Oncotarget
How a Metabolic Enzyme Can Trigger Cell Death in Liver Cancer Cells
Oct 20, 2023
Researchers discuss the role of metabolic enzyme GLS2 in regulating cell death (ferroptosis) in liver cancer cells, highlighting the potential for targeted therapies and immunotherapies. GLS2's clinical relevance and therapeutic potential for hepatocellular carcinoma are explored.
05:02
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Quick takeaways
- GLS II promotes feroptosis in hepatosellular carcinoma (HCC) by enhancing lipid-reactive oxygen species (ROS) generation, suggesting it as a potential therapeutic target for HCC.
- Downregulation of GLS II expression in human HCC samples correlates with poor prognosis and reduced sensitivity to feroptosis-inducing agents, highlighting GLS II as a potential target for enhancing the efficacy of feroptosis-based therapies.
Deep dives
GLS II's role in regulating feroptosis in HCC
Researchers highlight the role of GLS II, a metabolic enzyme, in regulating feroptosis in hepatosellular carcinoma (HCC). GLS II promotes feroptosis in HCC by catalyzing glutamine to glutamate, and then enhancing lipid-reactive oxygen species (ROS) generation. GLS II deficiency leads to increased HCC tumor genesis and resistance to feroptosis, while over-expression of GLS II reduces tumor growth and sensitizes cancer cells to feroptosis. These findings suggest that GLS II is a potential therapeutic target for HCC and could enhance the efficacy of feroptosis-based therapies.
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