Oncotarget

Researchers discuss the role of MALAT1 in regulating gene and protein expression in the MAPK pathway in melanoma. Antisense oligonucleotide treatment decreases BRAF levels and MALAT1 shows increased correlation with MAPK genes in patient samples. Potential therapeutic advances in MAPK pathway regulation.

The podcast delves into the intriguing role of the creatine shuttle in cancer metabolism, specifically its potential in tackling colorectal cancer. Researchers explore how inhibiting creatine kinase B and mitochondrial creatine kinase can suppress growth, stemness, and metastasis in colorectal cancer cells, offering a promising therapeutic strategy.

Dr. Gopal C. Kundu from KIIT Deemed to be University in Odisha, India, discusses the molecular dialogue between tumor cells and fibroblasts. They delve into topics such as the role of cancer-associated fibroblasts in tumor growth, the transformation of fibroblasts into myofibroblasts, and proposing a combined therapy strategy to target osteopontin signaling in both fibroblasts and cancer cells to combat chemoresistance.

Explore the significance of HER3 as a survival pathway in metastatic colorectal and pancreatic cancer. Researchers discuss its role in chemo-resistance and cancer cell growth, along with challenges in translating preclinical findings to clinical impact. Strategies for HER3 targeted therapies are proposed to combat resistance mechanisms.

Research paper published in Oncotarget's Volume 14 reveals the role of GPR141 in breast cancer progression by regulating oncogenic mediators and the p-mTOR/p53 axis. GPCRs are hot-spot targets in cancer research. Increased GPR141 expression enhances migratory behavior of breast cancer cells and drives oncogenic pathways through EMT and p-mTOR/p53 signaling.

Researcher Enyuan S discusses targeting cellular respiration in glioblastoma, highlighting the impact of HDAC-inhibitors on metabolism and the potential synergistic effect with imipridones. The importance of mitochondrial metabolism and glycolysis in malignancies, particularly glioblastoma, is also explored.

Explore the themes of transformation and trust in scholarly publishing with Impact Journals at the SSP 45th Annual Meeting. Join them at Booth 216 to learn about their focus on rapid dissemination of scientific discoveries in cancer and aging research.

Researchers developed an automated reporting process for NGS-based clonality testing to classify B and T cell results more accurately. The model increases sensitivity in detecting clonality, aiding in diagnosing and monitoring lymphoproliferative disorders.

Researchers discuss a groundbreaking method of opening the blood-brain barrier using intra-arterial injection to deliver drugs to treat brain cancers and neurological disorders. The protective role of the BBB, challenges in drug delivery, and potential benefits of the new approach are explored. Experiments in mice show promising results, with a focus on enhancing outcomes for brain tumor patients.

Researchers in cancer proteomics discuss utilizing gene candidates from mass-spectrometry-based data to target therapy, focusing on protein kinases in uterine endometrial cancer. They highlight the importance of public data portals for cancer research and leveraging multiomics data for drug discovery.