Oncotarget

Researchers discuss the therapeutic potential of FAAH inhibition and endocannabinoids for breast cancer treatment, specifically exploring the effects on cancer cell viability and apoptosis.

Laura Ga, a researcher studying the function of Neutrophil PAD4 in cancer beyond promoting NETosis, discusses the role of myeloid-derived suppressor cells (MDSC) in cancer growth. She explains how tumor-infiltrating PMN-MDSCs suppress immune responses and the potential of targeting PAD4 for inhibiting tumor progression.

Guest Prabin Dhangada Majhi discusses the role of genetic modifiers of p53 in breast cancer therapies. They highlight the prevalence of TP53 mutations in tumors, its significance as a barrier to oncogenic transformation, and the vulnerability of breast epithelium. Also mentioned are the potential contributions of over 300 polymorphisms in breast cancer risk.

This podcast explores the role of apoptotic cells in driving cell death in hair follicles during their regression cycle. The researchers conducted intervital microscopic studies on live mice and discovered that the elimination of epithelial cells involves super basal cell differentiation and basal cell apoptosis. They proposed a mathematical model to describe the regression cycle and suggest that apoptotic cells induce apoptosis in neighboring cells.

Researchers discuss the role of metabolic enzyme GLS2 in regulating cell death (ferroptosis) in liver cancer cells, highlighting the potential for targeted therapies and immunotherapies. GLS2's clinical relevance and therapeutic potential for hepatocellular carcinoma are explored.

Researchers from Columbia University discuss the role of GLS2 in inducing ferroptosis and its potential therapeutic implications for liver diseases. They explore its relationship with p53 and SLC7A11 and highlight a recent study validating GLS2's promotion of ferroptosis in mouse models.

Researchers discuss the role of nuclear morphology in breast cancer metastasis and the importance of immunofluorescence staining. They explore the physical barriers faced by cancer cells during metastasis and highlight the correlation between aemarin expression and survival time in breast cancer patients.

This podcast discusses the challenges of temozolomide treatment for glioblastoma and the role of the GBP3-STING interaction in the development and recurrence of this tumor. It explores the impact of GBP3 upregulation on temozolomide response, which is associated with worse survival outcomes.

Dr. Omkar Desai discusses the significance of HER3 in promoting cancer cell growth and chemo resistance. Challenges in translating preclinical studies on HER3 targeted therapies to clinical trials and HER3 overactivation as a resistance mechanism in cancer cells are explored. Emphasizing the importance of identifying HER3 expression and gene fusions as predictive biomarkers and developing combination therapies to combat resistance.

Researchers explore the role of cancer stemness in drug resistance of colorectal cancer cells. They found that a triple combination treatment against BRAF, EGFR, and MEK significantly reduced stemness and oncogenic signaling pathways in these cells.