Oncotarget
Adopted Neoplastic Cells and the Consequences of Their Existence
Aug 29, 2023
Research perspective discusses adopted neoplastic cells in tumors, where normal cells mimic neoplastic traits without genetic changes. Implications for cancer research and need for experimental studies are highlighted.
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Quick takeaways
- Some normal migratory cells can adopt the phenotype of neoplastic cells without acquiring their genome, becoming adopted neoplastic cells.
- The presence of adopted neoplastic cells challenges the traditional view that each neoplastic cell in a tumor is a genetic offspring of another neoplastic cell.
Deep dives
Adopted Neoplastic Cells in Tumors
Some normal migratory cells adopt the phenotype of Neoplastic Cells without acquiring their genome, becoming adopted Neoplastic Cells. This discovery challenges the traditional view that each Neoplastic Cell in a tumor is a genetic offspring of another Neoplastic Cell. The research perspective discusses the evidence for these adopted Neoplastic Cells, their consequences, and the types of cells that can be adopted, along with the experimental systems needed for further testing.
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