Oncotarget
Subpopulations of AIB1-Expressing Breast Cancer Cells Enable Invasion and Metastasis
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Quick takeaways
- Genetic and epigenetic events drive individual breast cancer cells to proliferate and expand, leading to a heterogeneous mixture of cells that can invade blood vessels and spread as metastatic seeds.
- A subclonal population of cells within a heterogeneous tumor has the ability to significantly alter the growth characteristics, invasiveness, and metastasis of the entire tumor through cell-cell crosstalk, challenging the notion that organ metastasis is solely determined by the cancer cell seed and target organ soil.
Deep dives
Breast cancer invasion and metastasis: Understanding sub-populations of AIB-1 ISA form expressing cells
Researchers from Georgetown University Medical Center discuss the potential mechanisms of breast cancer invasion and metastasis in a new editorial paper. They explain that genetic and epigenetic events drive individual tumor cells to proliferate and expand, resulting in a heterogeneous mixture of cells that can evade immune surveillance and acquire the ability to invade blood vessels and spread as metastatic seeds to distant sites. This research challenges the concept that organ metastasis is solely determined by the selected cancer cell seed and the appropriate soil of the target organ. Sharif et al. demonstrate that a subclonal population of cells in a heterogeneous tumor can significantly alter the growth characteristics, invasiveness, and metastasis of the entire tumor through cell-cell crosstalk. They highlight the role of an alternative splice isoform of the transcriptional co-regulator and oncogene AIB1, which leads to increased tumor growth and invasion in a small subpopulation of cells.
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