
Reason with Science
Welcome to "Reason with Science", the podcast that explores the intersection of reason and science in our everyday lives. Billions of years of evolution led to a species which is asking questions about its own existence. This quest of humans is not possible without science. As we navigate an increasingly complex world, it's more important than ever to approach issues with a clear and evidence-based understanding. In this podcast, we'll dive into the latest research, explore fascinating topics, and interview experts in their respective fields to help us make sense of the world around us.
Latest episodes

Mar 11, 2023 • 58min
Art of Science communication | Lee McIntyre | Reason with science | Flat earthers | Antivaxx
This conversation is with Lee McIntyre. He is a Research Fellow at the Center for Philosophy and History of Science at Boston University and an Instructor in Ethics at Harvard Extension School. In this conversation we talk about what is science, importance of scientific method, science deniers, flat earthers, Anti-Vaxx, GMO deniers and climate change deniers.
Guest info:
Website: https://leemcintyrebooks.com/about-lee/
Twitter: https://twitter.com/LeeCMcIntyre
Amazon: https://www.amazon.com/stores/Lee-McIntyre/author/B001IXPVPM?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true
Episode links:
Website: https://www.reasonwithscience.com/home/art-of-science-communication-with-lee-mcintyre
Youtube: https://youtu.be/XgZM0vaNBu4
Spotify:
Apple podcast:
Google podcast:
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
0:00 Introduction
01:10 Philosophy of science and science denial
03:19 Flat earther convention
06:00 What do science deniers lack?
07:54 What is scientific method?
10:51 Distinction between skeptics and science deniers?
16:00 Need to feel different for science deniers?
17:23 Attitude of scientific community?
20:35 'No one cares about climate change outside Maldives'
24:35 Vaccination denial
29:25 GMO deniers
34:02 Is there a correlation between science denial ideologies?
36:48 Can scientists be corrupt?
39:40 How science reaches to consensus?
41:47 How to maintain trust in changing science?
44:34 Backfire effect?
49:12 What science can give them as an identity?
51:36 Impact of using terms 'Science deniers'.
52:18 Correlation between countries with science deniers and how they handled pandemic?
53:34 Does it really matter to convert science deniers?
54:45 What more to read?
56:23 Find more information about Lee's work.
56:52 Thank you!

13 snips
Mar 5, 2023 • 1h 55min
Physical reality and mind with Chris Fields | Reason with Science | Quantum theory | Consciousness
This episode is with Chris Fields. He is an independent scientist with a PhD in Philosophy from the University of Colorado. Here we talk about what is a self?, nature of consciousness, physical reality, quantum field theory, panpsychism, boundaries of cognition, complex systems and a theory of consciousness.
Guest info:
Website: https://chrisfieldsresearch.com/
Episode links:
Website: https://www.reasonwithscience.com/home/physical-reality-and-mind-with-chris-fields
Youtube: https://youtu.be/Mu_kW11ap8M
Spotify: https://open.spotify.com/episode/0ULSen1QoFeFLE2bOVi29P
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/physical-reality-and-mind-with-chris-fields-%7C-reason-with-science-%7C-quantum-theory-%7C-consciousness/d4828162-f8b0-4b97-8203-d7cb01c2e059
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/MzBjMDI4ODUtNWUwZS00MzJhLTllZDEtMWRhNzgzODMyZDQ2?ep=14
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:00:53 What is a self?
00:06:13 Difference between a self of a bacteria and human?
00:11:20 Self and a mind
00:14:22 Consciousness and a self
00:20:13 Panpsychism
00:22:25 Boundaries of cognition
00:26:40 Properties of LUCA (Last Universal Common Ancestor)
00:34:22 Memory and information in a system
00:39:24 How far we can stretch the understanding of boundaries?
00:45:14 Where is a self in the transitions of matter?
00:51:31 Language trap in exploring consciousness
00:56:20 Scale of consciousness
01:05:20 Attributing consciousness to chemistry
01:07:20 Consciousness during the development of a human
01:11:11 What would it mean to have a theory of consciousness?
01:16:17 Experience of larger and complex systems
01:20:03 Understanding complexity
01:27:48 Building complex systems like AI
01:32:32 What makes internet so complex?
