Reason with Science

This episode is with Peter Atkins. He is a chemist and a Fellow of Lincoln College at the University of Oxford. Peter is a prolific writer of popular chemistry textbooks, including Physical Chemistry, Inorganic Chemistry, and Molecular Quantum Mechanics. Here we talk about what are the laws of nature?, fundamental constants, emergence in the universe, strong and weak emergence, multiverse and a theory of everything. Guest info: Amazon: https://www.amazon.com/Books-Peter-Atkins/s?rh=n%3A283155%2Cp_27%3APeter+Atkins Wikipedia: https://en.wikipedia.org/wiki/Peter_Atkins Episode links: Website: https://www.reasonwithscience.com/home/emergence-of-the-universe-with-peter-atkins Youtube: https://youtu.be/o14rvWAXiJk Spotify: https://open.spotify.com/episode/2YQUiJSqLSjXm6grwRKhN6?si=US1dT05USgSItcp0ybZovQ Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/emergence-of-the-universe-|-peter-atkins-|-reason-with-science-|-multiverse-|-physics/3ef09511-b6fd-4d44-84ae-59fbb5c974bb Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/ZTQyYzAzMTUtMDg4Ni00NTAyLWE0MjctOWQ3ZDM5NDQ1NGFi?sa=X&ved=0CAUQkfYCahcKEwjo-4GQ-5X8AhUAAAAAHQAAAAAQLA Follow Reason with Science: Website: https://www.reasonwithscience.com/ Youtube: https://www.youtube.com/channel/reasonwithscience Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/i d1641776894 Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw Timestamps: 00:00:00 Introduction 00:00:56 What is emergence? 00:02:30 what is the relation between emergence, Complexity and self-organisation? 00:12:42 How the universe originated? 00:31:00 understanding nothing and multiverse 00:32:07 How time emerges? 00:34:09 is nothing still evolving? 00:41:32 Evolution of humanity through time 00:51:05 what does it mean to be human? 00:52:48 how do we discover laws of nature? 00:58:32 outlaws and inlaws. 01:01:55 A grand unified theory in science 01:06:08 are fundamental constants fundamental? 01:17:11 predicting chemistry from physics 01:22:05 Increasing importance of predictions 01:26:05 what are the major questions for science of emergence? 01:29:15 can we create 'absolutely nothing' in the lab? 01:30:14 how much can we account for abstract properties? 01:34:30 future work 01:36:42 Thank you More talks by Peter: 1) origin of the laws of nature (https://youtu.be/p9Zmzcl85Ds) 2) where do the laws of nature come from (https://youtu.be/0_ckzZWDth8) 3) why emergence is significant (https://youtu.be/rAeEozekhu4) Music by: Ahmed Hassan ( ) #reasonwithscience #physics #multiverse

This episode is with Charles Brenner. He is the Alfred E Mann Family  Foundation Chair in the department of Diabetes and Cancer Metabolism.  His research focuses on disturbances in nicotinamide adenine  dinucleotide (NAD), the central catalyst of metabolism, in diseases and  conditions of metabolic stress.   Here we talk about what is metabolism?, NAD system, factors affecting  NAD system, ageing, anti-ageing research and how NAD system can be used  in health?   Guest info:  Website: https://www.brennerlab.net/  Twitter: https://twitter.com/CharlesMBrenner?s=20&t=sP8HvddsdScE8qzeQN_t3Q  Google scholar: https://scholar.google.com/citations?user=XgEjtucAAAAJ&hl=en   Episode links:   Website: https://www.reasonwithscience.com/home/understanding-metabolism-and-aging-with-charles-brenner  Youtube: https://youtu.be/DHh_E3BbtmI  Spotify: https://open.spotify.com/episode/4q1tqsDiIuwi3jNtdZP2UM?si=QB1KgNMxQpu5dJvlNGLqWQ  Apple podcast:  https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/understanding-metabolism-and-aging-|-charles-brenner-|-reason-with-science-|-nad-system-|-anti-aging/8ca959ec-8bbe-466b-a4e5-d2399d40a452  Google podcast:  https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/YmUxZmQyZDEtMjI1ZC00N2FlLWJjMjAtNjVmZDZkZDRiYzc1?sa=X&ved=0CAUQkfYCahcKEwiou6WW76v7AhUAAAAAHQAAAAAQLA   Follow Reason with Science:   Website: https://www.reasonwithscience.com/   Youtube: https://www.youtube.com/channel/reasonwithscience   Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh   Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894   Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw    Timestamps:  00:00:00 Introduction  00:00:51 What is metabolism?  