Longevity Optimization with Kayla Barnes-Lentz

What if aging wasn’t just something that happens to us, but something science could actually slow down? That’s the question at the heart of today’s conversation with Dr. Matt Kaeberlein, who’s a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer’s to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you’re curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium’s Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest’s socials + websiteYouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

What if aging wasn’t just something that happens to us, but something science could actually slow down? That’s the question at the heart of today’s conversation with Dr. Matt Kaeberlein, who’s a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer’s to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you’re curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters:00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium’s Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest’s socials + website:YouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Join us in this powerful episode as we sit down with Dr. Natalie Crawford, a double board-certified OB/GYN and reproductive endocrinologist. We explore her personal journey with recurrent pregnancy loss, the rising rates of infertility, and the impact of inflammation, toxins, and lifestyle on reproductive health. Discover how Dr. Crawford is reshaping fertility care and empowering women to understand their bodies, advocate for their health, and make informed choices about their future.Chapters:00:00 – Introduction02:15 – Dr. Crawford’s personal fertility journey & miscarriages07:07 – Discovering inflammation, toxins & celiac connection09:56 – Rising infertility rates & sperm count decline12:18 – Cycle tracking, wearables & hormone testing15:11 – AMH testing & why it’s controversial20:14 – Fertility testing, anatomy & semen analysis26:26 – Patient stories & whole-body fertility approach34:17 – Environmental toxins & endocrine disruptors40:09 – Egg quality, biological age & lifestyle factors46:28 – Advanced strategies: red light therapy, IVF testing, add-ons56:00 – Birth control myths & fertility impact01:04:09 – Menopause, genetics & shifting timelines01:12:01 – Fertility myths & misconceptions01:16:07 – Prenatal vitamins, folate vs. methylfolate debate01:21:18 – PCOS explained & why diagnosis matters01:28:36 – Closing thoughts, book & where to find Dr. Crawford*Dr. Natalie Crawford's Socials:*YouTube: https://www.youtube.com/@NatalieCrawfordMD/videosIG: https://www.instagram.com/nataliecrawfordmdTikTok: https://www.tiktok.com/@UCRZamIB-DWuVPJuc0bKhwzg Website: https://www.nataliecrawfordmd.com/X: https://x.com/ncrawfordmd?lang=enFacebook: https://www.facebook.com/nataliecrawfordmd/Podcast: https://podcasts.apple.com/us/podcast/as-a-woman/id1449553339*Kayla's social + website:*Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.comBecome a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/..

In this insightful conversation, Dr. Bill Rawls, a board-certified physician and bestselling author, shares his journey from traditional medicine to integrative healing after battling chronic Lyme disease. He discusses the limitations of conventional treatments and the surprising power of herbal remedies in restoring health. The talk delves into the importance of lifestyle, stress management, and the body’s natural defenses. Dr. Rawls emphasizes a deeper understanding of chronic illness and the need for personalized approaches to wellness.

In this engaging discussion, Dr. Janaye Duane, a behavioral scientist, futurist, and acclaimed author, shares her extraordinary journey from opera singing to harnessing technology for health improvement. She highlights transformative trends in biohacking, emphasizing the need for accessible health solutions and ethical technology use. The impact of COVID-19 on work dynamics and growing tools for personal growth are pivotal topics. Dr. Duane's insights on the role of AI in healthcare and the future of work prompt listeners to embrace innovation while staying grounded.

Dr. Brooke Stubbs, double board-certified in internal and lifestyle medicine, dives deep into female health pillars like inflammation and gut dysfunction. She elucidates how chronic symptoms such as fatigue and brain fog often stem from overlooked factors. The conversation uncovers the significant role of diet, sleep, and stress management, while challenging common myths about processed foods and plant-based diets. With actionable strategies, Dr. Stubbs empowers women to reclaim their health and navigate the complexities of hormonal balance and lifestyle choices.

In this conversation, I sit down with Nick to unpack the deeper science behind GLP-1s and metabolic health. We explore how compounds like Tirzepatide and GLP-1 agonists go beyond weight loss, influencing everything from cardiovascular elasticity and neuroinflammation to mood, cognition, and gut-brain signaling. We also discuss lesser-known drivers of real change, like adiponectin, MPO, and the surprising effects of statins on inflammation.But the conversation doesn’t stop with human health. We dive into the behavioral power of the microbiome, how dogs might reduce childhood allergies, and whether AI can actually translate what your pet is thinking. If you’re curious about fat loss, brain health, and the future of metabolic science, this episode offers a perspective you won’t find anywhere else.*Chapters:*0:00 – Meet Dr. Nick: From Patient to Pioneer06:50 – The Problem with "Evidence-Based Medicine"10:15 – Why Nick Left the Medical System13:10 – Can YouTube Have a Bigger Impact Than Hospitals?16:30 – What Is Metabolic Health & Why Does It Matter?19:00 – Mental Health, Depression & Metabolism24:15 – Brain Hacks That Actually Work40:00 – Improving Metabolic Flexibility Naturally46:00 – Gut-Brain Connection & Fiber Myths*Nick's Socials + Website*IG: https://www.linkedin.com/in/nicknorwitz/Youtube channel: https://www.youtube.com/channel/UCLTZUJSEulehPtF_ytFiU_AWebsite: https://www.nicknorwitz.com*Kayla's Socials + Website*Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.comBecome a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

