Hepatocellular carcinoma (HCC) is the most common type of liver cancer. It is particularly challenging to treat because HCC is often diagnosed in late stage and resistant to chemotherapy and radiation. However, advancements in targeted therapies and immunotherapies have opened new avenues for the treatment of this aggressive disease.
In a new editorial paper, researchers Sawako Suzuki, Divya Venkatesh, Tomoaki Tanaka, and Carol Prives from Columbia University highlight the role of a metabolic enzyme known as glutamine synthase 2 (GLS2) in regulating ferroptosis in HCC. Ferroptosis is a form of cell death that involves iron-dependent accumulation of lipid peroxides. On October 19, 2023, their editorial was published in Oncotarget, entitled, “GLS2 shapes ferroptosis in hepatocellular carcinoma.”
Full blog - https://www.oncotarget.org/2023/10/19/how-a-metabolic-enzyme-can-trigger-cell-death-in-liver-cancer-cells/
Paper DOI - https://doi.org/10.18632/oncotarget.28526
Correspondence to - Carol Prives - clp3@columbia.edu
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Keywords - cancer, ferroptosis, hepatocellular carcinoma, GLS2, p53, tumor suppression
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