00:01:40 Metabolism at cellular level  00:02:44 Different metabolic processes   00:04:50 NAD (Nicotinamide adenine diamide) system   00:08:20 Food to NAD system    00:13:09 Evolutionary history of NAD system    00:15:44 Molecular description of NAD system   00:20:51 Synthesis of NAD   00:23:21 What is metabolic stress?   00:28:23 Consequences of metabolic stress on NAD system   00:29:45 Conditions caused by NAD deficiency   00:34:23 Impact of food on metabolic stress   00:35:51 Different types of foods and NAD levels   00:40:01 NAD levels and circadian rythem   00:40:50 Genetic predisposition to NAD levels  00:42:40 Are there population wide changes in NAD systems?   00:47:25 Importance of NAD levels in the blood and how much of these can enter in the cell?   00:50:08 Are there modified NMN compounds which can enter in the cell?   00:52:01 NAD system and aging   01:02:25 Objection against 'Sirtuins as drivers of aging'  01:04:29 How do we understand aging?  01:08:25 Biochemical explanation of aging   01:12:20 What kind of biomarkers can help is in studying aging?   01:15:33 Charles' work on NAD system   01:17:05 What sort of system can help us study aging?   01:23:37 Lifestyle and NAD system    01:26:07 NR (Nicotinamide Ribose) as supplements   01:27:19 Thank you!     #reasonwithscience #health #aging

This episode is with William Ratcliff. He is an Associate Professor at the School of Biological Science at Georgia Tech. Will studies the physics that constrains multicellular structures and examines the minute changes in certain yeast cells that allows them to become multicellular. Here we talk about origin of life, emergence of complexity, eukaryogenesis, how cells become multicellular? and major questions regarding how multicellularity evolves. Guest info: Website: https://ratclifflab.biosci.gatech.edu/ Twitter: https://twitter.com/wc_ratcliff?s=20&t=V9HDIs-TNdMJazo02F8v5Q Google scholar: https://scholar.google.com/citations?user=wdVRIS0AAAAJ&hl=en Episode links:  Website: https://www.reasonwithscience.com/home/how-multicellularity-evolves-with-william-ratcliff Youtube: https://youtu.be/HOrNrg2H5Ok Spotify: https://open.spotify.com/episode/0xWzhzWozsnIppGpcN1fNx?si=iMvD48OVSPqxhZTfnxv4CQ Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/how-multicellularity-evolves-with-william-ratcliff/20ca73cb-7550-451a-9dae-84e1c415ebed Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/MmIyMGYzZTYtMWY3My00M2UxLTk1YzgtNTQ0MDZlZGJmNmQ5?sa=X&ved=0CAUQkfYCahcKEwio98jQh4n7AhUAAAAAHQAAAAAQLA Follow Reason with Science:  Website: https://www.reasonwithscience.com/  Youtube: https://www.youtube.com/channel/reasonwithscience  Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh  Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894  Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw  Timestamps: 00:00:00 Introduction 00:00:50 Origin of life 00:09:02 Protocells and Last Universal Common Ancestor (LUCA) 00:11:58 Origin of LUCA 00:14:47 Evolution of life from LUCA 00:20:35 Prokaryotes and Eukaryotes 00:27:44 Semantics of colonies, communities and multicellularity 00:38:25 Kin selection and Group selection debate 00:43:12 Reductionism in science   00:49:32 Strong emergence 00:55:49 Snowflake yeasts 01:11:20 Multicellularity in bacteria 01:14:10 Reproduction in yeasts 01:21:11 Growth regulation in snowflake yeasts 01:27:47 Reproduction of snowflake yeasts 01:34:44 Evolutionary game theory 01:38:34 Michael Levin's work on Xenobots  01:41:56 Darwinian evolution is crucial for multicellular systems to evolve 01:47:01 How cellular functions are regulated in multicellular systems? 01:54:52 Nicole King's work on Choanoflagellates  01:57:19 Polarity in multicellular systems 01:59:32 Syncytia (Multinuclear) cells 02:04:22 Snowflake system and major questions about multicellularity  02:15:09 Reverting multicellularity 02:18:09 Thank you!

