The Metabolic Impact of GLP-1s on Obesity | Spencer Nadolsky, DO | Ep.65

Apr 11, 2025

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ANECDOTE

Patient Satiety with GLP-1s

Dr. Spencer Nadolsky shares patients describing GLP-1 agonists as providing satiety unlike anything else they've experienced.
They feel like people without weight struggles experience this natural lack of food craving.

INSIGHT

GLP-1 Reduces Appetite, Not Metabolism

GLP-1 agonists work primarily by reducing caloric intake, not by increasing metabolic rate.
Upcoming drugs combining GLP-1 and glucagon receptors may actually increase metabolic rate, enhancing fat loss.

ADVICE

Combine GLP-1 with Lifestyle Changes

Use GLP-1 drugs as facilitators for behavior change, not as standalone solutions.
Combine their use with resistance training and higher protein diets to minimize muscle loss and enhance outcomes.

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Join us for a FREE Live Q&A with Dr. Spencer Nadolsky on April 22nd at 9am PT / 12pm ET! Your first seven days are free, and as a member of The Metabolic Initiative, you’ll gain access to exclusive, ad-free episodes, hundreds of expert-led videos on metabolic health and therapy, CME opportunities, and more here!

In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Spencer Nadolsky—board-certified obesity and lipid specialist, former NCAA heavyweight wrestler, and founder of Vineyard—to explore one of the most hotly debated and often misunderstood tools in modern medicine: GLP-1 receptor agonists.

Together, they take a deep dive into how these drugs work, who they’re for, and why they might not always be a magic bullet. Dr. Nadolsky shares clinical insights into the real-world use of semaglutide, tirzepatide, and combination therapies, breaking down everything from appetite regulation and side effects to muscle loss, mood changes, and the potential future of prevention.

They also tackle pediatric obesity, long-term use vs. off-ramping, and the critical role of resistance training and nutrition for protecting muscle mass while on these medications.

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🧠 Learn more about Dr. Nadolsky → drspencer.com

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