Oncotarget

Researchers discuss the mechanism behind MCL-1 inhibitors, aiming to understand MCL-1 protein stability in cancer cells. The team explores the development of next-generation MCL-1 inhibitors for effective cancer treatment.

Exploration of Diphenyl ditelluride's anticancer activity in human colon cancer cells, including its ability to induce cell cycle arrest, DNA strand breaks, and form covalent complexes with DNA for potential anti-proliferative treatment.

Researchers Diwakar Davar and Roberta Zappasodi discuss the potential of GITR in cancer immunotherapy, its expression on immune cells, preclinical successes, challenges in clinical translation, and understanding immune responses for novel treatments.

Researchers conducted a study on using Metformin to prevent Metabolic Syndrome during Androgen Deprivation Therapy for advanced prostate cancer. The results showed no reduction in the risk of ADT-related Metabolic Syndrome or significant changes in PSA response.

Explore the history and impact of the Ride for Roswell charity bike ride event in Buffalo, NY. Learn about the significant contributions towards cancer research and patient care. Discover the fundraising rewards and team sponsorships available for the 2023 event, including support from scientific journals OncoTarget and Aging.

The podcast explores the role of ACSL4 in quadruple negative breast cancer as a potential biomarker, treatment predictor, and therapeutic target. ACSL4 is a lipid metabolic enzyme differentially expressed in breast tumors, with highest expression in mesenchymal and basal-like subtypes. Researcher Marie E. Monaco discusses the potential of utilizing ACSL4 status for predicting response to treatment regimens.

Researchers discuss the novel small molecule LP-284's effectiveness in targeting non-Hodgkin's lymphoma by inducing repair of DNA damage, potentially offering a promising treatment option for refractory NHL cases.

Researchers Betlem Mezquita, Marjorie Reyes-Farias, and Miquel Pons discuss targeting the Src N-terminal regulatory element in cancer. They explore why specific inhibition of Src is crucial for effective cancer treatment and highlight the significance of the SNRE region in cancer progression and potential therapeutic implications.

Exploring the value of chemotherapy after immunotherapy for advanced lung cancer treatment. Discussing the efficacy of DASA Taxil and its impact on patients. Highlighting the evolving treatment landscape and importance of considering chemotherapy in advanced lung cancer cases.

Researchers discuss the connection between BORIS gene mutations and breast cancer progression, revealing frequent mutations and heightened protein expression in breast carcinoma cases