
The Metabolic Link
Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This is where science meets society.
Latest episodes

Jul 16, 2024 • 58min
Metabolic Therapy for Serious Mental Illness | Dr. Deanna Kelly, Pharm.D., BCPP | The Metabolic Link Ep.45
Dr. Deanna Kelly discusses metabolic therapies for mental illness, including the use of ketogenic diet for schizophrenia. They explore the impact of diet on mental health, metabolic dysfunction in mental illness, personalized medicine, and challenges in implementing metabolic therapy.

Jul 2, 2024 • 57min
Dr. Robert Lustig | Obesogens: The Hidden Driver of Obesity | The Metabolic Link Ep. 44
Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of the Metabolic Link Podcast, host Dr. Dom D'Agostino sits down with Dr. Robert Lustig to discuss groundbreaking research unifying different models of obesity. They dive deep into the flaws of the traditional energy balance and carbohydrate-insulin models and introduce a compelling integrative theory encompassing the impact of obesogens, redox biology, and reactive oxygen species (ROS) on metabolic health. The conversation navigates through a review article by Dr. Lustig and others on obesogens from the International Journal of Obesity, dissecting specific obesogens like bisphenol A, phthalates, and glyphosate, and examining how different foods and lifestyle choices can mitigate their effects. This episode is a must-listen for anyone interested in nutritional science, metabolic health, and the future of obesity research.About Dr. LustigRobert H. Lustig, M.D., M.S.L. is Emeritus Professor of Pediatrics in the Division of Endocrinology, and Member of the Institute for Health Policy Studies at UCSF. Dr. Lustig is a neuroendocrinologist, with expertise in metabolism, obesity, and nutrition.To learn more about Dr. Lustig, please visit: https://robertlustig.comSpecial thanks to our sponsors:Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclinkLMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at https://drinklmnt.com/metaboliclinkAquaTru is a reverse osmosis water purifier that uses a 4-stage purification process. Their countertop purifiers work with NO installation and remove 83 dangerous contaminents. Get 20% OFF any AquaTru purifier by using the code METABOLICLINK at AquaTru.comReferenced Papers:Obesogens: a unifying theory for the global rise in obesityDo We Need a New Unifying Theory for Obesity?In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Jun 18, 2024 • 1h 16min
Take Control of Your Metabolic Health with Dr. Casey Means | The Metabolic Link Ep. 43
Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this interview, host Victoria Field sits down with Dr. Casey Means, a Stanford-trained physician, entrepreneur, and New York Times bestselling author of the new book Good Energy. Dr. Means shares her inspiring journey from being a head and neck surgeon to leaving traditional medicine and becoming a leading voice in the metabolic health field. They take a deep dive into the environmental factors that impact our metabolism, the importance of taking care of your mitochondria, and practical steps to improve your overall metabolic health and well-being. Dr. Means also shares her own health struggles along the way and even sheds light on the emotional aspects of metabolic health, including the importance of navigating through trauma and making peace with death. Tune in for a conversation that is both informative and deeply personal.Casey Means, MD is a Stanford-trained physician and co-founder of Levels, a health technology company with the mission of reversing the world’s metabolic health crisis and author of the #1 New York Times bestselling book Good Energy, released May 2024. She received her BA with honors and MD from Stanford, was President of her Stanford class, and has served on Stanford faculty. She trained in Head & Neck Surgery before leaving traditional medicine to devote her life to tackling the root cause of why Americans are sick. She has been featured in The New York Times, The New Yorker, The Wall Street Journal, Forbes, Women’s Health, and more. To learn more about Dr. Means, to join her newsletter, and get her book, please visit: https://www.caseymeans.com/Special thanks to our sponsors:Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclinkLMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at https://drinklmnt.com/metaboliclink AirDoctor is an air purifier that filters out 99.99% of dangerous contaminants so your lungs don’t have to. Visit airdoctorpro.com and used promo code METABOLIC LINK to get UP TO $300 off select air purifiers! You will also receive a free 3 year warranty on any unit, which is an additional $84 value!In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Jun 4, 2024 • 22min
Lily Nichols, RDN, CDE | Optimizing Pregnancy and Metabolic Health | The Metabolic Link Ep.42
Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs! Registered dietitian, Lily Nichols, RDN, CDE, is back on The Metabolic Link, this time in an intimate interview that dives into the critical links between metabolic health, perinatal nutrition, and long-term wellbeing. This episode dives deep into how nutrition during the childbearing years can affect not only mothers but their children throughout their lives.Lily, who is also a New York Times bestselling author of key books on prenatal nutrition, unpacks the significance of blood sugar balance, the role of various micronutrients, and the timing and composition of meals in optimizing fertility and pregnancy health. She shares her expertise on managing gestational diabetes through dietary adjustments and explains how both maternal and paternal health can influence pregnancy outcomes. Additionally, the conversation includes discussions around fertility treatments and assisted reproductive technologies.About Lily Nichols, RDN, CDE:Lily Nichols is a Registered Dietitian/Nutritionist, Certified Diabetes Educator, researcher, and author with a passion for evidence-based nutrition. She is the founder of the Institute for Prenatal Nutrition®, co-founder of the Women’s Health Nutrition Academy, and the author of three books: Real Food for Fertility, Real Food for Pregnancy, and Real Food for Gestational Diabetes.We're hosting a Live Q&A with Lily Nichols as a follow up to this episode on June 12th at 8am PT/11am ET! Bring your questions and join our medical education platform with a FREE 7-day free trial. Click here to register. Special thanks to our sponsors:Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclink LMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at https://drinklmnt.com/metaboliclinkTimeline, a Swiss based life science company, is a global leader in Urolithin A research. Timeline is offering 10% off your first order of Mitopure. Go to timeline.com/METABOLICLINK & use code METABOLICLINKIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

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May 21, 2024 • 53min
Mitochondrial Health and Urolithin A with Dr. Anurag Singh | The Metabolic Link Ep. 41
Dr. Anurag Singh, CMO of Timeline, discusses Urolithin A's impact on mitochondrial health, muscle strength, and inflammation. They explore mitophagy, synergistic effects with ketones, and transdermal delivery systems. Urolithin A's potential in combatting age-related decline and future applications is also highlighted.