01:35:34 Mike Levin's work to create Xenobots
01:41:00 Creating artificial bacteria
01:45:26 Origin of life
01:54:08 Thank you!
Music by: Ahmed Hassan (https://www.youtube.com/@2ays577/featured)

Feb 26, 2023 • 1h 11min
The evolutionary origins of a good society | Nicholas Christakis | Reason with Science | Psychology
This episode is with Nicholas Christakis. He is the Sterling Professor of Social and Natural Science at Yale University, where he directs the Human Nature Lab. He is also the Co-Director of the Yale Institute for Network Science. His research focuses on social networks and the socioeconomic, biosocial, and evolutionary determinants of behavior, health, and longevity.
Here we talk about nature nurture, The social suite which includes seven core properties of any good society, The forbidden experiment in sociology, and morality.
Guest info:
Website: https://humannaturelab.net/people/nicholas-christakis
Twitter: https://twitter.com/NAChristakis
Amazon: https://www.amazon.com/s?i=stripbooks&rh=p_27%3ANicholas+A.+Christakis+MD++PhD&s=relevancerank&text=Nicholas+A.+Christakis+MD++PhD&ref=dp_byline_sr_book_1
Episode links:
Website: https://www.reasonwithscience.com/home/the-evolutionary-origins-of-a-good-society-with-nicholas-christakis
Youtube: https://www.youtube.com/watch?v=61-cE2z-aWI
Spotify: https://open.spotify.com/episode/2WjOykglFgmydegQ18QajI
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/the-evolutionary-origins-of-a-good-society-|-nicholas-christakis-|-reason-with-science-|-psychology/904d4179-7dc4-4a6f-b8c2-a5c13e520d7c
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/NDQ0NmFiMDUtMDI5ZS00NzAxLWFhNjYtMjQ3MjgxNTQ0YzBi?sa=X&ved=0CAUQkfYCahcKEwjor4S5ybP9AhUAAAAAHQAAAAAQQw
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:01:03 Major questions about human societies
00:07:16 Importance of human social networks
00:09:58 Nature- nurture debate
00:14:15 The social suite
00:16:06 Importance of the social society in creating a human society
00:22:17 Going beyond the social suite in a society
00:24:25 Extended phenotype and Exo-phenotype
00:29:36 Exo-phenotype and Darwinian evolution
00:30:30 Importance of an individual in a society
00:34:48 In-group bias
00:44:56 How much we can change 'In-group bias'?
00:47:03 Robert Sapolsky's 'Categorical thinking'
00:53:05 Life on Mars
00:54:11 Importance of Mild hierarchies
00:55:49 Mentorship over Narcissism
01:01:39 Love in human societies
01:06:15 Morality
01:09:11 Thank you!

Feb 19, 2023 • 1h 2min
Physics of Black Holes with Chris Impey
This episode is with Chris Impey. He is a university Distinguished Professor of Astronomy at the University of Arizona. For 17 years he was Deputy Head of the Astronomy Department at the University of Arizona, and he is currently Associate Dean of the College of Science. His research focuses on observational cosmology—using telescopes and other instruments to study the large-scale structure and evolution of the universe. Here we talk about Einstein's monsters, How do black holes form?, Types of black holes?, Information paradox, Supernova, Dark matter and Dark energy.
Guest info:
Website: http://chrisimpey-astronomy.com/
Twitter: https://twitter.com/ImpeyChris
Amazon: https://www.amazon.com/stores/Chris-Impey/author/B001IZXGTS?isDramIntegrated=true&ref=ap_rdr&shoppingPortalEnabled=true&store_ref=ap_rdr
Episode links:
Website: https://www.reasonwithscience.com/home/physics-of-black-holes-with-chris-impey
Youtube: https://youtu.be/n_0Wp0s39Es
Spotify: https://open.spotify.com/episode/7juYOARFZeR2Z1lr7oA0Bw
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/physics-of-black-holes-with-chris-impey/a1ca48fd-09ea-438f-98c9-54bdfc907c8b
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/ZmI1MzU1NGItM2EyOC00NjAwLWFhYzItMGQ5YTgzN2RjYjE5?sa=X&ved=0CAUQkfYCahcKEwjYy_zTm6H9AhUAAAAAHQAAAAAQAQ
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw

Jan 28, 2023 • 1h 51min
Big Bang, Black holes and Gravitational waves | Abhay Ashtekar | Reason with Science | Physics
This episode is with Abhay Ashtekar. He is Evan Pugh Professor of Physics at Penn State, where he also holds the Eberly Chair. In 1993, he founded the Institute of Gravitation and the Cosmos. Ashtekar’s scientific work focuses on theoretical aspects of general relativity, cosmology and quantum gravity. Here we talk about what is gravity?, loop quantum gravity, The big bang, The big bounce, Singularities, Black holes and gravitational waves.