This episode is with Chris Ferrie. He is an associate Professor at the  University of Technology Sydney and Centre for Quantum Software and  Information. His research focuses on quantum information science. Chris  also writes children's books and some selected titles include Quantum  Physics for Babies, 8 Little Planets and Pandemics for Babies. In  this conversation we talk about beginning of quantum physics, Double  slit experiment, matter, understanding reality, quantum entanglement and  quantum computing.   Guest info: Website: https://www.csferrie.com/ Twitter: https://twitter.com/csferrie Amazon: https://www.amazon.com/Chris-Ferrie/e/B00IZILZR6/ref=aufs_dp_fta_dsk Youtube: https://www.youtube.com/csferrie   Episode links:   Website: https://www.reasonwithscience.com/home/quantum-physics-for-babies-with-chris-ferrie  Youtube: https://youtu.be/fn1W6Ml_8yY Spotify: https://open.spotify.com/episode/0R2jkglSrfguE347uF4oxk  Apple podcast:  https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/quantum-physics-for-babies-with-chris-ferrie/100f0595-9def-45e2-bc95-910415a5a077  Google podcast:  https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/NDRhZWI0YWEtYWY3OC00ZTAzLThhY2QtYTQyNzhlZDM1Yzk4?sa=X&ved=0CAUQkfYCahcKEwiItfPahvP6AhUAAAAAHQAAAAAQLA    Follow Reason with Science: Website: https://www.reasonwithscience.com/ Youtube: https://www.youtube.com/channel/reasonwithscience Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894 Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw    Timestamps:  00:00:00 Introduction  00:00:55 Do we understand quantum physics?   00:03:50 Double slit experiment     00:08:43 Max Planck and Einstein's work   00:09:58 Early development of quantum theory  00:12:05 'Quantum' in quantum physics   00:12:41 Heisenberg's principle  00:18:56 Schrodinger's equation   00:20:10 Quantum superposition and quantum entanglement   00:22:53 How to understand quantum entanglement?   00:27:26 Measurement   00:30:13 What is matter and nature of reality? 00:34:22 Reductionism  00:36:07 Emergence and theory of everything  00:39:49 Science of chaos/luck/chance  00:42:11 Understanding chaos  00:43:54 Quantum information  00:50:07 Quantum information and consciousness  00:51:31 Work of Bernardo Kastrup and Donald Hoffman  00:54:54 (Eugene) Wigner's friend    00:59:44 Decoherence in quantum physics   01:02:31 Quantum computers  01:07:09 How big are quantum computers?  01:10:10 Problem with quantum computers  01:11:20 2022 Nobel prize in physics   01:15:04 Quantum systems in action   01:18:06 Writing science books for babies  01:21:08 Thank you!