In this conversation, Kayla and Dr. Amy Killen discuss the critical aspects of women's hormonal health, emphasizing the importance of estrogen, the impact of menopause, and the need for accurate information regarding hormone therapy. She highlights the significance of bone health, the role of lifestyle in hormonal balance, and emerging treatments that can enhance women's health. The discussion also touches on the intersection of women's health and environmental policy, as well as the evolving relationship between doctors and patients in the age of technology.Dr. Amy Killen, MD is a leading expert in anti-aging and regenerative medicine, specializing in skin rejuvenation, sexual optimization, and longevity. A former ER physician, she now focuses on cutting-edge therapies like stem cells, PRP, and exosomes to help people look and feel their best. Dr. Killen is the founder of the HOP Box, Humanout Health and a global speaker on biohacking and sexual health.Amy Substack Amy IG HumanautHopboxChapters00:00 Understanding Women's Hormonal Health02:49 The Importance of Bone Health in Women05:37 Navigating Hormone Therapy and Misinformation08:43 The Role of Hormones in Disease Prevention11:43 Testing and Monitoring Hormone Levels14:38 The Impact of Lifestyle on Hormonal Health17:37 Emerging Treatments and Technologies for Women's Health20:17 The Intersection of Women's Health and Environmental Policy23:10 The Future of Doctor-Patient Relationships26:11 Closing Thoughts on Women's Health and Longevity

In this episode, we explore the intersection of ovarian health, menopause, and AI technology with Kiran, the founder of TimelessBioTech. The conversation delves into the importance of ovarian longevity for women's health, the predictive tools being developed to forecast menopause timing, and the various interventions that can support ovarian health. Kiran shares insights on hormonal balance, the role of lifestyle factors, and the future of personalized health strategies for women. The discussion emphasizes the need for targeted solutions and the potential for AI to revolutionize women's health care.Timeless Biotech WebsiteKiran's email for investors, clinics, and companies looking to invest in or work with Timeless: Kiiran@timelessbiotech.comThis episode is brought to you by OneSkin, the longevity scientists behind the first topical peptide scientifically proven to reverse skin aging—now bringing their expertise to your scalp. If you care about aging well, you can’t ignore your hair. The health of your scalp directly impacts the strength, thickness, and lifespan of every strand. That’s why OneSkin created their new OS-01 HAIR, the first scalp serum powered by a longevity peptide designed to optimize follicle health, balance the scalp, and extend the healthspan of your hair follicles. In their clinical study, OS-01 HAIR showed significant improvements in hair density, thickness, and overall scalp health—all by targeting follicle aging at the root. I’ve been using it myself and I’m genuinely impressed. It’s lightweight, fragrance-free, and backed by science—not fluff. If you're serious about keeping your hair vibrant and resilient as you age, I highly recommend giving OneSkin's OS-01 HAIR a try. Head to oneskin.co/KAYLA  for 15% off your order. About KiranKiran Kumar is the Founder & CEO of Timeless Biotech, an early-stage ovarian longevity company that has prototyped the first-ever time-to-menopause predictor and ovarian age clock. Kiran is a Biotechnology Bioengineer from UC San Diego, and has contributed to research in ML-powered diagnostics.Kiran has worked in numerous longevity and wellness startups such as FOXO Technologies, OneSkin, and Timeline where she authored. research-backed contentKiran’s work sits at the intersection of Physiology, AI, and Longevity.Chapters00:00 Introduction to Ovarian Longevity and AI Solutions02:44 The Importance of Ovarian Health in Longevity05:38 Understanding Menopause and Ovarian Aging08:48 Predictive Tools for Menopause Timing11:32 Interventions for Ovarian Longevity14:31 The Role of Hormones in Ovarian Health17:25 Innovative Approaches to Hormonal Balance20:14 The Future of Ovarian Health Technologies22:58 Personalized Health Strategies for Women25:31 Conclusion and Future Directions

Meet my new doctor, Dr. Sara Szal Gottfried. I am so excited about our new duo! This conversation explores various topics including medical gaslighting, hormonal health, Kayla's labs including genetic testing, nutrition, inflammation, and the impact of environmental toxins. Sara and Kayla emphasize the need for personalized care and proactive health strategies for women, aiming to empower listeners with knowledge and actionable insights.Chapters00:00 Introduction to Women's Health Podcast02:53 Exploring Longevity and Women's Health05:30 The Impact of Medical Gaslighting on Women08:18 Understanding Hormonal Health and Testing11:02 Genetic Testing and Its Role in Women's Health14:02 The Importance of Nutrition and Micronutrients16:44 Addressing Inflammation and Autoimmune Concerns19:28 Toxic Burden and Environmental Exposures22:20 Strategies for Detoxification and Health Optimization25:06 Conclusion and Future TopicsMore About Sara: Dr. Sara Szal Gottfried is a New York Times bestselling author and a board-certified gynecologist known for her work in precision medicine and natural hormone balancing. She graduated from Harvard Medical School and MIT, and completed her residency at the University of California, San Francisco. She has authored several books, including "The Hormone Cure", "The Hormone Reset Diet", "Younger", and "Brain Body Diet". Dr. Gottfried focuses on helping women optimize their health through personalized approaches based on genetics, lifestyle, and environment. Sara Socials + Website IG: https://www.instagram.com/saragottfriedmd/Website: https://www.saragottfriedmd.comHer Podcast on Apple: https://podcasts.apple.com/us/podcast/treated-with-dr-sara-szal/id1799034638Subscribe to Her Podcast on Spotify: https://open.spotify.com/show/1dtiAfWhOpBEtB155MaoJ9?si=1bca702eadf644a5Kayla Socials + WebsiteInstagram:  https://www.instagram.com/kaylabarnes/TikTok:  https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.comBecome a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member