Guest info:
Website: https://science.psu.edu/physics/people/abhay-ashtekar
Biography: https://www.aip.org/history-programs/niels-bohr-library/oral-histories/45807
Episode links:
Website: https://www.reasonwithscience.com/home/big-bang-black-holes-and-gravitational-waves-with-abhay-ashtekar
Youtube: https://youtu.be/_eYw_MQXIhM
Spotify: https://open.spotify.com/episode/1W2ltjs6l9I0WSAo9CYEKh
Apple podcast: https://podcasts.apple.com/cz/podcast/big-bang-black-holes-and-gravitational-waves-abhay/id1641776894?i=1000597045107
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/NDc4OGIxMGMtNDY4My00ZmRiLWE0OWUtZjMyYjhkYmIyYTA1?ep=14
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:00:52 What is gravity?
00:10:50 Einstein's equivalence principle
00:15:34 Importance of geometry in physics
00:19:04 Introduction to quantum field theory
00:23:50 Einstein's work on quantum mechanics
00:25:04 Quantum field theory to explain reality
00:33:10 Scale of theory of relativity and quantum field theory
00:37:50 Introduction to loop quantum gravity
00:52:44 Gravity is a weak force
00:54:45 'Loops' in loop quantum gravity
01:05:20 Difference between strings and quantum threads
01:07:04 Status of Gravitons
01:10:58 Importance of gravitons
01:15:12 Gravitational waves
01:17:34 What is a black hole?
01:21:16 Black holes and loop quantum gravity
01:27:12 The Big Bounce
01:38:00 Loop quantum cosmology
01:39:07 Big bounce and the universe
01:41:31 Validating loop quantum gravity
01:45:25 Recommended reading
01:49:51 Thank you!
Recommended reading:
The Story of Loop Quantum Gravity- From the Big Bounce to Black Holes https://www.youtube.com/watch?time_continue=1042&v=x9jYH5VIF9E Before the Big Bang 1 - Loop Quantum Cosmology Explained https://www.youtube.com/watch?v=IFcQuEw0oY8&feature=c4-overview&list=UUtOgKmAM4MeFu-jd-HB3_cg A
Short Review of Loop Quantum Gravity, by A. Ashtekar and E. Bianchi, https://arxiv.org/pdf/2104.04394.pdf
Quantum Space-time: Beyond the continuum of Minkowski and Einstein, by A. Ashtekar, https://arxiv.org/pdf/0810.0514.pdf
Clip: New Meaning of the Big Bang.
https://www.youtube.com/watch?v=U7kvjTRW-tw&feature=youtu.be

Jan 21, 2023 • 1h 6min
Viruses: The enigma of life with Pavel Plevka
This episode is with Pavel Plevka. He is a research group leader at Central European institute of technology (CEITEC). His research is focused on solving the structures of viruses in order to understand their mechanism of action.
For this conversation, My co-host is Anna Papageorgiou (https://twitter.com/AnnaCalypte).
Here we talk about general aspects of viruses, their genomes, evolution of viruses, their infection strategies, impact of viruses on human health, environment and agriculture.
Guest info:
Website: https://www.ceitec.cz/doc-mgr-pavel-plevka-ph-d/u26854?page=publication
Twitter: https://twitter.com/PlevkaLab
Episode links:
Website: https://www.reasonwithscience.com/home/viruses_the_enigma_of_life_with_pavel_plevka
Youtube: https://youtu.be/c2TRLkbDVa8
Spotify: https://open.spotify.com/episode/3J2A6psAbgwudGcaBXoePS?si=NNPZNbTbR52KZVSVKW_eyw
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/viruses-the-enigma-of-life-with-pavel-plevka/e369efdf-1cd7-42ff-967c-2937d6be3edd
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/YWJiMDRiY2EtYThjMC00M2M4LWExNWQtNWI3MjNkNDI3YmYw?sa=X&ved=0CAUQkfYCahcKEwj4qOK4q9v8AhUAAAAAHQAAAAAQLA
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:01:01 What is a virus and why do we study them?