This episode is with Lars Chittka. He is a professor at Queen Mary,  University of London. Lars is an expert on the behaviour, cognition and  ecology of Bees, and their interactions with flowers. His latest book is  'The mind of a Bee' where he explores the vast amount of work done on  the Bee behavior. In this conversation we talk about structure of Bee colonies, Nature-nurture, cognition, intelligence and consciousness.   Guest info: Website: http://chittkalab.sbcs.qmul.ac.uk/ Twitter: https://twitter.com/LChittka Amazon:  https://www.amazon.com/Mind-Bee-Lars-Chittka/dp/0691180474 Music band: Lars is also a part of a band 'Killer Bee Queens', check out  their music here  (https://killerbeequeens.bandcamp.com/album/strange-flowers)   Episode links: Website: https://www.reasonwithscience.com/home/the-mind-of-a-bee-with-lars-chittka Youtube: https://youtu.be/-DWpFy0ToX4 Spotify: https://open.spotify.com/episode/0OoqlmcEK3IJLpSBHYG1EE?si=EIzoP0OZQO6XkzZZbXeIdw Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/the-mind-of-a-bee-with-lars-chittka/a4e353ce-37d8-4046-8cbf-310767565ebe Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/MjlkYzQxZWQtY2FhZi00NmZjLWJhM2ItNjUyODhlNzM3YmQ5?sa=X&ved=0CAUQkfYCahcKEwigjbq75eH6AhUAAAAAHQAAAAAQLA   Follow Reason with Science: Website: https://www.reasonwithscience.com/ Youtube: https://www.youtube.com/channel/reasonwithscience Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894 Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw    Timestamps: 00:00:00 Introduction 00:00:51 Most alien thing about Bees 00:02:12 Words of Maurice Maeterlinck 00:03:32 How do Bees perceive the world? 00:05:11 Seeing UV light 00:05:43 How a new born Bee would learn about its world? 00:08:25 Evolution of sensitivity to UV 00:11:00 Bee and flower evolution 00:13:41 How a Bee manages task of foraging? 00:18:31 Can Bees see in the Dark? 00:23:15 Cognitive maps in Bees 00:26:44 Landmarks recognition by Bees 00:28:06 Are Bees social animals? 00:36:28 Bees as carnivores 00:38:46 Social structure of Bees 00:45:01 Understanding nature-nurture from social insects 00:50:33 When the fate (to be a worker or not) of a Bee is decided? 00:52:18 Arms race between queen and works 00:54:02 Making of a Queen 00:58:21 Bee nest 01:01:17 Plasticity in Bee communication 01:07:21 Intelligence and cognition in Bees 01:14:29 Memory and Metacognition   01:23:50 Are Bees conscious?   01:37:52 Hard problem of consciousness 01:43:38 Importance of Bees   01:47:08 Bee conservation   01:54:29 Sensory, perception system of Bees and AI   01:58:58 Thank you!  #reasonwithscience #consciousness  #intelligence

This episode is with Geraint Lewis.  He is a Professor of Professor of Astrophysics at the Sydney Institute  for Astronomy, part of the University of Sydney's School of Physics. His  research focuses on the 'dark side of the universe', the matter and  energy that shapes our cosmos. His books include 'A fortunate universe'  and 'The cosmic revolutionary's handbook'. His latest book is 'Where did  the universe come from' co-authored by Prof. Chris Ferrie.  In this conversation we talk about theory of gravity, quantum physics,  Big Bang, Expansion of the universe?, Matter, how do the elements form?,  Antimatter, Dark matter and Dark energy.    Guest info:  Website: https://www.geraintflewis.com/  Twitter: https://twitter.com/Cosmic_Horizons  Amazon: https://www.amazon.com/Geraint-F-Lewis/e/B01FRL8Y6I?ref=sr_ntt_srch_lnk_2&qid=1665204017&sr=8-2   Episode links:   Website: https://www.reasonwithscience.com/home/where-did-the-universe-come-from-with-geraint-lewis Youtube: https://youtu.be/ep5fVxS82FA Spotify: https://open.spotify.com/episode/5i1wq8JfVXvphLWxwEPwrL?si=0010caeae15e429b Apple podcast:  https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/where-did-the-universe-come-from-with-geraint-lewis/0255437b-a7bd-42cb-a770-2e85bc89a92d Google podcast:  https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/YmM5NTgyMDItMGFjNi00OTZhLWE0MjEtNzE0ZThlOTcyOThl?sa=X&ved=0CAUQkfYCahcKEwiw_ve6itD6AhUAAAAAHQAAAAAQLA Follow Reason with Science:   Website: https://www.reasonwithscience.com/   Youtube: https://www.youtube.com/channel/reasonwithscience   Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh   Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894   Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw    Timestamps:  00:00:00 Introduction  00:01:16 Do we have to presuppose the existence of the universe?  00:05:49 Something from nothing    00:07:14 'What is nothing?'    00:08:26 Theory of gravity and Quantum physics   00:14:30 Standard model in physics   00:16:17 Understanding matter   00:19:00 Why we can't include gravity at quantum level?   00:20:58 Scale matters for gravity   00:21:52 Scales for Quantum effects   00:26:46 Evidence for Big Bang   00:32:53 What is fundamental?   00:37:47 Space-time is doomed   00:43:09 Universe emerging from another universe   00:45:54 How to envision Big Bang?   00:49:16 Forces at work at the Big Bang   00:58:46 Idea of the multiverse   00:59:41 Fine tuning to produce elements in the universe   01:04:10 Are all electrons same?  01:11:00 Formation of the elements   01:14:12 How do various elements reach on the planets?     01:21:20 Antimatter and why matter exist?   01:31:29 Dark matter and Dark energy   01:34:16 Question of emergence   01:35:46 How does angular momentum get included in Dark matter models of galactic rotation?   01:39:24 Can we create a universe?   01:41:02 Thank you!  

