Longevity Optimization with Kayla Barnes-Lentz

Dr Karan Rajan - Gut Surgeon: STOP Probiotics (Heal Your Gut Like THIS Instead)

13 snips
Nov 27, 2025
In this discussion, Dr. Karan Rajan, a gut surgeon and medical educator, unravels the complexities of the gut microbiome. He debunks common myths about fiber and explains how it serves as essential fuel for gut bacteria. Discover his strategies for incorporating fiber into your diet, the benefits of prebiotics over probiotics, and how fasting can rejuvenate gut health. Dr. Rajan also explores differences in male and female microbiomes and offers insights on nourishing your gut through traditional diets. Tune in for practical tips and science-backed advice!
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ADVICE

Increase Fiber Gradually

  • Do gradually increase fiber instead of cutting it out when you get bloating; retrain your microbiome like building muscle.
  • Start small and slowly raise intake over months to reach higher fiber tolerance.
INSIGHT

Fiber Feeds Beneficial Metabolism

  • Fiber is the preferred fuel for gut bacteria and they ferment it into beneficial short-chain fatty acids like butyrate.
  • Butyrate nourishes the colon lining, reduces cancer risk, and stimulates GLP-1 production.
ADVICE

Favor Diverse Whole-Food Fibers

  • Do prioritize diverse plant foods and seeds to feed different bacterial species instead of relying on one cheap isolated fiber.
  • Use whole-food sources like chia, seeds, beans and oats for steady fiber variety.
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