00:02:02 Size of a viruses
00:03:57 Viroids and Gene Transfer Agents (GTA)
00:05:17 How to visualize viruses?
00:07:03 Different structures of viruses
00:08:34 Classification of viruses
00:10:01 How do viruses recognize their hosts and infect them?
00:16:58 Viral mechanism of action
00:19:42 How viruses can infect multiple hosts?
00:21:52 Essential features of viral genomes
00:23:30 Membranes and envelopes of viruses
00:26:05 Evolutionary origins of viruses
00:29:22 Why viruses are not part of the tree of life?
00:30:17 Co-evolution of viruses and hosts
00:37:24 How widespread viruses are?
00:39:47 Therapeutic strategies against viruses
00:42:26 Prevention against viruses
00:44:55 Phage therapy
00:47:27 Use of viruses in cancer therapies
00:49:00 Gene therapy
00:51:02 Importance of viruses for ecology
00:54:44 How viruses survive the extreme conditions?
00:58:40 Honeybee viruses
01:00:12 Do viruses carry known functions?
01:01:35 Are viruses alive?
01:02:29 What the technology lacks?
01:03:34 Pavel's favorite virus
01:04:21 Recommended article
01:05:10 Thank you!
Music by: Ahmed Hassan (https://www.youtube.com/@2ays577/featured)

Dec 25, 2022 • 1h 37min
Emergence of the universe | Peter Atkins | Reason with Science | Multiverse | Physics
This episode is with Peter Atkins. He is a chemist and a Fellow of Lincoln College at the University of Oxford. Peter is a prolific writer of popular chemistry textbooks, including Physical Chemistry, Inorganic Chemistry, and Molecular Quantum Mechanics.
Here we talk about what are the laws of nature?, fundamental constants, emergence in the universe, strong and weak emergence, multiverse and a theory of everything.
Guest info:
Amazon: https://www.amazon.com/Books-Peter-Atkins/s?rh=n%3A283155%2Cp_27%3APeter+Atkins
Wikipedia: https://en.wikipedia.org/wiki/Peter_Atkins
Episode links:
Website: https://www.reasonwithscience.com/home/emergence-of-the-universe-with-peter-atkins
Youtube: https://youtu.be/o14rvWAXiJk
Spotify: https://open.spotify.com/episode/2YQUiJSqLSjXm6grwRKhN6?si=US1dT05USgSItcp0ybZovQ
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/emergence-of-the-universe-|-peter-atkins-|-reason-with-science-|-multiverse-|-physics/3ef09511-b6fd-4d44-84ae-59fbb5c974bb
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/ZTQyYzAzMTUtMDg4Ni00NTAyLWE0MjctOWQ3ZDM5NDQ1NGFi?sa=X&ved=0CAUQkfYCahcKEwjo-4GQ-5X8AhUAAAAAHQAAAAAQLA
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/i d1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:00:56 What is emergence?
00:02:30 what is the relation between emergence, Complexity and self-organisation?
00:12:42 How the universe originated?
00:31:00 understanding nothing and multiverse
00:32:07 How time emerges?
00:34:09 is nothing still evolving?
00:41:32 Evolution of humanity through time
00:51:05 what does it mean to be human?
00:52:48 how do we discover laws of nature?
00:58:32 outlaws and inlaws.
01:01:55 A grand unified theory in science
01:06:08 are fundamental constants fundamental?
01:17:11 predicting chemistry from physics
01:22:05 Increasing importance of predictions
01:26:05 what are the major questions for science of emergence?
01:29:15 can we create 'absolutely nothing' in the lab?
01:30:14 how much can we account for abstract properties?
01:34:30 future work
01:36:42 Thank you
More talks by Peter:
1) origin of the laws of nature (https://youtu.be/p9Zmzcl85Ds)
2) where do the laws of nature come from (https://youtu.be/0_ckzZWDth8)
3) why emergence is significant (https://youtu.be/rAeEozekhu4)
Music by: Ahmed Hassan ( )
#reasonwithscience #physics #multiverse

Nov 13, 2022 • 1h 28min
Understanding metabolism and aging | Charles Brenner | Reason with Science | NAD system | Anti-aging
This episode is with Charles Brenner. He is the Alfred E Mann Family Foundation Chair in the department of Diabetes and Cancer Metabolism. His research focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress.