This episode is with Nick Enfield. He is a Professor of Linguistics at the University of Sydney. Nick's research on language, culture, cognition and social life is based on long term field work in mainland Southeast Asia, especially Laos. His books include Natural Causes of Language, Distributed Agency, and How We Talk. His latest book is 'Language vs Reality: Why language is good for lawyers and bad for scientists' In this conversation we talk about evolution of language and How well it can describe reality?, Can language nudge our thoughts?, Maths as a language, evolution of human reason and rationality.  Guest info: Website: http://nickenfield.org/ Google scholar: https://scholar.google.com/citations?user=ZZ6woWgAAAAJ&hl=en&oi=sra Twitter: https://twitter.com/njenfield?s=20&t=rt6kyVo-IRUsdRu1Q4_W7g Episode links:   Website:  https://www.reasonwithscience.com/home/can-language-describe-reality-with-nick-enfield  Youtube: https://youtu.be/lWzE55QeVDc  Spotify:  https://open.spotify.com/episode/2Hc9rPQQKHeboy2TINF0ik?si=ifgkA1KxSoCGM4qS0U4iqQ  Apple podcast:  https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/can-language-describe-reality-with-nick-enfield/dc89efc0-0bf4-4e35-85c2-f740fae73591  Google podcast:   https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/M2YyNTFjOTktNzZjMy00Y2Q3LWFhOTAtYzNhOGIzZmI0NDg2?sa=X&ved=0CAUQkfYCahcKEwj4w-iF0L76AhUAAAAAHQAAAAAQAQ Follow Reason with Science:   Website: https://www.reasonwithscience.com/   Youtube: https://www.youtube.com/channel/reasonwithscience   Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh   Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894   Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw Timestamps:  00:00:00 Introduction  00:01:07 What is language?   00:04:01 When does a communication system becomes a language?  00:08:02 How language got started?   00:13:31 Do sapiens have an advantage which helped us to start a language?  00:17:30 Language is too blunt for scientists and good for lawyers   00:23:40 We simplify the complexity of the world  00:28:23 Why language was evolved?  00:30:52 On Donald Hoffman's work  00:35:36 Brute reality and social reality  00:36:59 Yuval Harrari's imagined reality   00:40:38 Power of all the languages  00:44:29 Language in an AI society  00:47:25 Complexity of a language  00:56:18 Can complexity of a language affect psychology?    01:00:08 Sapira-Whorf hypothesis  01:04:07 Co-evolution and evolution of languages   01:08:05 Desmond Morris' work on neoteny  01:10:54 Purpose of a language  01:16:04 Rationality, reasoning and language   01:22:35 Truth and rationality  01:27:45 Fighting misinformation 01:30:19 Confirmation bias  01:31:55 Should we care if a language is dying?  01:38:06 Is mathematics a language?  01:44:26 Thank you!   #reasonwithscience #languages #evolution

This is second part of the conversation with Randy Schekman. He is an  investigator of the Howard Hughes Medical Institute and a Professor of  Cell and Developmental Biology in the Department of Molecular and Cell  Biology at the University of California at Berkeley. He was awarded the Nobel Prize in Physiology or Medicine in 2013 for his  role in revealing the machinery that regulates the transport and  secretion of proteins in our cells. He shares the prize with James E.  Rothman of Yale University and Thomas C. Südhof of Stanford University.  In this conversation we talk about his work on scientific publishing,  his suggestions for  early-career researchers and his experience on Parkinson's project.   