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May 7, 2024 • 1h 8min
Dr. Nina Teicholz | Beyond the Diet Wars: A Deep Dive into Nutrition Science | The Metabolic Link Ep.40
Become a member of The Metabolic Initiative for exclusive episodes and earn CMEs! Dive into the core of nutrition science with Dr. Dominic D'Agostino and Dr. Nina Teicholz, and uncover the remarkable benefits of saturated fats, unravel the complexities of LDL cholesterol, and dig into the heated debate surrounding food addiction and ethical meat consumption. Dr. Teicholz sheds light on the misunderstood facets of dietary fats, debunking prevalent myths about cholesterol, highlighting potential detrimental effects of seed oils, and offering profound insights into how adherence to outdated dietary guidelines impacts both our health and the environment. Bring your follow up questions on May 16th at 1pm PT/4pm ET to our Live Q&A with Dr. Teicholz on our medical education platform, The Metabolic Initiative. Your first 7 days on the platform are free! Visit this link to register. To access Dr. Sarah Hallberg's legacy course, please click here. More info on Dr. Teicholz and her latest articles, click here. Thank you to our sponsors of this episode: Genova Connect, powered by Genova Diagnostics offers advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Receive 15% off any of their tests with code metaboliclink: https://gdx.net/themetaboliclink LMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at: https://drinkLMNT.com/MetabolicLink In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Apr 23, 2024 • 55min
A Biological Switch that Drives Obesity, Diabetes, and Dementia with Richard Johnson, MD | The Metabolic Link Ep. 39
Become a member of The Metabolic Initiative for exclusive episodes and to earn CMEsIn this episode, recorded at Metabolic Health Summit 2024, Dr. Richard Johnson dives into the groundbreaking research that has uncovered the central role of fructose in driving the epidemics of obesity, diabetes, and a wide range of other metabolic diseases.Dr. Johnson presents compelling evidence that fructose, a seemingly innocuous sugar, is in fact a key trigger for activating a powerful biological survival switch. This switch, evolved in nature to help animals prepare for times of scarcity, is now being inadvertently activated in humans by our modern high-carbohydrate, high-sugar diets.Through detailed scientific explanation and insightful case studies, Dr. Johnson illuminates how fructose's unique metabolic effects - including its ability to lower ATP levels, induce leptin resistance, and promote fat storage - are the driving forces behind the rise of metabolic syndrome and its associated conditions.Equally important, Dr. Johnson offers practical dietary recommendations and strategies to help individuals navigate this complex landscape, emphasizing the importance of reducing sugar, refined carbs, and processed foods, while embracing a low-carb, nutrient-dense approach.This eye-opening episode is a must-listen for anyone seeking to understand the root causes of the metabolic health crisis and learn evidence-based solutions to reclaim their wellbeing.Special thanks to our sponsors:Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Receive 15% off any of their tests with code metaboliclink: http://gdx.net/themetaboliclink LMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at: drinkLMNT.com/MetabolicLink In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Apr 9, 2024 • 51min
Journal Club: Exploring Immune Response to Diet: Vegan vs Ketogenic Ep. 38
In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.The hosts unpack these findings, discussing the potential mechanisms behind the divergent immune signatures, the limitations of the short-term study design, and the need for further research.They also highlight the importance of carefully standardizing the macronutrient and micronutrient compositions of the dietary interventions to isolate the key drivers of the observed changes.Overall, this episode provides a thought-provoking look at the profound impacts that diet can have on the functioning of our immune system, setting the stage for future studies exploring the therapeutic potential of nutritional approaches.This episode is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at https://gdx.net/themetaboliclinkAs mentioned in the introduction, you can watch the free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Mar 26, 2024 • 1h 29min
BioMolecular Athlete: Advanced Tools For Enhanced Human Performance with Andy Galpin, PhD | The Metabolic Link Ep. 37
The following Metabolic Link episode was originally filmed at Metabolic Health Summit 2024 and we're excited to share it with you today in its entirety! In this presentation, Dr. Andy Galpin, a human performance scientist, shares his insights on utilizing scientific principles, specifically the 'Biomolecular Athlete' concept, to achieve athletic excellence. He emphasizes the importance of individualized strategies that consider sleep, diet, stress, respiratory rates, and blood chemistry.The discussion then progresses to the groundbreaking future of human performance, including the use of digital twins for simulating and optimizing individual health outcomes, and the exploration of advanced technologies such as in-mouth sensors, full-body MRI, shoe sole force plates, and markerless motion capture.Case studies are presented to illustrate the successful application of these innovative approaches, showcasing the potential for precision and customization in coaching for optimal health and performance.This talk is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at gdx.net/themetaboliclinkAs mentioned in the introduction, you can watch this free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Mar 4, 2024 • 23min
Ketogenic Diet’s Impact on Health and Performance with Jeff Volek, PhD | The Metabolic Link Ep. 36
Professor Jeff Volek discusses the impact of ketogenic diets on muscle glycogen, heart function, and military resilience. Talks include muscle production of ketones, diabetic complications, and the importance of educating physicians on therapeutic nutrition.
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