Here we talk about what is metabolism?, NAD system, factors affecting NAD system, ageing, anti-ageing research and how NAD system can be used in health?
Guest info:
Website: https://www.brennerlab.net/
Twitter: https://twitter.com/CharlesMBrenner?s=20&t=sP8HvddsdScE8qzeQN_t3Q
Google scholar: https://scholar.google.com/citations?user=XgEjtucAAAAJ&hl=en
Episode links:
Website: https://www.reasonwithscience.com/home/understanding-metabolism-and-aging-with-charles-brenner
Youtube: https://youtu.be/DHh_E3BbtmI
Spotify: https://open.spotify.com/episode/4q1tqsDiIuwi3jNtdZP2UM?si=QB1KgNMxQpu5dJvlNGLqWQ
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/understanding-metabolism-and-aging-|-charles-brenner-|-reason-with-science-|-nad-system-|-anti-aging/8ca959ec-8bbe-466b-a4e5-d2399d40a452
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/YmUxZmQyZDEtMjI1ZC00N2FlLWJjMjAtNjVmZDZkZDRiYzc1?sa=X&ved=0CAUQkfYCahcKEwiou6WW76v7AhUAAAAAHQAAAAAQLA
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:00:51 What is metabolism?
00:01:40 Metabolism at cellular level
00:02:44 Different metabolic processes
00:04:50 NAD (Nicotinamide adenine diamide) system
00:08:20 Food to NAD system
00:13:09 Evolutionary history of NAD system
00:15:44 Molecular description of NAD system
00:20:51 Synthesis of NAD
00:23:21 What is metabolic stress?
00:28:23 Consequences of metabolic stress on NAD system
00:29:45 Conditions caused by NAD deficiency
00:34:23 Impact of food on metabolic stress
00:35:51 Different types of foods and NAD levels
00:40:01 NAD levels and circadian rythem
00:40:50 Genetic predisposition to NAD levels
00:42:40 Are there population wide changes in NAD systems?
00:47:25 Importance of NAD levels in the blood and how much of these can enter in the cell?
00:50:08 Are there modified NMN compounds which can enter in the cell?
00:52:01 NAD system and aging
01:02:25 Objection against 'Sirtuins as drivers of aging'
01:04:29 How do we understand aging?
01:08:25 Biochemical explanation of aging
01:12:20 What kind of biomarkers can help is in studying aging?
01:15:33 Charles' work on NAD system
01:17:05 What sort of system can help us study aging?
01:23:37 Lifestyle and NAD system
01:26:07 NR (Nicotinamide Ribose) as supplements
01:27:19 Thank you!
#reasonwithscience #health #aging

Oct 30, 2022 • 2h 19min
How multicellularity evolves? with William Ratcliff
This episode is with William Ratcliff. He is an Associate Professor at the School of Biological Science at Georgia Tech. Will studies the physics that constrains multicellular structures and examines the minute changes in certain yeast cells that allows them to become multicellular.
Here we talk about origin of life, emergence of complexity, eukaryogenesis, how cells become multicellular? and major questions regarding how multicellularity evolves.