Listen to part I here: https://youtu.be/bl1uG4PbTOE  Find more about Randy's work: http://mcb.berkeley.edu/labs/schekman/  Randy's biography: https://www.nobelprize.org/prizes/medicine/2013/schekman/facts/  Episode links:  Website: https://www.reasonwithscience.com/home/the-noble-journey-with-randy-schekman-ii  Youtube: https://youtu.be/MNjfkoutAhQ  Spotify:   Apple podcast:    Google podcast:     Follow Reason with Science:    Website: https://www.reasonwithscience.com/    Youtube: https://www.youtube.com/channel/reasonwithscience    Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh    Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894    Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw Timestamps:  00:00:00 Introduction  00:00:49 How to select a scientific question?  00:05:13 Bold ideas survive in science!    00:06:50 Importance of collaboration in science  00:12:24 ASAP project model for early career researchers   00:13:03 Change in the evaluation process  00:19:25 How to understand quality of science?  00:24:31 Parkinson's project (ASAP)   00:28:02 Why scientific publishing can change?   00:29:43 Understanding of scientific method to improve scientific publishing!  00:31:37 Any shift in pressure of publishing?   00:32:58 More about Parkinson's project (ASAP)  00:38:38 Role of unstructured proteins in neurodegenerative diseases   00:41:41 Unstructured proteins are the next problem!  00:42:38 No markers for Parkinson's so far!  00:43:50 Causes of Parkinson's  00:45:06 What can be a potential cure of Parkinson's?   00:47:12 Thank you!   More Talks from Randy:  TEDx on scientific publishing: https://youtu.be/-N4Mb8tsyT8  iBiology: https://youtu.be/xvjUgTKlKyU  Nobel prize inspiration initiative lecture: https://youtu.be/Udg6bYkBtX8   #reasonwithscience #nobelprize #science

This is first part of the conversation with Randy Schekman. He is an  investigator of the Howard Hughes Medical Institute and a Professor of  Cell and Developmental Biology in the Department of Molecular and Cell  Biology at the University of California at Berkeley. He was awarded the Nobel Prize in Physiology or Medicine in 2013 for his  role in revealing the machinery that regulates the transport and  secretion of proteins in our cells. He shares the prize with James E.  Rothman of Yale University and Thomas C. Südhof of Stanford University.  In this conversation we talk about his early career, membranes,  exosomes, scientific publishing and Elife journal.  Listen to part II: https://youtu.be/MNjfkoutAhQ  Find more about Randy's work: http://mcb.berkeley.edu/labs/schekman/  Randy's biography: https://www.nobelprize.org/prizes/medicine/2013/schekman/facts/  Episode links: Website: https://www.reasonwithscience.com/home/the-noble-journey-with-randy-schekman-i Youtube: https://youtu.be/bl1uG4PbTOE  Spotify:  Apple podcast:   Google podcast:   Follow Reason with Science:   Website: https://www.reasonwithscience.com/   Youtube: https://www.youtube.com/channel/reasonwithscience   Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh   Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894   Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw Timestamps:  00:00:00 Introduction  00:01:08 Interest in microbes  00:05:27 Yeasts have feelings too!  00:06:24 What was already known about vesicular trafficking?  00:08:42 How do you envision a cell?   00:09:51 Your work to understand 'what is life'?  