In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.The hosts unpack these findings, discussing the potential mechanisms behind the divergent immune signatures, the limitations of the short-term study design, and the need for further research.They also highlight the importance of carefully standardizing the macronutrient and micronutrient compositions of the dietary interventions to isolate the key drivers of the observed changes.Overall, this episode provides a thought-provoking look at the profound impacts that diet can have on the functioning of our immune system, setting the stage for future studies exploring the therapeutic potential of nutritional approaches.This episode is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at https://gdx.net/themetaboliclinkAs mentioned in the introduction, you can watch the free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

The following Metabolic Link episode was originally filmed at Metabolic Health Summit 2024 and we're excited to share it with you today in its entirety! In this presentation, Dr. Andy Galpin, a human performance scientist, shares his insights on utilizing scientific principles, specifically the 'Biomolecular Athlete' concept, to achieve athletic excellence. He emphasizes the importance of individualized strategies that consider sleep, diet, stress, respiratory rates, and blood chemistry.The discussion then progresses to the groundbreaking future of human performance, including the use of digital twins for simulating and optimizing individual health outcomes, and the exploration of advanced technologies such as in-mouth sensors, full-body MRI, shoe sole force plates, and markerless motion capture.Case studies are presented to illustrate the successful application of these innovative approaches, showcasing the potential for precision and customization in coaching for optimal health and performance.This talk is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at gdx.net/themetaboliclinkAs mentioned in the introduction, you can watch this free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Professor Jeff Volek discusses the impact of ketogenic diets on muscle glycogen, heart function, and military resilience. Talks include muscle production of ketones, diabetic complications, and the importance of educating physicians on therapeutic nutrition.

This week's episode of The Metabolic Link features a full presentation from Metabolic Health Summit 2024. Dr. Ben Bikman, professor at Brigham Young University, dives deep into the intricacies of fat and its relationship to metabolic health.This is the full presentation he delivered at Metabolic Health Summit 2024 in Clearwater Beach, Florida. In it he shares his expertise on the link between body fat, insulin resistance, and chronic diseases such as obesity and diabetes. Throughout this talk, he covers:💡 The role of insulin in regulating obesity and diabetes, and its direct correlation with maintaining fat mass.💡 Understanding the concept of the personal fat threshold and how it differs among individuals, leading to insulin resistance when exceeded.💡 Why studying weight gain provides crucial insights into the mechanisms of obesity, rather than merely focusing on weight loss.💡 The paradox of hyperplasia and its unexpected role in improving insulin sensitivity.💡 How exercise influences fat cell behavior through hormonal signals, particularly insulin.If you enjoy this episode, it is just one of 30 fascinating presentations captured at Metabolic Health Summit 2024. You can still get on-demand access and watch all the action just like you were there in-person. But the doors close on February 29th! Go to metabolichealthsummit.com to get your virtual pass now.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Dr. Georgia Ede, Harvard-trained psychiatrist specializing in nutrition science and brain metabolism, discusses implementing a therapeutic ketogenic diet, the critical role of ketones in brain health, the lack of nutrition education in medical training, and Alzheimer's disease as a metabolic disorder.

Recap of Metabolic Health Summit 2024 with Dr. D'Agostino and Dr. Poff, discussing fasting diets, metabolic therapies, exercise importance, ketogenic diets, and functional sweeteners. Highlights include groundbreaking liver cell ketone consumption research and the value of virtual summit attendance for optimizing metabolic health.

We’ve just launched an extra and exciting episode of The Metabolic Link podcast! It features an eye-opening conversation between our host Dominic D’Agostino PhD, and guests Dave Feldman and Dr. Nick Norwitz, two researchers and MHS 2024 speakers spearheading investigations into the lean mass hyperresponder (LMHR) phenotype.Dave Feldman is a software engineer who became deeply interested in lipidology after seeing his cholesterol spike on a low-carb, high-fat diet. He has since performed self-experiments and published several papers on the possible mechanisms behind LMHR. He is currently conducting a clinical study out of UCLA through his newly formed public charity, the Citizen Science Foundation.Nicholas Norwitz completed his PhD at the University of Oxford and his thesis focused on ketone metabolism and neurodegenerative diseases. He is currently a medical student at Harvard Medical School.In this episode Dave, Dr. Norwitz, and Dr. D'Agostino dive into…The debate around whether saturated fat drives increased LDL levels, especially in the LMHR phenotype.The "Lipid Energy Model" hypothesizing a metabolic/physiological process underlying LMHR phenotype. Concerns about erroneously grouping lean mass hyperresponders with familial hypercholesterolemia patients. The importance of separating discussions of underlying mechanism from clinical recommendations.Their vision for the future direction of LMHR research and public education on this topic.Be sure to secure your spot at MHS 2024 in Clearwater Beach, Florida, where Dave and Nick will be presenting their latest research! Both virtual and in-person seats are still available at metabolichealthsummit.com.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dominic D’Agostino and Dr. Jonathan Jun, a pulmonary critical care and sleep medicine physician at Johns Hopkins.He is an expert in the diagnosis and treatment of sleep-disordered breathing, and in the care of critically ill patients in the Medical ICU. He is a member of the Sleep Fellowship Program Evaluation and Clinical Competency Committee and provides teaching to medical students and residents at Johns Hopkins.In this episode, we cover:💡 Defining obesity hypoventilation syndrome (OHS) and its overlap with sleep apnea💡 Assessing CO2 retention and implementing non-invasive ventilation💡 The role of dramatic weight loss in treating OHS💡 Using ketogenic diets to lower CO2 levels and improve sleep apnea💡 Developing pharmacological options for OHS and sleep disordered breathing💡 Studying the impacts of exogenous ketones ingestion prior to sleepBe sure to secure your spot at MHS 2024 in Clearwater Beach, Florida as Dr. Jun will be joining us to present more of his research! CMEs and CPEUs available. Virtual registration is also an option for those who can’t join us in person! Go to metabolichealthsummit.com to learn more.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Discover the metabolic wonders of allulose, a low-calorie sweetener that supports insulin sensitivity and aids weight management. The hosts highlight how allulose might revolutionize dietary approaches for diabetes and metabolic disorders. They dive into the alarming links between fructose and cancer progression, discussing how high fructose intake fuels tumors and triggers obesity-related risks. The conversation emphasizes dietary fructose restriction as a potential anti-cancer measure, all while underscoring the need for further research in these critical areas.

Entrepreneur Chad Vanags shares his journey of becoming metabolically, physically, and mentally elite to heal from cancer. They discuss the stress-health connection, the motivation gap in cancer patients, and navigating a diagnosis with mental resilience. They also touch on the role of nutrition and mindset in mental health, as well as overcoming fear and transitioning to a new venture.