Guest info:
Website: https://ratclifflab.biosci.gatech.edu/
Twitter: https://twitter.com/wc_ratcliff?s=20&t=V9HDIs-TNdMJazo02F8v5Q
Google scholar: https://scholar.google.com/citations?user=wdVRIS0AAAAJ&hl=en
Episode links:
Website: https://www.reasonwithscience.com/home/how-multicellularity-evolves-with-william-ratcliff
Youtube: https://youtu.be/HOrNrg2H5Ok
Spotify: https://open.spotify.com/episode/0xWzhzWozsnIppGpcN1fNx?si=iMvD48OVSPqxhZTfnxv4CQ
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/how-multicellularity-evolves-with-william-ratcliff/20ca73cb-7550-451a-9dae-84e1c415ebed
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/MmIyMGYzZTYtMWY3My00M2UxLTk1YzgtNTQ0MDZlZGJmNmQ5?sa=X&ved=0CAUQkfYCahcKEwio98jQh4n7AhUAAAAAHQAAAAAQLA
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:00:50 Origin of life
00:09:02 Protocells and Last Universal Common Ancestor (LUCA)
00:11:58 Origin of LUCA
00:14:47 Evolution of life from LUCA
00:20:35 Prokaryotes and Eukaryotes
00:27:44 Semantics of colonies, communities and multicellularity
00:38:25 Kin selection and Group selection debate
00:43:12 Reductionism in science
00:49:32 Strong emergence
00:55:49 Snowflake yeasts
01:11:20 Multicellularity in bacteria
01:14:10 Reproduction in yeasts
01:21:11 Growth regulation in snowflake yeasts
01:27:47 Reproduction of snowflake yeasts
01:34:44 Evolutionary game theory
01:38:34 Michael Levin's work on Xenobots 01:41:56 Darwinian evolution is crucial for multicellular systems to evolve
01:47:01 How cellular functions are regulated in multicellular systems?
01:54:52 Nicole King's work on Choanoflagellates 01:57:19 Polarity in multicellular systems
01:59:32 Syncytia (Multinuclear) cells
02:04:22 Snowflake system and major questions about multicellularity 02:15:09 Reverting multicellularity
02:18:09 Thank you!

Oct 22, 2022 • 1h 22min
Quantum physics for babies with Chris Ferrie
This episode is with Chris Ferrie. He is an associate Professor at the University of Technology Sydney and Centre for Quantum Software and Information. His research focuses on quantum information science. Chris also writes children's books and some selected titles include Quantum Physics for Babies, 8 Little Planets and Pandemics for Babies.
In this conversation we talk about beginning of quantum physics, Double slit experiment, matter, understanding reality, quantum entanglement and quantum computing.
Guest info:
Website: https://www.csferrie.com/
Twitter: https://twitter.com/csferrie
Amazon: https://www.amazon.com/Chris-Ferrie/e/B00IZILZR6/ref=aufs_dp_fta_dsk
Youtube: https://www.youtube.com/csferrie
Episode links:
Website: https://www.reasonwithscience.com/home/quantum-physics-for-babies-with-chris-ferrie
Youtube: https://youtu.be/fn1W6Ml_8yY Spotify: https://open.spotify.com/episode/0R2jkglSrfguE347uF4oxk
Apple podcast: https://podcastsconnect.apple.com/my-podcasts/show/reason-with-science/407cd478-4271-4319-8318-fc378d4e7ccb/episode/quantum-physics-for-babies-with-chris-ferrie/100f0595-9def-45e2-bc95-910415a5a077
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw/episode/NDRhZWI0YWEtYWY3OC00ZTAzLThhY2QtYTQyNzhlZDM1Yzk4?sa=X&ved=0CAUQkfYCahcKEwiItfPahvP6AhUAAAAAHQAAAAAQLA
Follow Reason with Science:
Website: https://www.reasonwithscience.com/
Youtube: https://www.youtube.com/channel/reasonwithscience
Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh
Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894
Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw
Timestamps:
00:00:00 Introduction
00:00:55 Do we understand quantum physics?
00:03:50 Double slit experiment
00:08:43 Max Planck and Einstein's work
00:09:58 Early development of quantum theory
00:12:05 'Quantum' in quantum physics
00:12:41 Heisenberg's principle
00:18:56 Schrodinger's equation
00:20:10 Quantum superposition and quantum entanglement
00:22:53 How to understand quantum entanglement?
00:27:26 Measurement
00:30:13 What is matter and nature of reality?
00:34:22 Reductionism
00:36:07 Emergence and theory of everything
00:39:49 Science of chaos/luck/chance 00:42:11 Understanding chaos
00:43:54 Quantum information
00:50:07 Quantum information and consciousness
00:51:31 Work of Bernardo Kastrup and Donald Hoffman
00:54:54 (Eugene) Wigner's friend
00:59:44 Decoherence in quantum physics
01:02:31 Quantum computers
01:07:09 How big are quantum computers?
01:10:10 Problem with quantum computers
01:11:20 2022 Nobel prize in physics
01:15:04 Quantum systems in action
01:18:06 Writing science books for babies
01:21:08 Thank you!
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