00:12:48 Formation of membranes for the origin of life  00:14:39 Why membranes are ideal for life!  00:15:48 Differences of membranes   00:17:07 The evolution of membranes  00:19:02 Starting the work on vesicular trafficking  00:23:09 Discovery of COPII complex  00:25:24 The specialty of COPII complex   00:26:30 Importance of vesicular trafficking for animal physiology  00:27:39 Understanding of gut feeling!  00:28:56 What has changed after Nobel prize?  00:30:30 Different cellular trafficking system  00:32:11 Exosomes and miR223   00:34:29 Problems with exosomes as therapeutics  00:35:08 Peer-review and scientific publishing  00:39:44 Genesis of Elife   00:44:05 Impact factor of Elife  00:46:35 Thank you!   More Talks from Randy:  TEDx on scientific publishing: https://youtu.be/-N4Mb8tsyT8  iBiology: https://youtu.be/xvjUgTKlKyU  Nobel prize inspiration initiative lecture: https://youtu.be/Udg6bYkBtX8   #reasonwithscience #nobelprize #cellbiology

This episode is with Nick Lane. Nick is a professor of Evolutionary Biochemistry at University College London. He is an author of several books like Power, Sex, Suicide; Life ascending and the Vital question. His latest book is Transformer: The Deep Chemistry of Life and Death. Here we talk about What is life?, Life as an information, importance of Krebs cycle, How did the life start?, consciousness, chronic diseases like cancer and process of ageing. Guest info: Website: https://nick-lane.net/ Amazon: https://www.amazon.com/Nick-Lane/e/B001IXSEJ2/ref=dp_byline_cont_pop_book_1 Google scholar: https://scholar.google.co.uk/citations?hl=en&view_op=list_works&gmla=AJsN-F4olJCJHK40l0_0fVpJFgPP2JYynLUs5cpCsX0ADVj9y4VIo99TJ598Hr0_ItDJucJJGG4Tlxw9nr0zvdBMl8ow3iI3rA&user=eChselQAAAAJ Episode links: Website: https://www.reasonwithscience.com/home/chemistry-of-life-and-death-with-nick-lane Youtube: https://www.youtube.com/watch?v=YolIkk_oJdI Spotify: https://open.spotify.com/episode/0rgEE8ZHA8wOMFcDm9k00X?si=Efq33fLXRs66vb5d6KlPVw Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/chemistry-of-life-and-death-with-nick-lane/48ce9fbe-5e92-43cd-a97a-4d6b846a7888 Google podcast: https://podcastsmanager.google.com/episode?show=show%3AktGOqSvOM5S386E5jDIB0g&episode=aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3BsYXkvNTgwNDQxMTUvaHR0cHMlM0ElMkYlMkZkM2N0eGxxMWt0dzJubC5jbG91ZGZyb250Lm5ldCUyRnN0YWdpbmclMkYyMDIyLTgtMjQlMkZlODhmZjcyMC01MWJkLTE2ZWYtYzg5Mi0xMTg3MGM2N2EwZGMubXAz&daterange=LAST_28D&hl=en Follow Reason with Science: Website: https://www.reasonwithscience.com/ Youtube: https://www.youtube.com/channel/reasonwithscience Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894 Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw Timestamps: 00:00:00 Introduction 00:01:50 Is 'What is life?' a right question? 00:05:10 Information view of life 00:08:02 Importance of metabolism for origin of life 00:14:27 Gases giving rise to life stuff 00:24:06 Why life doesn't form in a cola bottle? 00:25:20 Oxygen based life 00:31:06 Eukaryogenesis 00:41:07 Respiration in bacteria and mitochondria 00:44:29 Electrical potential on membranes 00:52:24 Membrane inheritance 00:58:04 Krebs cycle and reverse Krebs cycle 01:06:54 Recycling of mitochondria for health 01:15:24 Answering important questions in science 01:18:19 Biology of fields 01:32:11 Reductionism in science 01:35:33 How anesthetics affect bacterial or mitochondrial membranes? 01:45:43 Quantum biology 01:59:05 Lee Cronin's idea of synthetic life 02:01:35 Lee Cronin and Sara Walker's assembly theory 02:05:39 Can we simplify present biochemistry? 02:17:53 Thank you! #reasonwithscience #biology #biochemistry