Oncotarget cover image

Oncotarget

Suppression of Cancer Stemness & Drug Resistance via BRAF/EGFR/MEK Inhibition in Colorectal Cancer

Oct 11, 2023
Researchers explore the role of cancer stemness in drug resistance of colorectal cancer cells. They found that a triple combination treatment against BRAF, EGFR, and MEK significantly reduced stemness and oncogenic signaling pathways in these cells.
02:51

Podcast summary created with Snipd AI

Quick takeaways

  • A triple combination treatment targeting BRAF, EGFR, and MEK significantly reduced stemness and oncogenic signaling pathways in colorectal cancer cells.
  • Understanding drug resistance mechanisms in patient-derived cancer cells and developing effective treatments shows promise for cancer precision medicine.

Deep dives

Targeting Cancer Stem Cells and Resistance Mechanisms in Colorectal Cancer

Researchers conducted a study to investigate the role of cancer stem cells (CSCs) and drug resistance in colorectal cancer cells. They developed cultures of patient-derived tumor cells and analyzed the effects of inhibiting the MAPK pathway. The study found that targeted therapies enriched the expression of CSC markers and activated the PI3K/AKT pathway. However, a triple combination treatment targeting BRAF, EGFR, and MEK significantly reduced stemness and oncogenic signaling pathways. This research demonstrates the potential to overcome stemness-mediated drug resistance in colorectal cancer.

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode