving his Medical Degree from the Rey Juan Carlos University and his PhD in Translational Medicine from the CEU San Pablo University (Madrid, Spain). His research focuses on studying the potential of bioenergetic modulation in cancer metabolism, with special emphasis on glioblastoma, the most aggressive and lethal primary brain tumor. After developing cancer research at the team of Dr. Ayuso Sacido, he joined Dr. Thomas N. Seyfried’s laboratory in Boston College. His goal is to advance our understanding of metabolic oncology on a rigorous, evidence-based background, making it part of the standard oncology toolkit.Special thanks to the sponsors of this episode:Puori: Get 20% off Puori supplements at https://puori.com/METABOLICLINK and use the code METABOLICLINKFatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/METABOLICLINK and use code METABOLICLINK.MUDWTR: Get up to 43% off with code METABOLICLINK at https://mudwtr.com/METABOLICLINKIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.